Literature DB >> 28050890

Nanoengineered strategies for siRNA delivery: from target assessment to cancer therapeutic efficacy.

Dinesh Kumar Mishra1, Neelam Balekar2, Pradyumna Kumar Mishra3.   

Abstract

The promise of RNA interference (RNAi) technology in cancer therapeutics aims to deliver small interfering RNA (siRNA) for silencing of gene expression in cell type-specific pathway. However, the challenge for the delivery of stable siRNA is hindered by an immune-hostile tumor microenvironment and physiological barriers of the circulatory system. Therefore, the development and validation of safe, stable, and efficient nanoengineered delivery systems are highly essential for effective delivery of siRNA into cancer cells. This review focuses on gene-silencing mechanisms, challenges to siRNA delivery, design and delivery of nanocarrier systems, ongoing clinical trials, and translational prospects for siRNA-mediated cancer therapeutics.

Entities:  

Keywords:  Drug delivery; Nanomedicine; Oncotherapy; RNA interference; Translational research

Mesh：

Substances：

Year:  2017        PMID： 28050890     DOI： 10.1007/s13346-016-0352-5

Source DB:  PubMed          Journal:  Drug Deliv Transl Res        ISSN： 2190-393X            Impact factor:   4.617


  108 in total

Review 1.  Polycation gene delivery systems: escape from endosomes to cytosol.

Authors:  Yong Woo Cho; Jong-Duk Kim; Kinam Park
Journal:  J Pharm Pharmacol       Date:  2003-06       Impact factor: 3.765

Review 2.  Delivery of siRNA therapeutics: barriers and carriers.

Authors:  Jie Wang; Ze Lu; M Guillaume Wientjes; Jessie L-S Au
Journal:  AAPS J       Date:  2010-06-11       Impact factor: 4.009

Review 3.  Nanoengineered strategies to optimize dendritic cells for gastrointestinal tumor immunotherapy: from biology to translational medicine.

Authors:  Arpit Bhargava; Neha Bunkar; Naveen Kumar Khare; Dinesh Mishra; Pradyumna Kumar Mishra
Journal:  Nanomedicine (Lond)       Date:  2014-07       Impact factor: 5.307

4.  Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs.

Authors:  Jürgen Soutschek; Akin Akinc; Birgit Bramlage; Klaus Charisse; Rainer Constien; Mary Donoghue; Sayda Elbashir; Anke Geick; Philipp Hadwiger; Jens Harborth; Matthias John; Venkitasamy Kesavan; Gary Lavine; Rajendra K Pandey; Timothy Racie; Kallanthottathil G Rajeev; Ingo Röhl; Ivanka Toudjarska; Gang Wang; Silvio Wuschko; David Bumcrot; Victor Koteliansky; Stefan Limmer; Muthiah Manoharan; Hans-Peter Vornlocher
Journal:  Nature       Date:  2004-11-11       Impact factor: 49.962

5.  Quantum-dot based nanoparticles for targeted silencing of HER2/neu gene via RNA interference.

Authors:  Wee Beng Tan; Shan Jiang; Yong Zhang
Journal:  Biomaterials       Date:  2006-12-11       Impact factor: 12.479

Review 6.  Drug delivery and transport to solid tumors.

Authors:  Seong Hoon Jang; M Guillaume Wientjes; Dan Lu; Jessie L S Au
Journal:  Pharm Res       Date:  2003-09       Impact factor: 4.200

7.  Analysis of gene function in somatic mammalian cells using small interfering RNAs.

Authors:  Sayda M Elbashir; Jens Harborth; Klaus Weber; Thomas Tuschl
Journal:  Methods       Date:  2002-02       Impact factor: 3.608

Review 8.  Targeting multidrug resistance in cancer.

Authors:  Gergely Szakács; Jill K Paterson; Joseph A Ludwig; Catherine Booth-Genthe; Michael M Gottesman
Journal:  Nat Rev Drug Discov       Date:  2006-03       Impact factor: 84.694

Review 9.  Nanoparticle-based delivery of small interfering RNA: challenges for cancer therapy.

Authors:  Evelina Miele; Gian Paolo Spinelli; Ermanno Miele; Enzo Di Fabrizio; Elisabetta Ferretti; Silverio Tomao; Alberto Gulino
Journal:  Int J Nanomedicine       Date:  2012-07-20

Review 10.  Recent developments in nanoparticle-based siRNA delivery for cancer therapy.

Authors:  Jong-Min Lee; Tae-Jong Yoon; Young-Seok Cho
Journal:  Biomed Res Int       Date:  2013-06-17       Impact factor: 3.411
View more
  11 in total

1.  [Construction and verification of anti-MM scFv-tP fusion protein expression vector].

Authors:  Hao Wang; Yi-Fei Yang; Wei Wang; Bing Guan; Meng Xun; Hai Zhang; Zi-Ling Wang; Yong Zhao
Journal:  Nan Fang Yi Ke Da Xue Xue Bao       Date:  2017-09-20

2.  Steering the Clinical Translation of Delivery Systems for Drugs and Health Products.

Authors:  Rosario Pignatello; Pietro Matricardi
Journal:  Pharmaceutics       Date:  2020-04-13       Impact factor: 6.321

3.  Trimethyl-Chitosan Coated Gold Nanoparticles Enhance Delivery, Cellular Uptake and Gene Silencing Effect of EGFR-siRNA in Breast Cancer Cells.

Authors:  Leila Baghani; Niloofar Noroozi Heris; Fatemeh Khonsari; Sajad Dinarvand; Meshkat Dinarvand; Fatemeh Atyabi
Journal:  Front Mol Biosci       Date:  2022-04-20

4.  Clinical values of Ku80 upregulation in superficial esophageal squamous cell carcinoma.

Authors:  Shuai Wang; Junjie Xi; Zongwu Lin; Jiatao Hao; Can Yao; Cheng Zhan; Wei Jiang; Yu Shi; Qun Wang
Journal:  Cancer Med       Date:  2018-03-13       Impact factor: 4.452

5.  Overcoming multidrug resistance through inhalable siRNA nanoparticles-decorated porous microparticles based on supercritical fluid technology.

Authors:  Pei-Yao Xu; Ranjith Kumar Kankala; Yu-Jing Pan; Hui Yuan; Shi-Bin Wang; Ai-Zheng Chen
Journal:  Int J Nanomedicine       Date:  2018-08-15

6.  Downregulation of long non-coding RNA LINP1 inhibits the malignant progression of esophageal squamous cell carcinoma.

Authors:  Tao Lu; Ke Ma; Cheng Zhan; Xiaodong Yang; Yu Shi; Wei Jiang; Hao Wang; Shuai Wang; Qun Wang; Lijie Tan
Journal:  Ann Transl Med       Date:  2020-06

Review 7.  Current Trends and Challenges in the Clinical Translation of Nanoparticulate Nanomedicines: Pathways for Translational Development and Commercialization.

Authors:  Susan Hua; Maria B C de Matos; Josbert M Metselaar; Gert Storm
Journal:  Front Pharmacol       Date:  2018-07-17       Impact factor: 5.810

Review 8.  Polymers in the Delivery of siRNA for the Treatment of Virus Infections.

Authors:  Nicholas Reynolds; Megan Dearnley; Tracey M Hinton
Journal:  Top Curr Chem (Cham)       Date:  2017-03-21

Review 9.  Emerging trends in the nanomedicine applications of functionalized magnetic nanoparticles as novel therapies for acute and chronic diseases.

Authors:  Sabyasachi Dash; Tuhin Das; Paritosh Patel; Pritam Kumar Panda; Mrutyunjay Suar; Suresh K Verma
Journal:  J Nanobiotechnology       Date:  2022-08-31       Impact factor: 9.429

Review 10.  Aptamers as Delivery Agents of siRNA and Chimeric Formulations for the Treatment of Cancer.

Authors:  Ana Paula Dinis Ano Bom; Patrícia Cristina da Costa Neves; Carlos Eduardo Bonacossa de Almeida; Dilson Silva; Sotiris Missailidis
Journal:  Pharmaceutics       Date:  2019-12-16       Impact factor: 6.321
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.