Literature DB >> 28042179

Tritylation of Alcohols under Mild Conditions without Using Silver Salts.

Shahien Shahsavari1, Jinsen Chen1, Travis Wigstrom1, James Gooding1, Alexander Gauronskas1, Shiyue Fang1.   

Abstract

Secondary alcohols were conveniently tritylated under mild conditions within a short running time with tritylium trifluoroacetate generated in situ from trityl alcohols and trifluoroacetic anhydride. No expensive silver salts were needed for the reactions. Four secondary alcohols were tritylated with both mono- and dimethoxy trityl alcohols giving good to excellent isolated yields. The reaction was also tested on four nucleoside derivatives that have primary alcohols. Satisfactory results were also obtained.

Entities:  

Keywords:  Alcohols; Nucleosides; Protecting groups; Trifluoroacetic anhydride; Tritylation

Year:  2016        PMID： 28042179      PMCID： PMC5193390          DOI： 10.1016/j.tetlet.2016.07.062

Source DB:  PubMed          Journal:  Tetrahedron Lett        ISSN： 0040-4039            Impact factor:   2.415


  18 in total

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