Literature DB >> 27992880

A fluorescent probe for cysteine depalmitoylation reveals dynamic APT signaling.

Rahul S Kathayat1, Pablo D Elvira1, Bryan C Dickinson1.   

Abstract

Hundreds of human proteins are modified by reversible palmitoylation of cysteine residues (S-palmitoylation), but the regulation of depalmitoylation is poorly understood. Here, we develop 'depalmitoylation probes' (DPPs), small-molecule fluorophores, to monitor the endogenous activity levels of 'erasers' of S-palmitoylation, acylprotein thioesterases (APTs). Live-cell analysis with DPPs reveals rapid growth-factor-mediated inhibition of the depalmitoylation activity of APTs, exposing a novel regulatory mechanism of dynamic lipid signaling.

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Year:  2016        PMID： 27992880      PMCID： PMC5247352          DOI： 10.1038/nchembio.2262

Source DB:  PubMed          Journal:  Nat Chem Biol        ISSN： 1552-4450            Impact factor:   15.040


  25 in total

1.  Synaptic strength regulated by palmitate cycling on PSD-95.

Authors:  Alaa El-Din El-Husseini; Eric Schnell; Srikanth Dakoji; Neal Sweeney; Qiang Zhou; Oliver Prange; Catherine Gauthier-Campbell; Andrea Aguilera-Moreno; Roger A Nicoll; David S Bredt
Journal:  Cell       Date:  2002-03-22       Impact factor: 41.582

2.  Chemical-biological exploration of the limits of the Ras de- and repalmitoylating machinery.

Authors:  Kristina Görmer; Marco Bürger; John A W Kruijtzer; Ingrid Vetter; Nachiket Vartak; Lucas Brunsveld; Philippe I H Bastiaens; Rob M J Liskamp; Gemma Triola; Herbert Waldmann
Journal:  Chembiochem       Date:  2012-04-05       Impact factor: 3.164

3.  Acyl protein thioesterase inhibitors as probes of dynamic S-palmitoylation.

Authors:  Dahvid Davda; Brent R Martin
Journal:  Medchemcomm       Date:  2014-03       Impact factor: 3.597

4.  N-terminal palmitoylation of PSD-95 regulates association with cell membranes and interaction with K+ channel Kv1.4.

Authors:  J R Topinka; D S Bredt
Journal:  Neuron       Date:  1998-01       Impact factor: 17.173

5.  Identification of acyl protein thioesterases 1 and 2 as the cellular targets of the Ras-signaling modulators palmostatin B and M.

Authors:  Marion Rusch; Tobias J Zimmermann; Marco Bürger; Frank J Dekker; Kristina Görmer; Gemma Triola; Andreas Brockmeyer; Petra Janning; Thomas Böttcher; Stephan A Sieber; Ingrid R Vetter; Christian Hedberg; Herbert Waldmann
Journal:  Angew Chem Int Ed Engl       Date:  2011-09-09       Impact factor: 15.336

6.  Small-molecule inhibition of APT1 affects Ras localization and signaling.

Authors:  Frank J Dekker; Oliver Rocks; Nachiket Vartak; Sascha Menninger; Christian Hedberg; Rengarajan Balamurugan; Stefan Wetzel; Steffen Renner; Marc Gerauer; Beate Schölermann; Marion Rusch; John W Kramer; Daniel Rauh; Geoffrey W Coates; Luc Brunsveld; Philippe I H Bastiaens; Herbert Waldmann
Journal:  Nat Chem Biol       Date:  2010-04-25       Impact factor: 15.040

Review 7.  Proteomic analysis of fatty-acylated proteins.

Authors:  Tao Peng; Emmanuelle Thinon; Howard C Hang
Journal:  Curr Opin Chem Biol       Date:  2015-12-02       Impact factor: 8.822

Review 8.  Profiling and inhibiting reversible palmitoylation.

Authors:  Jeannie L Hernandez; Jaimeen D Majmudar; Brent R Martin
Journal:  Curr Opin Chem Biol       Date:  2013-01-01       Impact factor: 8.822

Review 9.  Protein lysine acylation and cysteine succination by intermediates of energy metabolism.

Authors:  Hening Lin; Xiaoyang Su; Bin He
Journal:  ACS Chem Biol       Date:  2012-05-16       Impact factor: 5.100

10.  Autopalmitoylation of TEAD proteins regulates transcriptional output of the Hippo pathway.

Authors:  PuiYee Chan; Xiao Han; Baohui Zheng; Michael DeRan; Jianzhong Yu; Gopala K Jarugumilli; Hua Deng; Duojia Pan; Xuelian Luo; Xu Wu
Journal:  Nat Chem Biol       Date:  2016-02-22       Impact factor: 15.040
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  24 in total

1.  Synthetic Fluorogenic Peptides Reveal Dynamic Substrate Specificity of Depalmitoylases.

Authors:  Neri Amara; Ian T Foe; Ouma Onguka; Megan Garland; Matthew Bogyo
Journal:  Cell Chem Biol       Date:  2018-11-01       Impact factor: 8.116

2.  Temporal Profiling Establishes a Dynamic S-Palmitoylation Cycle.

Authors:  Sang Joon Won; Brent R Martin
Journal:  ACS Chem Biol       Date:  2018-05-23       Impact factor: 5.100

3.  Measuring S-Depalmitoylation Activity In Vitro and In Live Cells with Fluorescent Probes.

Authors:  Rahul S Kathayat; Bryan C Dickinson
Journal:  Methods Mol Biol       Date:  2019

4.  Imaging Ca2+ with a Fluorescent Rhodol.

Authors:  Alisha A Contractor; Evan W Miller
Journal:  Biochemistry       Date:  2017-11-28       Impact factor: 3.162

5.  Activity-Based Sensing of S-Depalmitoylases: Chemical Technologies and Biological Discovery.

Authors:  Saara-Anne Azizi; Rahul S Kathayat; Bryan C Dickinson
Journal:  Acc Chem Res       Date:  2019-10-02       Impact factor: 22.384

Review 6.  Activity-Based Sensing: A Synthetic Methods Approach for Selective Molecular Imaging and Beyond.

Authors:  Kevin J Bruemmer; Steven W M Crossley; Christopher J Chang
Journal:  Angew Chem Int Ed Engl       Date:  2020-04-23       Impact factor: 15.336

Review 7.  Protein depalmitoylases.

Authors:  Sang Joon Won; Melanie Cheung See Kit; Brent R Martin
Journal:  Crit Rev Biochem Mol Biol       Date:  2017-12-14       Impact factor: 8.250

8.  Cell contact and Nf2/Merlin-dependent regulation of TEAD palmitoylation and activity.

Authors:  Nam-Gyun Kim; Barry M Gumbiner
Journal:  Proc Natl Acad Sci U S A       Date:  2019-05-01       Impact factor: 11.205

Review 9.  Protein Lipidation in Cell Signaling and Diseases: Function, Regulation, and Therapeutic Opportunities.

Authors:  Baoen Chen; Yang Sun; Jixiao Niu; Gopala K Jarugumilli; Xu Wu
Journal:  Cell Chem Biol       Date:  2018-05-31       Impact factor: 8.116

10.  A Fluorescent Probe with Improved Water Solubility Permits the Analysis of Protein S-Depalmitoylation Activity in Live Cells.

Authors:  Tian Qiu; Rahul S Kathayat; Yang Cao; Michael W Beck; Bryan C Dickinson
Journal:  Biochemistry       Date:  2017-10-18       Impact factor: 3.162
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