Literature DB >> 27931093

Drug-Loaded Polymeric Spherical Nucleic Acids: Enhancing Colloidal Stability and Cellular Uptake of Polymeric Nanoparticles through DNA Surface-Functionalization.

Resham J Banga1, Sai Archana Krovi1, Suguna P Narayan1, Anthony J Sprangers1, Guoliang Liu1, Chad A Mirkin1, SonBinh T Nguyen1.   

Abstract

Small-sized (∼65 nm) doxorubicin (Dox)-loaded polymeric nanoparticles (PNPs) were modified with oligonucleotides to form colloidally stable Dox-loaded polymeric spherical nucleic acid (Dox-PSNA) nanostructures in biological media. The nucleic acid shell facilitates the cellular uptake of Dox-PSNA, which results in in vitro cytotoxicity against SKOV3 cancer cells.

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Year:  2017        PMID： 27931093      PMCID： PMC5550325          DOI： 10.1021/acs.biomac.6b01563

Source DB:  PubMed          Journal:  Biomacromolecules        ISSN： 1525-7797            Impact factor:   6.988


  39 in total

Review 1.  Intracellular targeting of polymer-bound drugs for cancer chemotherapy.

Authors:  Aparna Nori; Jindrich Kopecek
Journal:  Adv Drug Deliv Rev       Date:  2004-12-24       Impact factor: 15.470

2.  Multifunctional polymeric nanoparticles from diverse bioactive agents.

Authors:  Paul A Bertin; Julianne M Gibbs; Clifton Kwang-Fu Shen; C Shad Thaxton; William A Russin; Chad A Mirkin; Sonbinh T Nguyen
Journal:  J Am Chem Soc       Date:  2006-04-05       Impact factor: 15.419

3.  DNA-mediated engineering of multicomponent enzyme crystals.

Authors:  Jeffrey D Brodin; Evelyn Auyeung; Chad A Mirkin
Journal:  Proc Natl Acad Sci U S A       Date:  2015-03-23       Impact factor: 11.205

4.  The Sequence-Specific Cellular Uptake of Spherical Nucleic Acid Nanoparticle Conjugates.

Authors:  Suguna P Narayan; Chung Hang J Choi; Liangliang Hao; Colin M Calabrese; Evelyn Auyeung; Chuan Zhang; Olga J G M Goor; Chad A Mirkin
Journal:  Small       Date:  2015-06-11       Impact factor: 13.281

Review 5.  Silver nanoparticle-oligonucleotide conjugates based on DNA with triple cyclic disulfide moieties.

Authors:  Jae-Seung Lee; Abigail K R Lytton-Jean; Sarah J Hurst; Chad A Mirkin
Journal:  Nano Lett       Date:  2007-06-16       Impact factor: 11.189

6.  Oligonucleotide loading determines cellular uptake of DNA-modified gold nanoparticles.

Authors:  David A Giljohann; Dwight S Seferos; Pinal C Patel; Jill E Millstone; Nathaniel L Rosi; Chad A Mirkin
Journal:  Nano Lett       Date:  2007-11-13       Impact factor: 11.189

7.  Polyvalent oligonucleotide gold nanoparticle conjugates as delivery vehicles for platinum(IV) warheads.

Authors:  Shanta Dhar; Weston L Daniel; David A Giljohann; Chad A Mirkin; Stephen J Lippard
Journal:  J Am Chem Soc       Date:  2009-10-21       Impact factor: 15.419

8.  Synthesis and In vitro activity of ROMP-based polymer nanoparticles.

Authors:  Deedee Smith; Sandra H Clark; Paul A Bertin; Bernard L Mirkin; Sonbinh T Nguyen
Journal:  J Mater Chem       Date:  2009-04-21

9.  "Clickable" polymer-caged nanobins as a modular drug delivery platform.

Authors:  Sang-Min Lee; Haimei Chen; Thomas V O'Halloran; SonBinh T Nguyen
Journal:  J Am Chem Soc       Date:  2009-07-08       Impact factor: 15.419

10.  Intracellular mRNA regulation with self-assembled locked nucleic acid polymer nanoparticles.

Authors:  Anthony M Rush; David A Nelles; Angela P Blum; Sarah A Barnhill; Erick T Tatro; Gene W Yeo; Nathan C Gianneschi
Journal:  J Am Chem Soc       Date:  2014-05-14       Impact factor: 15.419
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  10 in total

Review 1.  Design strategies for physical-stimuli-responsive programmable nanotherapeutics.

Authors:  Fitsum Feleke Sahle; Muhammad Gulfam; Tao L Lowe
Journal:  Drug Discov Today       Date:  2018-04-10       Impact factor: 7.851

2.  Impact of Sequence Specificity of Spherical Nucleic Acids on Macrophage Activation in Vitro and in Vivo.

Authors:  Chenxia M Guan; Alyssa B Chinen; Jennifer R Ferrer; Caroline H Ko; Chad A Mirkin
Journal:  Mol Pharm       Date:  2019-09-19       Impact factor: 4.939

3.  Exploring the Structural Diversity of DNA Bottlebrush Polymers Using an Oligonucleotide Macromonomer Approach.

Authors:  Hao Lu; Jiansong Cai; Yang Fang; Mengqi Ren; Xuyu Tan; Fei Jia; Dali Wang; Ke Zhang
Journal:  Macromolecules       Date:  2022-03-01       Impact factor: 6.057

4.  Expanding the materials space of DNA via organic-phase ring-opening metathesis polymerization.

Authors:  Xuyu Tan; Hao Lu; Yehui Sun; Xiaoying Chen; Dali Wang; Fei Jia; Ke Zhang
Journal:  Chem       Date:  2019-04-22       Impact factor: 22.804

5.  Design strategies for programmable oligonucleotide nanotherapeutics.

Authors:  Fitsum Feleke Sahle; Tao L Lowe
Journal:  Drug Discov Today       Date:  2019-09-13       Impact factor: 7.851

Review 6.  Functional DNA-Polymer Conjugates.

Authors:  Colette J Whitfield; Meizhou Zhang; Pia Winterwerber; Yuzhou Wu; David Y W Ng; Tanja Weil
Journal:  Chem Rev       Date:  2021-03-19       Impact factor: 60.622

7.  Block copolymer conjugated Au-coated Fe3O4 nanoparticles as vectors for enhancing colloidal stability and cellular uptake.

Authors:  Junbo Li; Sheng Zou; Jiayu Gao; Ju Liang; Huiyun Zhou; Lijuan Liang; Wenlan Wu
Journal:  J Nanobiotechnology       Date:  2017-07-25       Impact factor: 10.435

8.  Spherical nucleic acids: Organized nucleotide aggregates as versatile nanomedicine.

Authors:  Yangmeihui Song; Wenyu Song; Xiaoli Lan; Weibo Cai; Dawei Jiang
Journal:  Aggregate (Hoboken)       Date:  2021-09-14

9.  Nucleic acid-based supramolecular structures: vesicular spherical nucleic acids from a non-phospholipid nucleolipid.

Authors:  Erik Dimitrov; Natalia Toncheva-Moncheva; Pavel Bakardzhiev; Aleksander Forys; Jordan Doumanov; Kirilka Mladenova; Svetla Petrova; Barbara Trzebicka; Stanislav Rangelov
Journal:  Nanoscale Adv       Date:  2022-08-09

Review 10.  Chemistries and applications of DNA-natural product conjugate.

Authors:  Yuanyuan Chen; Wenting Li; Hang Xing
Journal:  Front Chem       Date:  2022-09-06       Impact factor: 5.545
  10 in total

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