Alexandru Hanganu1, Marie-Andrée Bruneau2, Clotilde Degroot3, Christophe Bedetti4, Béatriz Mejia-Constain5, Anne-Louise Lafontaine6, Sylvain Chouinard7, Oury Monchi8. 1. Department of Clinical Neurosciences and Department of Radiology, University of Calgary, Calgary, AB, Canada; Hotchkiss Brain Institute, Calgary, AB, Canada; Centre de Recherche, Institut Universitaire de Gériatrie de Montréal, Montréal, QC, Canada. Electronic address: alexandru.hanganu@ucalgary.ca. 2. Centre de Recherche, Institut Universitaire de Gériatrie de Montréal, Montréal, QC, Canada. Electronic address: ma.bruneau@videotron.ca. 3. Centre de Recherche, Institut Universitaire de Gériatrie de Montréal, Montréal, QC, Canada; Montreal Neurological Institute and Hospital, McGill University, Montréal, QC, Canada. Electronic address: clotilde.degroot@mcgill.ca. 4. Centre d'Études Avancées en Médecine du Sommeil, Hôpital du Sacré Cœur de Montréal, Montréal, QC, Canada. Electronic address: christophe.bedetti@criugm.qc.ca. 5. Centre de Recherche, Institut Universitaire de Gériatrie de Montréal, Montréal, QC, Canada. Electronic address: beatriz.mejia-constain@umontreal.ca. 6. Montreal Neurological Institute and Hospital, McGill University, Montréal, QC, Canada; Movement Disorders Unit, McGill University Health Centre, Montréal, QC, Canada. Electronic address: anne-louise.lafontaine@mcgill.ca. 7. Unité des troubles du mouvement André Barbeau, Centre Hospitalier de l'Université de Montréal, Montréal, QC, Canada. Electronic address: sylvainchouinard@me.com. 8. Department of Clinical Neurosciences and Department of Radiology, University of Calgary, Calgary, AB, Canada; Hotchkiss Brain Institute, Calgary, AB, Canada; Centre de Recherche, Institut Universitaire de Gériatrie de Montréal, Montréal, QC, Canada; Montreal Neurological Institute and Hospital, McGill University, Montréal, QC, Canada. Electronic address: oury.monchi@ucalgary.ca.
Abstract
INTRODUCTION: Depressive symptoms are very common in patients with Parkinson's disease (PD) and have a significant impact on the quality of life. METHODS: The present study analyzed the correlations between over-time changes in depressive symptoms and gray matter parameters of cortical thickness and subcortical volumes in non-demented PD patients. RESULTS: A significant correlation was observed, between increased scores for depression over time and lower cortical thickness over time in the right temporo-parietal junction, right occipital medial region, right dorsolateral prefrontal cortex, right posterior cingulate region, left middle temporal as well as left supplementary motor area. Furthermore, the presence of depressive symptoms at baseline predicted increased cortical thinning over time in the left middle temporal, left anterior cingulate, right posterior cingulate and right parahippocampal cortices. Finally, a statistically significant negative correlation has been revealed between the thalamus' volume changes over time and the change in depressive symptoms scores. All other analyzed subcortical structures didn't reveal any significant correlations. CONCLUSION: These results suggest that depressive symptoms in PD patients are associated with gray matter cortical thinning and thalamus volume shrinkage over time and higher scores of depressive symptoms at baseline correlate with a higher rate of cortical thinning longitudinally. The present study highlights the importance of addressing depressive symptoms in PD patients early in the disease.
INTRODUCTION:Depressive symptoms are very common in patients with Parkinson's disease (PD) and have a significant impact on the quality of life. METHODS: The present study analyzed the correlations between over-time changes in depressive symptoms and gray matter parameters of cortical thickness and subcortical volumes in non-demented PDpatients. RESULTS: A significant correlation was observed, between increased scores for depression over time and lower cortical thickness over time in the right temporo-parietal junction, right occipital medial region, right dorsolateral prefrontal cortex, right posterior cingulate region, left middle temporal as well as left supplementary motor area. Furthermore, the presence of depressive symptoms at baseline predicted increased cortical thinning over time in the left middle temporal, left anterior cingulate, right posterior cingulate and right parahippocampal cortices. Finally, a statistically significant negative correlation has been revealed between the thalamus' volume changes over time and the change in depressive symptoms scores. All other analyzed subcortical structures didn't reveal any significant correlations. CONCLUSION: These results suggest that depressive symptoms in PDpatients are associated with gray matter cortical thinning and thalamus volume shrinkage over time and higher scores of depressive symptoms at baseline correlate with a higher rate of cortical thinning longitudinally. The present study highlights the importance of addressing depressive symptoms in PDpatients early in the disease.
Authors: Ziv Gan-Or; Trisha Rao; Etienne Leveille; Clotilde Degroot; Sylvain Chouinard; Francesca Cicchetti; Alain Dagher; Samir Das; Alex Desautels; Janelle Drouin-Ouellet; Thomas Durcan; Jean-François Gagnon; Angela Genge; Jason Karamchandani; Anne-Louise Lafontaine; Sonia Lai Wing Sun; Mélanie Langlois; Martin Levesque; Calvin Melmed; Michel Panisset; Martin Parent; Jean-Baptiste Poline; Ronald B Postuma; Emmanuelle Pourcher; Guy A Rouleau; Madeleine Sharp; Oury Monchi; Nicolas Dupré; Edward A Fon Journal: J Parkinsons Dis Date: 2020 Impact factor: 5.568