Eun Jin Yoon1, Zahinoor Ismail1, Alexandru Hanganu1, Mekale Kibreab1, Tracy Hammer1, Jenelle Cheetham1, Iris Kathol1, Justyna R Sarna1, Davide Martino1, Sarah Furtado1, Oury Monchi2. 1. From the Department of Clinical Neurosciences (E.J.Y., Z.I., A.H., M.K., T.H., J.C., I.K., J.R.S., D.M., S.F., O.M.) and Departments of Psychiatry and Community Health Sciences (Z.I.), University of Calgary; Hotchkiss Brain Institute (E.J.Y., Z.I., A.H., M.K., T.H., J.C., I.K., J.R.S., D.M., S.F., O.M.), Cumming School of Medicine, Calgary, Alberta; Centre de Recherche (A.H., O.M.), Institut Universitaire de Gériatrie de Montréal; and Department of Psychology (A.H.), University of Montréal, Québec, Canada. 2. From the Department of Clinical Neurosciences (E.J.Y., Z.I., A.H., M.K., T.H., J.C., I.K., J.R.S., D.M., S.F., O.M.) and Departments of Psychiatry and Community Health Sciences (Z.I.), University of Calgary; Hotchkiss Brain Institute (E.J.Y., Z.I., A.H., M.K., T.H., J.C., I.K., J.R.S., D.M., S.F., O.M.), Cumming School of Medicine, Calgary, Alberta; Centre de Recherche (A.H., O.M.), Institut Universitaire de Gériatrie de Montréal; and Department of Psychology (A.H.), University of Montréal, Québec, Canada. oury.monchi@ucalgary.ca.
Abstract
OBJECTIVE: To evaluate the associations of mild behavioral impairment (MBI) with cognitive deficits and patterns of gray matter changes in Parkinson disease (PD). METHODS: Sixty patients with PD without dementia and 29 healthy controls underwent a cognitive neuropsychological evaluation and structural MRI scan. MBI was evaluated with the MBI Checklist (MBI-C), a rating scale designed to elicit emergent neuropsychiatric symptoms in accordance with MBI criteria. We divided the patients with PD into 2 groups: 1 group with high MBI-C scores (PD-MBI) and the other with low MBI-C scores (PD-noMBI). RESULTS: Among 60 patients with PD, 20 were categorized as having PD-MBI (33.33%). In healthy controls, no participants met the MBI cut-point threshold. The PD-MBI group had significantly lower Montreal Cognitive Assessment and z scores in all 5 domains and the global score compared to healthy controls and those with PD-noMBI. In addition, all cognitive domains except language and global cognition negatively correlated with the MBI-C total score in all patients with PD. For cortical structures, the PD-MBI group revealed middle temporal cortex thinning and decreased volume compared with the PD-noMBI group, and decreased volume in this area negatively correlated with the MBI-C total score. CONCLUSIONS: The impaired cognitive function over all domains and atrophy in the temporal area in the PD-MBI group are in line with posterior cortical circuit deficits in PD, which have been associated with a faster rate of progression to dementia. These initial results suggest that MBI might be an early and important marker for incident cognitive decline and dementia in patients with PD.
OBJECTIVE: To evaluate the associations of mild behavioral impairment (MBI) with cognitive deficits and patterns of gray matter changes in Parkinson disease (PD). METHODS: Sixty patients with PD without dementia and 29 healthy controls underwent a cognitive neuropsychological evaluation and structural MRI scan. MBI was evaluated with the MBI Checklist (MBI-C), a rating scale designed to elicit emergent neuropsychiatric symptoms in accordance with MBI criteria. We divided the patients with PD into 2 groups: 1 group with high MBI-C scores (PD-MBI) and the other with low MBI-C scores (PD-noMBI). RESULTS: Among 60 patients with PD, 20 were categorized as having PD-MBI (33.33%). In healthy controls, no participants met the MBI cut-point threshold. The PD-MBI group had significantly lower Montreal Cognitive Assessment and z scores in all 5 domains and the global score compared to healthy controls and those with PD-noMBI. In addition, all cognitive domains except language and global cognition negatively correlated with the MBI-C total score in all patients with PD. For cortical structures, the PD-MBI group revealed middle temporal cortex thinning and decreased volume compared with the PD-noMBI group, and decreased volume in this area negatively correlated with the MBI-C total score. CONCLUSIONS: The impaired cognitive function over all domains and atrophy in the temporal area in the PD-MBI group are in line with posterior cortical circuit deficits in PD, which have been associated with a faster rate of progression to dementia. These initial results suggest that MBI might be an early and important marker for incident cognitive decline and dementia in patients with PD.
Authors: M E Peters; P B Rosenberg; M Steinberg; M C Norton; K A Welsh-Bohmer; K M Hayden; J Breitner; J T Tschanz; C G Lyketsos Journal: Am J Geriatr Psychiatry Date: 2013-02-06 Impact factor: 4.105
Authors: Zahinoor Ismail; Luis Agüera-Ortiz; Henry Brodaty; Alicja Cieslak; Jeffrey Cummings; Corinne E Fischer; Serge Gauthier; Yonas E Geda; Nathan Herrmann; Jamila Kanji; Krista L Lanctôt; David S Miller; Moyra E Mortby; Chiadi U Onyike; Paul B Rosenberg; Eric E Smith; Gwenn S Smith; David L Sultzer; Constantine Lyketsos Journal: J Alzheimers Dis Date: 2017 Impact factor: 4.472
Authors: Nancy J Donovan; Lauren P Wadsworth; Natacha Lorius; Joseph J Locascio; Dorene M Rentz; Keith A Johnson; Reisa A Sperling; Gad A Marshall Journal: Am J Geriatr Psychiatry Date: 2013-07-24 Impact factor: 4.105
Authors: Zachary A Macchi; Sandhya Seshadri; Roman Ayele; Meredith Bock; Judith Long; Heather Coats; Janis Miyasaki; Steven Z Pantilat; Maya Katz; Elizabeth J Santos; Stefan H Sillau; Hillary D Lum; Benzi M Kluger Journal: Mov Disord Clin Pract Date: 2022-09-07
Authors: Mirnova E Ceïde; Daniel Eguchi; Emmeline I Ayers; David W Lounsbury; Joe Verghese Journal: Int J Environ Res Public Health Date: 2022-06-16 Impact factor: 4.614
Authors: Zahinoor Ismail; Byron Creese; Dag Aarsland; Helen C Kales; Constantine G Lyketsos; Robert A Sweet; Clive Ballard Journal: Nat Rev Neurol Date: 2022-01-04 Impact factor: 44.711
Authors: Maiya R Geddes; Megan E O'Connell; John D Fisk; Serge Gauthier; Richard Camicioli; Zahinoor Ismail Journal: Alzheimers Dement (Amst) Date: 2020-09-22
Authors: Sascha Gill; Meng Wang; Pauline Mouches; Deepthi Rajashekar; Tolulope Sajobi; Frank P MacMaster; Eric E Smith; Nils D Forkert; Zahinoor Ismail Journal: Int J Geriatr Psychiatry Date: 2021-04-09 Impact factor: 3.850
Authors: James P Naude; Sascha Gill; Sophie Hu; Alexander McGirr; Nils D Forkert; Oury Monchi; Peter K Stys; Eric E Smith; Zahinoor Ismail Journal: J Alzheimers Dis Date: 2020 Impact factor: 4.472