John A Shepherd1, Markus J Sommer2, Bo Fan2, Cassidy Powers2, Lynda Stranix-Chibanda3, Amanda Zadzilka4, Michael Basar4, Kathy George4, Cynthia Mukwasi-Kahari3, George Siberry5. 1. Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA. Electronic address: John.Shepherd@ucsf.edu. 2. Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA. 3. College of Health Sciences, University of Zimbabwe, Harare, Zimbabwe. 4. Frontier Science and Technology Research Foundation, Amherst, NY. 5. Maternal and Pediatric Infectious Disease Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD.
Abstract
OBJECTIVE: To evaluate a novel technique designed to reduce the negative impact of motion artifacts in infant dual-energy X-ray absorptiometry (DXA) scans. STUDY DESIGN: Using cross-sectional data from a large multicenter study, we developed and tested advanced methods for infant scan analysis. Newborns (n = 750) received spine and whole-body DXA scans with up to 3 attempts to acquire a motion free scan. Precision of infant DXA was estimated from visits with multiple valid scans. Accuracy of regional reflection, fusion, and omission techniques was estimated by comparing modified scans to unmodified valid scans. The effectiveness of the acquisition and analysis protocol was represented by the reduction in rate of failure to acquire valid results from infant visits. RESULTS: For infant whole-body DXA, arm reflection and all fusion techniques caused no significant changes to bone mineral content, bone mineral density, bone area, total mass, fat mass, lean mass, and percentage fat. Leg reflection and arm/leg dual-reflection caused significant changes to total mass, but the percentage change remained small. For infant spine DXA, fusion and omission caused no significant changes. Advanced analysis techniques reduced the failure rate of whole-body scanning from 20.8% to 9.3% and the failure rate of spine scanning from 8.9% to 2.4%. CONCLUSIONS: Advanced analysis techniques significantly reduced the impact of motion artifacts on infant DXA scans. We suggest this protocol be used in future infant DXA research and clinical practice.
OBJECTIVE: To evaluate a novel technique designed to reduce the negative impact of motion artifacts in infant dual-energy X-ray absorptiometry (DXA) scans. STUDY DESIGN: Using cross-sectional data from a large multicenter study, we developed and tested advanced methods for infant scan analysis. Newborns (n = 750) received spine and whole-body DXA scans with up to 3 attempts to acquire a motion free scan. Precision of infant DXA was estimated from visits with multiple valid scans. Accuracy of regional reflection, fusion, and omission techniques was estimated by comparing modified scans to unmodified valid scans. The effectiveness of the acquisition and analysis protocol was represented by the reduction in rate of failure to acquire valid results from infant visits. RESULTS: For infant whole-body DXA, arm reflection and all fusion techniques caused no significant changes to bone mineral content, bone mineral density, bone area, total mass, fat mass, lean mass, and percentage fat. Leg reflection and arm/leg dual-reflection caused significant changes to total mass, but the percentage change remained small. For infant spine DXA, fusion and omission caused no significant changes. Advanced analysis techniques reduced the failure rate of whole-body scanning from 20.8% to 9.3% and the failure rate of spine scanning from 8.9% to 2.4%. CONCLUSIONS: Advanced analysis techniques significantly reduced the impact of motion artifacts on infant DXA scans. We suggest this protocol be used in future infant DXA research and clinical practice.
Authors: Thomas N Hangartner; Sarah Warner; Pierre Braillon; Larry Jankowski; John Shepherd Journal: J Clin Densitom Date: 2013 Oct-Dec Impact factor: 2.617
Authors: Sanford Baim; Neil Binkley; John P Bilezikian; David L Kendler; Didier B Hans; E Michael Lewiecki; Stuart Silverman Journal: J Clin Densitom Date: 2008 Jan-Mar Impact factor: 2.617
Authors: John A Shepherd; Li Wang; Bo Fan; Vicente Gilsanz; Heide J Kalkwarf; Joan Lappe; Ying Lu; Thomas Hangartner; Babette S Zemel; Margaret Fredrick; Sharon Oberfield; Karen K Winer Journal: J Bone Miner Res Date: 2011-11 Impact factor: 6.741
Authors: Heidi J Kalkwarf; John A Shepherd; Bo Fan; Rashmi D Sahay; Richard F Ittenbach; Andrea Kelly; Kimberly Yolton; Babette S Zemel Journal: J Clin Endocrinol Metab Date: 2022-08-18 Impact factor: 6.134
Authors: Dan M Cooper; Gay L Girolami; Brenda Kepes; Annamarie Stehli; Candice Taylor Lucas; Fadia Haddad; Frank Zalidvar; Nitzan Dror; Irfan Ahmad; Antoine Soliman; Shlomit Radom-Aizik Journal: Pediatr Res Date: 2020-01-11 Impact factor: 3.756