M Khan1, J H Kuiper1, Christine Sieniawska2, J B Richardson1. 1. Institute of Orthopaedics, The Robert Jones and Agnes Hunt Orthopaedic and District Hospital, Oswestry, Shropshire SY10 7AG, United Kingdom. 2. Department of Clinical Biochemistry, University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, United Kingdom.
Abstract
BACKGROUND/AIMS: Cobalt and chromium are released from MOM hips and their precise nature (ions/particles) is not known. Their distribution in serum, plasma, and whole blood may help to determine their nature. METHODS: We measured cobalt and chromium concentrations in plasma, serum, and whole blood samples of patients with resurfacing MOM hips. RESULTS: We found that chromium concentration was highest in plasma, followed by serum and whole blood. Chromium and cobalt concentrations were higher in serum and plasma, compared to whole blood. CONCLUSION: We, therefore, suggest that in future cobalt and chromium concentrations shall be reported using plasma samples.
BACKGROUND/AIMS: Cobalt and chromium are released from MOM hips and their precise nature (ions/particles) is not known. Their distribution in serum, plasma, and whole blood may help to determine their nature. METHODS: We measured cobalt and chromium concentrations in plasma, serum, and whole blood samples of patients with resurfacing MOM hips. RESULTS: We found that chromium concentration was highest in plasma, followed by serum and whole blood. Chromium and cobalt concentrations were higher in serum and plasma, compared to whole blood. CONCLUSION: We, therefore, suggest that in future cobalt and chromium concentrations shall be reported using plasma samples.
Entities:
Keywords:
Chromium; Cobalt; Metal ions; Plasma; Serum
Authors: Munir Khan; Tomoki Takahashi; Jan H Kuiper; Christine E Sieniawska; Katsumasa Takagi; James B Richardson Journal: J Orthop Res Date: 2006-11 Impact factor: 3.494
Authors: Isabelle Catelas; J Dennis Bobyn; John B Medley; Jan J Krygier; David J Zukor; Olga L Huk Journal: J Biomed Mater Res A Date: 2003-10-01 Impact factor: 4.396