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Literature DB >> 27820801

Multidimensional chemical control of CRISPR-Cas9.

Basudeb Maji^1,2,3, Christopher L Moore^1,4, Bernd Zetsche^1,5,6,7, Sara E Volz^1,5,6,7, Feng Zhang^1,5,6,7, Matthew D Shoulders^1,4, Amit Choudhary^1,2,3.

Abstract

Cas9-based technologies have transformed genome engineering and the interrogation of genomic functions, but methods to control such technologies across numerous dimensions-including dose, time, specificity, and mutually exclusive modulation of multiple genes-are still lacking. We conferred such multidimensional controls to diverse Cas9 systems by leveraging small-molecule-regulated protein degron domains. Application of our strategy to both Cas9-mediated genome editing and transcriptional activities opens new avenues for systematic genome interrogation.

Entities: CellLine Chemical Disease Gene Species

Mesh：

Substances：
Transcription Factors

Year: 2016 PMID： 27820801 PMCID： PMC5531067 DOI： 10.1038/nchembio.2224

Source DB: PubMed Journal: Nat Chem Biol ISSN： 1552-4450 Impact factor: 15.040

29 in total

1. Crystal Structure of Staphylococcus aureus Cas9.

Authors: Hiroshi Nishimasu; Le Cong; Winston X Yan; F Ann Ran; Bernd Zetsche; Yinqing Li; Arisa Kurabayashi; Ryuichiro Ishitani; Feng Zhang; Osamu Nureki
Journal: Cell Date: 2015-08-27 Impact factor: 41.582

2. A split-Cas9 architecture for inducible genome editing and transcription modulation.

Authors: Bernd Zetsche; Sara E Volz; Feng Zhang
Journal: Nat Biotechnol Date: 2015-02 Impact factor: 54.908

Review 3. Genome editing. The new frontier of genome engineering with CRISPR-Cas9.

Authors: Jennifer A Doudna; Emmanuelle Charpentier
Journal: Science Date: 2014-11-28 Impact factor: 47.728

Review 4. Defining and improving the genome-wide specificities of CRISPR-Cas9 nucleases.

Authors: Shengdar Q Tsai; J Keith Joung
Journal: Nat Rev Genet Date: 2016-05 Impact factor: 53.242

5. Genome engineering using the CRISPR-Cas9 system.

Authors: F Ann Ran; Patrick D Hsu; Jason Wright; Vineeta Agarwala; David A Scott; Feng Zhang
Journal: Nat Protoc Date: 2013-10-24 Impact factor: 13.491

6. A rapid, reversible, and tunable method to regulate protein function in living cells using synthetic small molecules.

Authors: Laura A Banaszynski; Ling-Chun Chen; Lystranne A Maynard-Smith; A G Lisa Ooi; Thomas J Wandless
Journal: Cell Date: 2006-09-08 Impact factor: 41.582

7. Transportable, Chemical Genetic Methodology for the Small Molecule-Mediated Inhibition of Heat Shock Factor 1.

Authors: Christopher L Moore; Mahender B Dewal; Emmanuel E Nekongo; Sebasthian Santiago; Nancy B Lu; Stuart S Levine; Matthew D Shoulders
Journal: ACS Chem Biol Date: 2015-11-19 Impact factor: 5.100

8. Dynamic imaging of genomic loci in living human cells by an optimized CRISPR/Cas system.

Authors: Baohui Chen; Luke A Gilbert; Beth A Cimini; Joerg Schnitzbauer; Wei Zhang; Gene-Wei Li; Jason Park; Elizabeth H Blackburn; Jonathan S Weissman; Lei S Qi; Bo Huang
Journal: Cell Date: 2013-12-19 Impact factor: 41.582

9. RNA-guided gene activation by CRISPR-Cas9-based transcription factors.

Authors: Pablo Perez-Pinera; D Dewran Kocak; Christopher M Vockley; Andrew F Adler; Ami M Kabadi; Lauren R Polstein; Pratiksha I Thakore; Katherine A Glass; David G Ousterout; Kam W Leong; Farshid Guilak; Gregory E Crawford; Timothy E Reddy; Charles A Gersbach
Journal: Nat Methods Date: 2013-07-25 Impact factor: 28.547

10. Ligand-binding domains of nuclear receptors facilitate tight control of split CRISPR activity.

Authors: Duy P Nguyen; Yuichiro Miyaoka; Luke A Gilbert; Steven J Mayerl; Brian H Lee; Jonathan S Weissman; Bruce R Conklin; James A Wells
Journal: Nat Commun Date: 2016-07-01 Impact factor: 14.919

63 in total

1. Chemical Control of a CRISPR-Cas9 Acetyltransferase.

Authors: Jonathan H Shrimp; Carissa Grose; Stephanie R T Widmeyer; Abigail L Thorpe; Ajit Jadhav; Jordan L Meier
Journal: ACS Chem Biol Date: 2018-01-17 Impact factor: 5.100

2. Spatiotemporal Control of CRISPR/Cas9 Function in Cells and Zebrafish using Light-Activated Guide RNA.

Authors: Wenyuan Zhou; Wes Brown; Anirban Bardhan; Michael Delaney; Amber S Ilk; Randy R Rauen; Shoeb I Kahn; Michael Tsang; Alexander Deiters
Journal: Angew Chem Int Ed Engl Date: 2020-04-06 Impact factor: 15.336

Review 3. Approach for in vivo delivery of CRISPR/Cas system: a recent update and future prospect.

Authors: Yu-Fan Chuang; Andrew J Phipps; Fan-Li Lin; Valerie Hecht; Alex W Hewitt; Peng-Yuan Wang; Guei-Sheung Liu
Journal: Cell Mol Life Sci Date: 2021-01-03 Impact factor: 9.261

4. A Singular System with Precise Dosing and Spatiotemporal Control of CRISPR-Cas9.

Authors: Debasish Manna; Basudeb Maji; Soumyashree A Gangopadhyay; Kurt J Cox; Qingxuan Zhou; Benjamin K Law; Ralph Mazitschek; Amit Choudhary
Journal: Angew Chem Int Ed Engl Date: 2019-04-02 Impact factor: 15.336

5. CRISPR-Cas-Mediated Chemical Control of Transcriptional Dynamics in Yeast.

Authors: Daniel Cunningham-Bryant; Jingwen Sun; Brianna Fernandez; Jesse G Zalatan
Journal: Chembiochem Date: 2019-04-26 Impact factor: 3.164

6. Multidimensional Control of Cas9 by Evolved RNA Polymerase-Based Biosensors.

Authors: Jinyue Pu; Kaitlin Kentala; Bryan C Dickinson
Journal: ACS Chem Biol Date: 2017-08-22 Impact factor: 5.100

Review 7. Exploring the Trans-Cleavage Activity of CRISPR-Cas12a (cpf1) for the Development of a Universal Electrochemical Biosensor.

Authors: Yifan Dai; Rodrigo A Somoza; Liu Wang; Jean F Welter; Yan Li; Arnold I Caplan; Chung Chiun Liu
Journal: Angew Chem Int Ed Engl Date: 2019-10-17 Impact factor: 15.336