Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 A split-Cas9 architecture for inducible genome editing and transcription modulation.

Literature DB >> 25643054

A split-Cas9 architecture for inducible genome editing and transcription modulation.

Bernd Zetsche¹, Sara E Volz², Feng Zhang².

Abstract

Entities: CellLine Chemical Disease Gene Mutation Species

Mesh：

Substances：
Caspase 9

Year: 2015 PMID： 25643054 PMCID： PMC4503468 DOI： 10.1038/nbt.3149

Source DB: PubMed Journal: Nat Biotechnol ISSN： 1087-0156 Impact factor: 54.908

× No keyword cloud information.

10 in total

1. Characterization of the FKBP.rapamycin.FRB ternary complex.

Authors: Laura A Banaszynski; Corey W Liu; Thomas J Wandless
Journal: J Am Chem Soc Date: 2005-04-06 Impact factor: 15.419

2. Crystal structure of Cas9 in complex with guide RNA and target DNA.

Authors: Hiroshi Nishimasu; F Ann Ran; Patrick D Hsu; Silvana Konermann; Soraya I Shehata; Naoshi Dohmae; Ryuichiro Ishitani; Feng Zhang; Osamu Nureki
Journal: Cell Date: 2014-02-13 Impact factor: 41.582

3. Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex.

Authors: Silvana Konermann; Mark D Brigham; Alexandro E Trevino; Julia Joung; Omar O Abudayyeh; Clea Barcena; Patrick D Hsu; Naomi Habib; Jonathan S Gootenberg; Hiroshi Nishimasu; Osamu Nureki; Feng Zhang
Journal: Nature Date: 2014-12-10 Impact factor: 49.962

4. Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression.

Authors: Lei S Qi; Matthew H Larson; Luke A Gilbert; Jennifer A Doudna; Jonathan S Weissman; Adam P Arkin; Wendell A Lim
Journal: Cell Date: 2013-02-28 Impact factor: 41.582

5. Multiplex genome engineering using CRISPR/Cas systems.

Authors: Le Cong; F Ann Ran; David Cox; Shuailiang Lin; Robert Barretto; Naomi Habib; Patrick D Hsu; Xuebing Wu; Wenyan Jiang; Luciano A Marraffini; Feng Zhang
Journal: Science Date: 2013-01-03 Impact factor: 47.728

6. RNA-guided human genome engineering via Cas9.

Authors: Prashant Mali; Luhan Yang; Kevin M Esvelt; John Aach; Marc Guell; James E DiCarlo; Julie E Norville; George M Church
Journal: Science Date: 2013-01-03 Impact factor: 47.728

7. DNA targeting specificity of RNA-guided Cas9 nucleases.

Authors: Patrick D Hsu; David A Scott; Joshua A Weinstein; F Ann Ran; Silvana Konermann; Vineeta Agarwala; Yinqing Li; Eli J Fine; Xuebing Wu; Ophir Shalem; Thomas J Cradick; Luciano A Marraffini; Gang Bao; Feng Zhang
Journal: Nat Biotechnol Date: 2013-07-21 Impact factor: 54.908

8. RNA-guided gene activation by CRISPR-Cas9-based transcription factors.

Authors: Pablo Perez-Pinera; D Dewran Kocak; Christopher M Vockley; Andrew F Adler; Ami M Kabadi; Lauren R Polstein; Pratiksha I Thakore; Katherine A Glass; David G Ousterout; Kam W Leong; Farshid Guilak; Gregory E Crawford; Timothy E Reddy; Charles A Gersbach
Journal: Nat Methods Date: 2013-07-25 Impact factor: 28.547

9. Optical control of mammalian endogenous transcription and epigenetic states.

Authors: Silvana Konermann; Mark D Brigham; Alexandro Trevino; Patrick D Hsu; Matthias Heidenreich; Le Cong; Randall J Platt; David A Scott; George M Church; Feng Zhang
Journal: Nature Date: 2013-08-23 Impact factor: 49.962

10. Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation.

Authors: Luke A Gilbert; Max A Horlbeck; Britt Adamson; Jacqueline E Villalta; Yuwen Chen; Evan H Whitehead; Carla Guimaraes; Barbara Panning; Hidde L Ploegh; Michael C Bassik; Lei S Qi; Martin Kampmann; Jonathan S Weissman
Journal: Cell Date: 2014-10-09 Impact factor: 41.582

10 in total

243 in total

A split-Cas9 architecture for inducible genome editing and transcription modulation.

1. Characterization of the FKBP.rapamycin.FRB ternary complex.

2. Crystal structure of Cas9 in complex with guide RNA and target DNA.

3. Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex.

4. Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression.

5. Multiplex genome engineering using CRISPR/Cas systems.

6. RNA-guided human genome engineering via Cas9.

7. DNA targeting specificity of RNA-guided Cas9 nucleases.

8. RNA-guided gene activation by CRISPR-Cas9-based transcription factors.

9. Optical control of mammalian endogenous transcription and epigenetic states.

10. Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation.

Review 1. Combining CRISPR/Cas9 and rAAV Templates for Efficient Gene Editing.

2. Cell biology: delivering tough cargo into cells.

Review 3. Creating and evaluating accurate CRISPR-Cas9 scalpels for genomic surgery.

4. Very fast CRISPR on demand.

5. Crystal Structure of Staphylococcus aureus Cas9.

6. Self-assembled DNA nanoclews for the efficient delivery of CRISPR-Cas9 for genome editing.

Review 7. Precision Control of CRISPR-Cas9 Using Small Molecules and Light.

Review 8. CRISPR-Based Therapeutic Genome Editing: Strategies and In Vivo Delivery by AAV Vectors.

9. Small-molecule inducible transcriptional control in mammalian cells.

10. Engineered dCas9 with reduced toxicity in bacteria: implications for genetic circuit design.