Strain Imaging Echocardiography: What Imaging Cardiologists Should Know.

Despite recent advances in clinical imaging, echocardiography remains as the most accessible and reliable noninvasive. Since knowledge of left ventricular systolic function remains so critically important in determining prognosis; every effort should be made to prevent subjective estimations. The advent of strain imaging echocardiography now offers a readily available and portable imaging tool that not only offers an objective characterization of myocardial dynamics; but also allows for early detection of subclinical left ventricular dysfunction. This review outlines the basic concepts of strain imaging to better understand the mechanism of myocardial function as well their applicability in the least common cardiac diagnosis among current clinical practice. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

INTRODUCTION

For many years, conventional echocardiography has been the standard noninvasive imaging modality to assess left ventricular systolic function based on measures of left ventricular ejection fraction (LVEF). Unfortunately, a great majority of routine echocardiographic reports simply describe LVEF based on subjective visual estimates. This has prompted the American Society of Echocardiography to recommend the use of objective measures not only to standardize echocardiographic reading [1] but also to correctly identify serial changes in LVEF that are so critically related to early diagnosis and prognosis [2].

The newly recognized helical arrangement of left ventricle (LV) fibers as demonstrated by Torrent Guasp and further elaborated by Streeter is responsible for the torsional or wringing motion of the LV during contraction and further complicates accurate interpretations of LVEF even if objective conventional echocardiographic measures are used [3].

Strain and strain rate (SR) imaging have been recently shown not only to be readily available when performing advanced routine echocardiography but also invaluable in detecting subclinical LV systolic dysfunction in different clinical scenarios [4]. Therefore, in order to truly highlight the overall potential diagnostic value of strain and strain rate imaging as well as its impact on the management of specific cardiac conditions; not only it is crucial to have a better understanding of the physics of these imaging modalities, but also of the clinical applicability in routine practice. Hence, this work aims to review basic concepts and general applications in the least common cardiac entities, so that imaging cardiologist and any interested clinician may have a better understanding as to when these imaging tools might be clinically applicable.

STRAIN IMAGING BASICS

Basic Mechanical Definitions

The strain was first defined in isolated heart muscle and intact hearts in 1973 and it simply represents systolic deformation that occurs after the application of stress [5]. As a simple mathematical principle, strain is given by the following formula:

Where strain (ε), Lo the baseline length of the myocardium and L the length after systolic deformation [6]. Hence, given this relationship strain represents the fractional length change in one dimension. It is expressed in (%) units and it is considered positive when there is lengthening; however, negative with shortening [7].

It is important to remember that the heart is a three-dimensional organ with a complex fiber arrangement whose structure/function has been now well established based on the unfolding of the helical ventricular myocardial band with oblique fibers mainly found in the left ventricle arising from both descending and ascending segments of the myocardial band apical loop [8-10]. Consequently, when applying strain imaging it is important that there are three main spatial orientations of myocardial contraction associated with the left ventricle (Fig. ). First, longitudinal that occurs from base to apex as the mitral annulus contracts towards the left ventricular apex, denoted by negative strain as systolic contraction is occurring towards the ensonifying transducer located at the apex from the traditional four-chamber apical view. In contrast, when the oblique myocardial fibers are seen from the short axis view, based on the myocardial band arrangement, then two forms of contraction would be seen to result in myocardial thickening or the newly characterized “twisting motion” Second, radial contraction or relative thickening of the left ventricular wall towards the center that results in positive strain. Third, counterclockwise motion of the myocardial fibers as seen from base to apex with opposite clockwise rotation from apex to base to cause the “wringing motion” and effectively reduce the systolic left ventricular cavity size, known as circumferential shortening (seen as negative strain) (Figs. and ).

Obviously, in diastole, as the left ventricle relaxes and then assumes it's original resting state, myocardial motion not only would normally be in the opposite direction as that seen during systole; but also strain will be represented by an opposite strain designation. That is if the systolic strain was positive, then diastolic strain will be negative.

The difference between basal and apical segments strain is known as rotation and it is expressed in degrees per second [11].

On the other hand, strain rate (SR) simply represents the rate of deformation or stretch occurring over time and it is defined by the following formula [12]:

Where ΔV is the velocity gradient of the segment.

Both, strain and SR have the same direction. It is important to emphasize that deformation is load dependent; therefore, they are not direct measurements of myocardial contractility. Contractility represents the active state of the myocardial rather than loading conditions and is reflected by the stress/strain relationship [13]. Peak systolic SR is an early systolic event more closely related to myocardial contractility when compared with ejection fraction measured by conventional echocardiography. The reason behind this is the

fact that the final component of ejection fraction occurs by inertial effects once the myocyte contraction is finished [14].

Ultimately, an adequate understanding of these definitions not only is crucial to differentiate basic concepts of myocardial mechanics, but also to identify the potential utility as well as plausible limitations of echocardiography when imaging myocardial structures.

Advanced Strain Imaging Echocardiography

Three main echocardiographic modalities are currently available today, from different vendors, to perform advanced strain imaging assessment of myocardial function and basically include tissue Doppler imaging (TDI) and 2-D as well as 3-D speckle tracking imaging (STI).

Tissue Doppler Imaging

The initial concept of TDI was first applied to measure velocity displacement of both tricuspid and mitral annuli later found to be surrogate markers of the right ventricular and left ventricular systolic function, respectively [15-18].

This same Doppler technique was then applied to examine individual myocardial segments. Using TDI not only individual regions of myocardial tissue velocity were measured; but also myocardial strain or deformation analysis of those same segments was then possible.

Several studies have shown the utility of TDI not only in diagnosis subclinical cardiac disease but also in predicting adverse events [19-21]. However, TDI as a Doppler-based modality it’s bound by the same imaging limitations including angle dependence of the ultrasound beam. Therefore, when myocardial segments move out of the ensonifying beam line, inaccurate measurements are then obtained. In addition, the TDI-derived strain and SR is a time-consuming process and requires expert readers. Moreover, TDI parameters are very susceptible to signal noise [7]. Other important weakness of TDI is the influence of the tethering effect in getting the true strain or SR in hypokinetic myocardium. These limitations contribute to the measured 10-15% interobserver variability seen with TDI-derived strain and SR measurements [22].

Two-Dimensional Speckle Tracking

Two-dimensional speckle tracking echocardiography (2-D-STE) tracks frame-to-frame movements of the natural acoustic markers or speckles observed on myocardial tissue as a result of high-resolution frame rate imaging [23]. Unlike TDI, this modality tracks in two dimensions along the direction of the wall, thus is relatively angle independent and appears to be more reproducible [24]. This 2-D-STE-derived SR is calculated through temporal derivation of 2-D strain data and its spatial integration will show 2-D myocardial velocities [7]. Another important limitation of 2-D-STE is the need of high-resolution imaging quality; consequently, measurements are significantly limited with tachycardia (Fig. ).

Three-Dimensional Speckle Tracking

Three-dimensional speckle tracking (3-D-STE) is a novel echocardiographic modality based on acquiring a 3D volumetric echocardiographic rendition of the left ventricle, generally from the apical widow [25]. This 3D full-volume LV data acquisition should overcome the limitation of plane dependency of 2D imaging [26].

Even though 3-D-STE has been validated against sonomicrometry, current guidelines are still not widely available and its use in routine clinical practice is still limited to some major centers or for research purposes [27].

Some limitations of 3-D-STE are the high vendor and imaging quality dependency [25, 28]. However, area strain appears to be a highly accurate parameter to assess myocardial deformation, as combined data for 2 directional deformations can reduce the tracking error because of higher signal-noise ratio compared with that of longitudinal and circumferential strain.

CLINICAL APPLICATIONS

Strain or strain imaging has shown to be valuable in several clinical scenarios in cardiology. Although many applications have been reported in the most frequent cardiac entities seen in the clinical practice (e.g., hypertensive heart disease, coronary artery disease, LV dysfunction caused by valvular heart disease or heart failure); some applications for the least common cardiac diagnosis remain unknown to the imaging cardiologist.

Cardiac Dyssynchrony

One of the first clinical applications of TDI and STE were to assess temporal differences in the generation of maximal systolic deformation among different myocardial segments in patients with dilated left ventricles (Fig. ). The concept of cardiac resynchronization therapy (CRT) was then introduced to find if echocardiography would be useful in identifying these segments and using pacing therapy resynchronize those myocardial segments with the largest temporal difference with regards to strain generation in order to reduce symptomatology and improves survival [29, 30]. The American Heart Association/American College of Cardiology/ European Society of Cardiology and the Heart Rhythm Society had agreed that CRT should be undoubtedly offered to patients with the following profile including those with continuing symptoms of heart failure despite optimal therapy, a left bundle branch block morphology with a QRS duration ≥ 120 ms, a left ventricular ejection fraction < 35% and patients have to be in normal sinus rhythm [31-33]. Despite these indications, there is a low responder rate among these patients and still remains uncertain the influences of biventricular pacing over myocardial mechanics [34], mainly because even though dyssynchronous myocardial segments might be identified, placement of a pacing wire on those segments might be technically challenging.

Thus, this field continues to evolve despite the unquestionably proven benefit of STE in the assessment of both dyssynchrony and myocardial function. Suffoleto et al. reported that baseline radial STE dyssynchrony (time difference in peak septal wall-to-posterior wall strain > or =130 ms) predicted an immediate and long-term significant increase in ejection fraction after CRT placement with a 91% sensitivity/ 75% specificity and 89% sensitivity/ 83% specificity respectively [35]. Later on, several other studies have validated these same findings and at present it is clear that radial strain is the best directional strain parameters to identify CRT responders [36-38].

More recently, apical transverse motion (ATM), to quantify “apical rocking”, has been proposed as a novel parameter for assessing LV dyssynchrony and predicting response to CRT. In a study of 35 patients with non-ischemic dilated cardiomyopathy, ATM revealed a significant correlation with radial dyssynchrony (r=0.78, p<0.001). In addition, a cut-off value of 2.5 mm for ATMloop was recommended to discriminate between patients with and without radial dyssynchrony [39].

On the other hand, there is some evidence that LV lead position is optimal at the site of latest mechanical activation and away from possible areas of a scar, which it is known that may affect the response to CRT [40]. Becker et al. proved that an adequate lead position defined by circumferential strain analysis results in significant improvement in LV function and more LV reverse remodeling [41]. The same results were recently found in the TARGET (Targeted Left Ventricular Lead Placement to Guide Cardiac Resynchronization Therapy) Trial were 250 patients were evaluated. An optimal LV lead position at the site of latest mechanical activation, avoiding low strain amplitude (scar), was correlated with a better CRT response and survival. Furthermore, a suboptimal LV lead placement independently predicted all-cause mortality (hazard ratio: 1.8; p = 0.024) [42].

Three-dimensional STE imaging has emerged as a useful modality when compared to either 2-D-STE or TDI for the ongoing evaluation of LV dyssynchrony [43]; however, prediction of both responses to CRT and LV reverse remodeling requires more studies with prospective data [44, 45].

Athlete’s Heart

Regular intense exercise training is known to result in increased left ventricular wall thickness and mass as well as cavity dilatation known as athlete’s heart [46]. Athletes participating in high endurance sports are usually affected with cardiac hypertrophy. This particular finding of LV hypertrophy could be particularly troublesome when LV hypertrophy is also the hallmark of hypertrophic cardiomyopathy (HCM), the most common of sudden cardiac death. Therefore, it would be critically important to differentiate both conditions in order to allow participation of young athletes in competitive sports. In addition, young patients with unrecognized hypertension might also have left ventricular hypertrophy and have similar echocardiographic findings. However, this form of hypertensive hypertrophy is also associated with increased morbidity and mortality.

STE has been particularly useful in differentiating pathologic from physiologic hypertrophy in top-level athletes. In study by Butz and associates STE was used to study deformation differences between top-level athletes and HCM as well as sedentary normal subjects. In this study, these investigators found that all strain components in HCM patients were significantly reduced. In this study, a cut-off value of < -10% for peak global longitudinal strain (GLS) identified pathologic hypertrophy due to HCM with a sensitivity of 80.0% and a specificity of 95.0% [47].

In another study assessing long-term cardiac remodeling, marathon runners and wrestlers who had quit sports after an extensive period of time were evaluated using standard echocardiographic and STE parameters and their data was then compared to that of healthy subjects. In this study, wrestlers maintained both structural and functional properties despite having stopped the sports more than 10 years earlier. In wrestlers, LV global longitudinal strain and systolic strain rate values - although within normal limits- were significantly higher when compared with marathon runners and control group. The reason for these differences when compared with runners is still unknown. However, they could not detect the magnitude of such changes due to the lack of data during their active sports periods [48]. In another study by Simsek et al. STE was found more useful than conventional echocardiography in characterizing LV systolic and diastolic function that both should be normal in young elite athletes when eccentric and concentric hypertrophy was present in contrast to pathological hypertrophy that both might be abnormal [49].

In addition, since the right ventricle (RV) also determines exercise tolerance by using STE preserved RV systolic function is also a normal criteria found among athletes when performing high-intensity chronic exertion [50].

Finally, left atrial enlargement with normal left diastolic function is a common finding in athletes. Using STE, both left atrial global peak atrial longitudinal strain (43.9 ± 9.5% versus 39.8 ± 6.5%; P<0.05) and peak atrial contraction strain (15.5 ± 4.0% versus 13.9 ± 4.0%; P<0.05) were found to be significantly decreased after 16 weeks of intensive training. However, no changes were observed in biventricular E/e’ ratio and atrial stiffness, suggesting that left atrial remodeling had a strong volume rather than a pressure overload component [51].

When comparing 2D to 3D STE in characterizing athlete’s heart, so far no significant differences have been identified [52]. However, studies are limited to a small number of patients; hence, differences between these two images modalities might be noted when more studies become available.

Acute Rejection in Cardiac Transplantation

Acute allograft rejection still remains a significant cause of mortality in post heart transplant recipients [53]. At the moment, there is no reliable noninvasive method to detect cardiac transplant rejection (CTR) aside from endomyocardial biopsy that remains as the “gold standard” invasive method for definitive diagnosis [54]. The advent of STE has been proposed as a possible alternative tool to monitor cardiac allograft function and define the best time to perform myocardial biopsies as well as coronary angiography [22]. Significant data is currently available showing significant advantages of STE over conventional echocardiography in identifying acute-subclinical rejection (including asymptomatic patients with histological evidence of rejection); hence it has now become an essential imaging tool in the follow-up of patients after cardiac transplant [55].

Buddhe et al., in a study of 50 children with heart transplant undergoing routine cardiac catheterization found a better correlation between diastolic function parameters by STE and pulmonary capillary wedge pressure, when compared with conventional echocardiography [56]. Furthermore, 24% of children were found having an abnormal global longitudinal peak systolic strain despite normal parameters reported on conventional echocardiography. Thus, changes in global longitudinal peak systolic strain appear to be more common than previously thought in pediatric heart transplant recipients with no acute heart rejection. In support of this theory, a recent study reported by Clemmensen et al. recognized the importance of global longitudinal strain in detecting moderate rejection in adults, providing solid evidence to consider GLS as a marker of graft function involvement during acute rejection [57]. Moreover, other strain parameters such as peak systolic longitudinal, radial and circumferential strain have been proposed to be useful in detecting acute allograft rejection in children [54].

Finally, LV torsion (LV-tor) measured by STE has been preliminarily shown of clinical value for monitoring acute rejection cardiac transplant recipients. Specifically, a 25% reduction in LV-tor value from baseline was noted to be a good predictor of Grade 2 or higher rejection with an accuracy of 92.2% [58]. Furthermore, despite being not only a retrospective but also small study neither the individual use of longitudinal or radial strain nor torsion were useful in detecting vasculopathy among heart transplant recipients [59]. However, more data is certainly needed before any definitive conclusions can be reached.

Chemotherapy-Induced Cardiotoxicity

Since antitumor drugs have significantly decreased mortality and consequently enhanced survival rates of many cancer patients; it has now become apparent that these same survivors are experiencing serious cardiotoxic effects, clinically recognized as irreversible cardiac injury and symptomatic heart failure. In fact, cardiotoxicity induced by certain chemotherapeutic agents commonly used for certain cancers represents the leading cause of morbidity and mortality in cancer survivors [60].

Therefore, baseline determination of LVEF and most importantly close surveillance remain critically important in the management of cancer patients. Traditionally, imaging modalities such as nuclear-based multigated acquisition (MUGA) scans and conventional echocardiography were recommended for assessment of LVEF. Unfortunately, subtle identification of a reduction in LVEF by any of these two imaging tools to conclusively determine that myocardial damage has occurred as a result of chemotherapy might not occur and when it does it may be too late. It has been estimated that progression of cardiac injury has already occurred in up to 58% of patients and even though aggressive heart failure therapy might be initiated, most of these patients not only their systolic function fails to recover, but also they continue to deteriorate [61, 62].

Since STE has been recently shown not only to be readily available when performing advanced routine echocardiography but also its value in detecting subclinical ventricular dysfunction, as well as its prognostic value in several clinical scenarios [63]; its use has also been investigated in cancer patients. In a recent literature review, involving a total of 1,504 patients, the overall utility of STE in measuring myocardial deformation in the diagnosis and prediction of cardiotoxicity in patients receiving potentially cardiotoxic chemotherapy was assessed and initial results seemed promising. Specifically, peak systolic longitudinal strain rate was consistently shown to detect early myocardial changes during therapy. In this analysis, a 10% to 15% early reduction in GLS by STE during therapy was the most useful parameter for cardiotoxicity prediction, defined as a drop in LVEF or development of heart failure symptoms. In late survivors of cancer, measures of global radial and circumferential strain were consistently abnormal, even when LVEF was normal [64]. Most recently, when peak left ventricular GLS was added to standard clinical variables used in the routine follow-up of cancer patients with normal ejection fractions receiving chemotherapy; incremental prognostic information was obtained regarding mortality in these patients [65].

In 2014, Florescu et al., studying the effects of Epirubicin in potentially inducing cardiotoxicity in 40 patients with breast cancer found that the systolic TDI velocity (S'), longitudinal strain, and longitudinal strain rate were all abnormally low only after the third cycle of epirubicin, even though radial and circumferential strain measures, as well as rotation parameters were still normal. Furthermore, a decrease in longitudinal strain after the third cycle of epirubicin was identified as the best independent and accurate predictor of cardiotoxicity after completion of epirubicin-induced cardiotoxicity [66].

To date, the St. Jude Lifetime Cohort Study represents the largest study focusing on the utility of GLS in identifying late cardiotoxicity in cancer survivors [67]. This cross-sectional study was performed in 1,807 childhood survivors diagnosed whose cancers were previously diagnosed and treated with anthracycline chemotherapy, chest radiotherapy or both more than 10 years prior to their follow-up data. These investigators found that 28% had preserved LV function while 8.7% of patients had abnormal GLS as well as evidence of left ventricular diastolic dysfunction. Obviously, these findings highlight the importance of identifying subtle abnormalities of systolic and diastolic function that might be present in asymptomatic cancer survivors when compared with the normal population that would otherwise not be treated if correctly identified with the appropriate imaging tool [68].

Hypertrophic Cardiomyopathy

HCM is an autosomal dominant disease in which part of the left ventricle (and sometimes of the right ventricle) is hypertrophied by an unclear cause with associated myocyte disarray and fibrosis [69]. It was first called a “disease of the sarcomere” when the first three disease genes to be identified were discovered to encode part of the myocardium [70]. Single-points missense mutations in one of nine sarcomeric genes encoding sarcomeric proteins have been proposed to cause the disease and have been described in up to 2/3 of patients with HCM [71]. The genes MYBPC3, encoding cardiac myosin-binding protein C (cMyBP-C) and MYH7, encoding the β-myosin heavy chain are often the most frequent target of mutations, each accounting for 1/4 to 1/3 of all cases diagnosed [72].

HCM is the most prevalent inheritable myocardial disease and cause of left ventricular outflow tract LVOT obstruction as the latter is present in the majority of patients with HCM (±70%) [73]. Not only is LVOT obstruction associated with a diversity of symptoms such as dyspnea on exertion, syncope, chest pain, and general fatigue, but previous studies have also shown an associated increase of all-cause mortality and sudden cardiac death in these patients [74, 75]. Consequently, the HCM Outcomes Investigators have incorporated the presence of obstruction as a risk factor in the novel clinical risk prediction model [76].

To date, several studies have confirmed LV systolic dysfunction as measured by left ventricular torsion and strain imaging is present in HCM despite normal measurements by conventional echocardiography [77, 78]. Specifically, when STE was used to study HCM subjects with preserved LVEF, peak GLS was shown to be lower when compared with healthy group [79]. Furthermore, even though endocardial global circumferential strain (GCS) was no different; the ratio of endocardial GCS strain to epicardial GCS strain was significantly increased in the HCM group. The investigators proposed a possible initial involvement of subendocardial fibers as a plausible mechanism causing early LV dysfunction in HCM patients. In another study in which 41 patients with HCM were compared to 27 control subjects, not only peak GLS of all layers was reduced, but also peak GCS of the mid and outer layers were also decreased, presumably reflecting impaired myocardial function. In this other study, peak GCS of the inner layer was preserved, being associated with maintenance of chamber function [80]. Therefore, peak GLS has been proposed as a promising predictor of adverse cardiovascular outcomes which may provide additional benefit over conventional variables for risk stratification in HCM patients [81].

Furthermore, the use of left atrial STE strain analysis has been shown the ability to discriminate between HCM mutation carriers and healthy individuals, even though no significant differences in LV systolic deformation were identified between these two groups [82]. Hence, STE could be considered as an alternative family screening approach for early identification of HCM mutation carriers.

Finally, Zhang H et al. found that LV twist also had a high discriminatory power in detecting extent of myocardial fibrosis in HCM patients, pointing at LV twist as a potential additional marker not only for detection of myocardial fibrosis; but also as a predictor of major cardiac events in these patients [83].

Cardiac Amyloidosis

Amyloidosis is a rare disease characterized by extracellular accumulation of amyloid fibrils in organs and tissues [84]. Misfolded protein aggregates compose these insoluble rigid, nonbranching fibrils that end up depositing within the extracellular space, leading to an abnormal tissue architecture and ultimately, a loss of function [85, 86]. To date, twenty-seven different amyloid precursor proteins, have been pointed out to be involved in the amyloid fibril formation and tissue/organ deposition [87]. However, despite this diversity of precursors, it is almost impossible to distinguish the final resulting fibrils. The final diagnosis of amyloidosis is based on pathology specimens identification of amyloid fibril deposition with Congo red, thioflavin T, or Alcian blue staining [86].

Cardiac amyloidosis (CA) is characterized by heart amyloid deposition, including the atria, ventricles, perivascular space and in some cases, the valves and conduction system [88]. It might be present in up to 50% of patients with systemic amyloidosis and it represents the major cause of mortality in light-chain subtype disease [89] (Fig. ). Amyloid infiltration can lead to loss of heart elasticity (impaired relaxation) due to the resulting biventricular wall thickening; which is clinically translated in restrictive cardiomyopathy.

Cardiac amyloidosis has been traditionally viewed as a rare or orphan disease, particularly compared with acquired cardiovascular diseases such as coronary artery disease and hypertensive heart disease. Ongoing efforts have suggested, though, that the rarity of cardiac amyloidosis may be more a reflection of its underdiagnosis, rather than true incidence. This may be particularly true in the transthyretin amyloidoses. In general, diagnosis of amyloid cardiomyopathy has proven to be quite challenging, requiring cardiac biopsy and pathological evaluation for a definitive histological diagnosis in many patients. Cardiac involvement is probably often misdiagnosed during the early stages of the disease when ventricular wall thickening due to amyloid infiltration may be misdiagnosed as left ventricular hypertrophy due to hypertension. In patients with confirmed amyloid deposition in other organ systems, wall thickening on echocardiography, particularly if associated with low voltage on the electrocardiogram, is highly suggestive of cardiac involvement, and cardiac biopsy is rarely needed in such cases [88].

In early subclinical disease, STE have shown to provide more detailed information on regional myocardial deformation when compared with conventional echocardiography [90]. In this context, Sun et al demonstrated that cardiac amyloid strongly alters all strain parameters (longitudinal, circumferential, and radial strain) and STE can differentiate cardiac Amyloidosis from other causes of LV hypertrophy, including HCM [91]. Baccouche et al. obtained similar results by 3D STE but emphasized in oppositional basoapical radial strain gradient as suggestive of a “function-pattern-based” differentiation of amyloidosis and HCM [92]. Furthermore, parametric polar maps of regional longitudinal strain have been proposed to detect regional variations in strain parameters which represent an accurate tool to discriminate cardiac amyloidosis and HCM from hypertensive heart disease [93].

In 2012, Phelan et al. compared 55 CA patients with 30 control diagnosed with LV hypertrophy. They found a variation pattern in longitudinal strain from base to apex among patients diagnosed with CA. This study demonstrated that relative “apical sparing” pattern of longitudinal strain represents an important parameter that should be considered in the diagnosis of cardiac amyloidosis, being sensitive (93%) and specific (82%) enough in discriminating case from controls. [94].

Moreover, selected strain parameters can predict outcomes in cardiac amyloidosis. A recent study shows that early diastolic strain rate was a powerful independent predictor of outcomes in cardiac Amyloidosis patients with preserved LVEF [95]. Buss et al. reported similar results in a study of 206 patients with light-chain amyloidosis where diastolic dysfunction and 2D global longitudinal strain served as independent predictors of survival in patients with primary amyloidosis and offered incremental information beyond standard clinical and serological parameters [96].

Cardiac Sarcoidosis

Sarcoidosis is a systemic granulomatous disease of unknown etiology with direct involvement of the heart in more than 20% of affected patients [97-100]. Cardiac Sarcoidosis (CS) is frequently recognized post-mortem, as sudden death may be the clinical presentation [101-104]. To date, the experts in the field have failed to fully agree with the best diagnosis criteria and choice of therapy [105, 106].

The incidence of CS is influenced by race and ethnicity. In Japan, 50-78% of patients with sarcoidosis shown cardiac involvement in necropsy studies [107-111]. Between 77 to 85% of deaths in these patients have been attributed to CS, which has defined cardiac involvement as the leading cause of death due to sarcoidosis [109, 112]. By contrast, in the United States, 13 to 50% of sarcoid deaths have been attributed to myocardial involvement [101, 113].

Overall, when CS is present, overall prognosis is adversely affected and mortality increases as a result of fatal arrhythmia, atrioventricular conduction disturbances, and congestive heart failure. Unfortunately, when these events occur, most of the patients haven’t shown typical cardiovascular symptoms or structural abnormalities by basic cardiac testing and there was no time to establish an adequate intervention [114]. Since steroid therapy plays a critical role in cardioprotection and LV systolic function preservation, prompt detection of subclinical myocardial dysfunction in cardiac Sarcoidosis is crucial [115].

Further insights of subclinical myocardial involvement by CS can be gained with the use of STE. In a recent study, 40 patients with sarcoidosis and normal EF had evidence of bi-ventricular and atrial mechanical dysfunction as seen by STE [116]. Other investigators also found significant reduction in peak GLS in 67 newly diagnosed patients without symptoms or signs of cardiac disease, when compared to healthy control patients [117]. Furthermore, peak global radial strain was also found to be useful in differentiating patients with cardiac sarcoidosis from those with dilated cardiomyopathy [118].

Despite the harmful effects of CS on patient survival, few studies have explored the usefulness of STE in detecting subclinical disease and predicting clinical outcomes. Therefore, additional studies are necessarily warranted to advance our understanding of cardiac mechanics and identify if STE has a significant role in diagnosis and follow-up of patients with sarcoidosis.

FUTURE DIRECTIONS

Although innumerable publications have appeared to date regarding strain and strain rate, STI has yet to gain great acceptance into routine clinical practice. STE by itself is a robust technique that enables assessment of the deformation of the myocardium noninvasively and quantitatively. Sure STI has allowed us to gain a better understanding of myocardial mechanics; however, there are other areas that remain to be validated. Specifically, care should be taken, for example, when comparing strain measurements from very dilated to small left ventricles; presence of severe valvular stenosis or regurgitation; uncontrolled hypertension at the time of the study; left ventricles with concentric versus eccentric hypertrophy, etc. Though these limitations need to be acknowledged; examination of the same individual over time might be useful, particularly when considering the clinical scenarios mentioned in this review. As previously suggested by many, if strain could be quantitatively normalized to the wall stress, strain would become by far the clinically relevant pathophysiologic parameter to access myocardial function. Moreover, the addition of other imaging techniques such as cardiac computed tomography and magnetic resonance imaging in combination with STI, represent a promising field in the diagnosis, prognosis and management of cardiac disease. Undoubtedly, we all need to continue participating in this type of research.

CONCLUSION

STE is a robust non-Doppler, and thereby angle-independent technique, for the assessment of regional and global deformation of the myocardium. Although, STE-derived strain and strain rate measurements have several limitations, implementation of these advanced imaging tools on a routine basis; particularly in certain clinical settings as mentioned in this review not only will be of great diagnostic and therapeutic value, but also advance of understanding of these clinical entities.