Kursat Tigen1, Murat Sunbul2,3, Tansu Karaahmet4, Onur Tasar5, Cihan Dundar5, Murat Yalcinsoy6, Mumtaz Takir7, Esen Akkaya6. 1. Department of Cardiology, Marmara University Faculty of Medicine, Istanbul, Turkey. 2. Department of Cardiology, Marmara University Faculty of Medicine, Istanbul, Turkey. drsunbul@yahoo.com.tr. 3. Marmara University Education and Research Hospital, Fevzi Cakmak Mahallesi, Muhsin Yazicioglu Caddesi, No: 10, Pendik, Istanbul, Turkey. drsunbul@yahoo.com.tr. 4. Department of Cardiology, Acibadem University Faculty of Medicine, Istanbul, Turkey. 5. Department of Cardiology, Kartal Kosuyolu Heart Training and Research Hospital, Istanbul, Turkey. 6. Pulmonary Medicine Clinic, Sureyyapasa Chest Diseases and Thoracic Surgery Training and Research Hospital, Istanbul, Turkey. 7. Department of Endocrinology, Faculty of Medicine, Istanbul Medeniyet University, Istanbul, Turkey.
Abstract
PURPOSE: Sarcoidosis is a systemic inflammatory disease with unknown etiology involving several organs. Myocardial involvement, pericarditis, severe rhythm abnormalities, and heart valve disease due to papillary muscle dysfunction are some of the cardiac manifestations. Conventional echocardiographic methods remain insufficient for the determination of subclinical myocardial dysfunction in patients with sarcoidosis. In our study, we investigated the impact of sarcoidosis on bi-ventricular and atrial functions using two-dimensional (2D) speckle tracking echocardiography (STE). METHODS: Forty patients with sarcoidosis and 20 age and sex-matched controls were recruited into study. All subjects underwent a transthoracic echocardiography for the evaluation of ventricular and atrial functions with 2D STE. RESULTS: Left ventricular (LV) dimensions, LV ejection fraction, and right ventricular (RV) systolic velocity were similar between the two groups. Left atrial (LA) diameter was significantly higher in sarcoidosis patients than controls. Eighteen (45%) patients in the sarcoidosis group and 1 (5%) patient in the control group had LV diastolic dysfunction. LV global longitudinal, radial, circumferential strain, twist, untwists, and RV global longitudinal strain values were significantly lower in sarcoidosis patients compared to controls. LA and RA reservoir functions were also significantly lower in sarcoidosis patients than controls. CONCLUSION: Although impaired LV diastolic function was detected using conventional parameters, only novel advanced echocardiographic modalities demonstrated impaired bi-ventricular and atrial mechanical functions in patients with sarcoidosis.
PURPOSE:Sarcoidosis is a systemic inflammatory disease with unknown etiology involving several organs. Myocardial involvement, pericarditis, severe rhythm abnormalities, and heart valve disease due to papillary muscle dysfunction are some of the cardiac manifestations. Conventional echocardiographic methods remain insufficient for the determination of subclinical myocardial dysfunction in patients with sarcoidosis. In our study, we investigated the impact of sarcoidosis on bi-ventricular and atrial functions using two-dimensional (2D) speckle tracking echocardiography (STE). METHODS: Forty patients with sarcoidosis and 20 age and sex-matched controls were recruited into study. All subjects underwent a transthoracic echocardiography for the evaluation of ventricular and atrial functions with 2D STE. RESULTS: Left ventricular (LV) dimensions, LV ejection fraction, and right ventricular (RV) systolic velocity were similar between the two groups. Left atrial (LA) diameter was significantly higher in sarcoidosispatients than controls. Eighteen (45%) patients in the sarcoidosis group and 1 (5%) patient in the control group had LV diastolic dysfunction. LV global longitudinal, radial, circumferential strain, twist, untwists, and RV global longitudinal strain values were significantly lower in sarcoidosispatients compared to controls. LA and RA reservoir functions were also significantly lower in sarcoidosispatients than controls. CONCLUSION: Although impaired LV diastolic function was detected using conventional parameters, only novel advanced echocardiographic modalities demonstrated impaired bi-ventricular and atrial mechanical functions in patients with sarcoidosis.
Entities:
Keywords:
Atrial function; Sarcoidosis; Speckle tracking echocardiography; Ventricular function
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