R L Saute1,2, R B Soder1,2, J O Alves Filho1,3, M Baldisserotto1,2, A R Franco1,2,3. 1. PUCRS, Brain Institute (BraIns), Porto Alegre, Brazil. 2. PUCRS, Faculdade de Medicina, Porto Alegre, Brazil. 3. PUCRS, Faculdade de Engenharia, Porto Alegre, Brazil.
Abstract
BACKGROUND: There has been a growing amount of evidence indicating that excess visceral fat is associated with alterations in brain structure and function, including brain cortical thinning in adults. OBJECTIVES: This study aims to investigate the relationship between brain cortical thickness with obesity assessments, in adolescents. METHODS: In this study, we measured three different obesity assessments within an adolescent population (aged 15 - 18 years): body mass index (BMI), visceral fat ratio measured with an MRI and hepatorenal gradient measured with an ultrasound. Volunteers also underwent an MRI scan to measure brain structure. RESULTS: Results indicated that there was no relationship of BMI or hepatorenal gradient with brain cortical dimensions. However, there was a significant association between visceral fat ratio and an increase of cortical thickness throughout the brain. CONCLUSIONS: These results suggest that visceral fat, but not BMI, is correlated with cortical thickening in adolescence.
BACKGROUND: There has been a growing amount of evidence indicating that excess visceral fat is associated with alterations in brain structure and function, including brain cortical thinning in adults. OBJECTIVES: This study aims to investigate the relationship between brain cortical thickness with obesity assessments, in adolescents. METHODS: In this study, we measured three different obesity assessments within an adolescent population (aged 15 - 18 years): body mass index (BMI), visceral fat ratio measured with an MRI and hepatorenal gradient measured with an ultrasound. Volunteers also underwent an MRI scan to measure brain structure. RESULTS: Results indicated that there was no relationship of BMI or hepatorenal gradient with brain cortical dimensions. However, there was a significant association between visceral fat ratio and an increase of cortical thickness throughout the brain. CONCLUSIONS: These results suggest that visceral fat, but not BMI, is correlated with cortical thickening in adolescence.
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