PURPOSE: Childhood obesity is a global health concern, with >340 million youth considered overweight or obese. In addition to contributing greatly to health care costs, excess adiposity associated with obesity is considered a major risk factor for premature mortality from cardiovascular and metabolic diseases and is also negatively associated with cognitive and brain health. A complementary line of research highlights the importance of cardiorespiratory fitness, a by-product of engaging in physical activity, on an abundance of health factors, including cognitive and brain health. METHODS: This study investigated the relationship among excess adiposity (visceral adipose tissue [VAT], subcutaneous abdominal adipose tissue), total abdominal adipose tissue, whole-body percent fat [WB%FAT], body mass index (BMI), and fat-free cardiorespiratory fitness (FF-V̇O 2max ) on resting-state functional connectivity (RSFC) in 121 ( f = 68) children (7-11 yr) using a data-driven whole-brain multivoxel pattern analysis. RESULTS: Multivoxel pattern analysis revealed brain regions that were significantly associated with VAT, BMI, WB%FAT, and FF-V̇O 2 measures. Yeo's (2011) RSFC-based seven-network cerebral cortical parcellation was used for labeling the results . Post hoc seed-to-voxel analyses found robust negative correlations of VAT and BMI with areas involved in the visual, somatosensory, dorsal attention, ventral attention, limbic, frontoparietal, and default mode networks. Further, positive correlations of FF-V̇O 2 were observed with areas involved in the ventral attention and frontoparietal networks. These novel findings indicate that negative health factors in childhood may be selectively and negatively associated with the 7 Yeo-defined functional networks, yet positive health factors (FF-V̇O 2 ) may be positively associated with these networks. CONCLUSIONS: These novel results extend the current literature to suggest that BMI and adiposity are negatively associated with, and cardiorespiratory fitness (corrected for fat-free mass) is positively associated with, RSFC networks in children.
PURPOSE: Childhood obesity is a global health concern, with >340 million youth considered overweight or obese. In addition to contributing greatly to health care costs, excess adiposity associated with obesity is considered a major risk factor for premature mortality from cardiovascular and metabolic diseases and is also negatively associated with cognitive and brain health. A complementary line of research highlights the importance of cardiorespiratory fitness, a by-product of engaging in physical activity, on an abundance of health factors, including cognitive and brain health. METHODS: This study investigated the relationship among excess adiposity (visceral adipose tissue [VAT], subcutaneous abdominal adipose tissue), total abdominal adipose tissue, whole-body percent fat [WB%FAT], body mass index (BMI), and fat-free cardiorespiratory fitness (FF-V̇O 2max ) on resting-state functional connectivity (RSFC) in 121 ( f = 68) children (7-11 yr) using a data-driven whole-brain multivoxel pattern analysis. RESULTS: Multivoxel pattern analysis revealed brain regions that were significantly associated with VAT, BMI, WB%FAT, and FF-V̇O 2 measures. Yeo's (2011) RSFC-based seven-network cerebral cortical parcellation was used for labeling the results . Post hoc seed-to-voxel analyses found robust negative correlations of VAT and BMI with areas involved in the visual, somatosensory, dorsal attention, ventral attention, limbic, frontoparietal, and default mode networks. Further, positive correlations of FF-V̇O 2 were observed with areas involved in the ventral attention and frontoparietal networks. These novel findings indicate that negative health factors in childhood may be selectively and negatively associated with the 7 Yeo-defined functional networks, yet positive health factors (FF-V̇O 2 ) may be positively associated with these networks. CONCLUSIONS: These novel results extend the current literature to suggest that BMI and adiposity are negatively associated with, and cardiorespiratory fitness (corrected for fat-free mass) is positively associated with, RSFC networks in children.
Authors: Patricio Solis-Urra; Irene Esteban-Cornejo; Cristina Cadenas-Sanchez; Maria Rodriguez-Ayllon; Jose Mora-Gonzalez; Jairo H Migueles; Idoia Labayen; Juan Verdejo-Román; Arthur F Kramer; Kirk I Erickson; Charles H Hillman; Andrés Catena; Francisco B Ortega Journal: Neuroimage Date: 2019-08-26 Impact factor: 6.556
Authors: M W Voss; L Chaddock; J S Kim; M Vanpatter; M B Pontifex; L B Raine; N J Cohen; C H Hillman; A F Kramer Journal: Neuroscience Date: 2011-10-14 Impact factor: 3.590
Authors: Irene Esteban-Cornejo; Chelsea M Stillman; María Rodriguez-Ayllon; Arthur F Kramer; Charles H Hillman; Andrés Catena; Kirk I Erickson; Francisco B Ortega Journal: Brain Behav Immun Date: 2020-10-10 Impact factor: 7.217
Authors: Juan Pablo Zavala-Crichton; Irene Esteban-Cornejo; Patricio Solis-Urra; José Mora-Gonzalez; Cristina Cadenas-Sanchez; María Rodriguez-Ayllon; Jairo H Migueles; Pablo Molina-Garcia; Juan Verdejo-Roman; Arthur F Kramer; Charles H Hillman; Kirk I Erickson; Andrés Catena; Francisco B Ortega Journal: J Clin Med Date: 2020-04-12 Impact factor: 4.241