Literature DB >> 35298764

The Potential Crosstalk Between the Brain and Visceral Adipose Tissue in Alzheimer's Development.

Thuy Trang Nguyen1, John Hulme2, Tuong Kha Vo3,4, Giau Van Vo5,6,7.   

Abstract

The bidirectional communication between the brain and peripheral organs have been widely documented, but the impact of visceral adipose tissue (VAT) dysfunction and its relation to structural and functional brain changes have yet to be fully elucidated. This review initially examines the clinical evidence supporting associations between the brain and VAT before visiting the roles of the autonomic nervous system, fat and glucose metabolism, neuroinflammation, and metabolites. Finally, the possible effects and potential mechanisms of the brain-VAT axis on the pathogenesis of Alzheimer's disease are discussed, providing new insights regarding future prevention and therapeutic strategies.
© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

Entities:  

Keywords:  Alzheimer’s disease; Brain; Crosstalk; VAT; Visceral adipose tissue

Mesh：

Year:  2022        PMID： 35298764     DOI： 10.1007/s11064-022-03569-1

Source DB:  PubMed          Journal:  Neurochem Res        ISSN： 0364-3190            Impact factor:   3.996


  95 in total

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Journal:  Nature       Date:  2008-04-09       Impact factor: 49.962

9.  Effect of age, sex, and sites on the cellularity of the adipose tissue in mice and rats rendered obese by a high-fat diet.

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Journal:  J Clin Invest       Date:  1972-11       Impact factor: 14.808

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