Literature DB >> 27788513

Validation of an Efficient Screening Tool to Identify Low-Income Women at High Risk for Hereditary Breast Cancer.

Susan L Stewart1, Celia P Kaplan, Robin Lee, Galen Joseph, Leah Karliner, Jennifer Livaudais-Toman, Rena J Pasick.   

Abstract

BACKGROUND/AIMS: We compared the 6-Point Scale, a screening tool to identify low-income women for referral to genetic counseling, with genetic counselors' (GCs') recommendation and the Referral Screening Tool (RST).
METHODS: RST and 6-Point Scale scores were computed for 2 samples: (1) S1, public hospital mammography clinic patients in 2006-2010 (n = 744), classified by GCs as high risk (meriting referral to counseling) or not high risk, and (2) S2, primary care patients enrolled in an education intervention study in 2011-2012 (n = 1,425). Sensitivity, specificity, and area under the ROC curve (AUROC) were computed for the 6-Point Scale score versus GC and RST classification as high risk.
RESULTS: The 6-Point Scale had low sensitivity (0.27, 95% confidence interval [CI] 0.21-0.34) but high specificity (0.97, 95% CI 0.95-0.99) and AUROC (0.85, 95% CI 0.81-0.90) versus GC classification, and high sensitivity (S1: 0.90, 95% CI 0.79-1.00; S2: 0.94, 95% CI 0.87-0.97), specificity (S1: 0.95, 95% CI 0.93-0.97; S2: 0.94, 95% CI 0.93-0.96), and AUROC (S1: 0.98, 95% CI 0.96-0.99; S2: 0.98, 95% CI 0.98-0.99) versus the RST.
CONCLUSION: The 6-Point Scale compared favorably with the RST, a validated instrument, and is potentially useful as a simple tool for administration in a safety net setting, requiring minimal time investment by primary care physicians and their staff and no financial investment in tablet computers or software.
© 2016 S. Karger AG, Basel.

Entities:  

Mesh:

Year:  2016        PMID: 27788513      PMCID: PMC5215008          DOI: 10.1159/000452095

Source DB:  PubMed          Journal:  Public Health Genomics        ISSN: 1662-4246            Impact factor:   2.000


  27 in total

1.  A randomized, controlled trial to increase discussion of breast cancer in primary care.

Authors:  Celia P Kaplan; Jennifer Livaudais-Toman; Jeffrey A Tice; Karla Kerlikowske; Steven E Gregorich; Eliseo J Pérez-Stable; Rena J Pasick; Alice Chen; Jessica Quinn; Leah S Karliner
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2014-04-24       Impact factor: 4.254

2.  A preliminary validation of a family history assessment form to select women at risk for breast or ovarian cancer for referral to a genetics center.

Authors:  C A Gilpin; N Carson; A G Hunter
Journal:  Clin Genet       Date:  2000-10       Impact factor: 4.438

3.  Perceived cancer risk: why is it lower among nonwhites than whites?

Authors:  Heather Orom; Marc T Kiviniemi; Willie Underwood; Levi Ross; Vickie L Shavers
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2010-02-16       Impact factor: 4.254

4.  Primary care physician management, referral, and relations with specialists concerning patients at risk for cancer due to family history.

Authors:  M E Wood; B S Flynn; A Stockdale
Journal:  Public Health Genomics       Date:  2013-01-17       Impact factor: 2.000

5.  Risk assessment, genetic counseling, and genetic testing for BRCA-related cancer in women: U.S. Preventive Services Task Force recommendation statement.

Authors:  Virginia A Moyer
Journal:  Ann Intern Med       Date:  2014-02-18       Impact factor: 25.391

Review 6.  Hereditary breast cancer: new genetic developments, new therapeutic avenues.

Authors:  Philippe M Campeau; William D Foulkes; Marc D Tischkowitz
Journal:  Hum Genet       Date:  2008-06-25       Impact factor: 4.132

7.  Factors associated with annual-interval mammography for women in their 40s.

Authors:  Jennifer M Gierisch; Suzanne C O'Neill; Barbara K Rimer; Jessica T DeFrank; J Michael Bowling; Celette Sugg Skinner
Journal:  Cancer Epidemiol       Date:  2009-05-29       Impact factor: 2.984

8.  Eligibility criteria in private and public coverage policies for BRCA genetic testing and genetic counseling.

Authors:  Grace Wang; Mary S Beattie; Ninez A Ponce; Kathryn A Phillips
Journal:  Genet Med       Date:  2011-12       Impact factor: 8.822

9.  Population-based study of the prevalence of family history of cancer: implications for cancer screening and prevention.

Authors:  Scott D Ramsey; Paula Yoon; Ramal Moonesinghe; Muin J Khoury
Journal:  Genet Med       Date:  2006-09       Impact factor: 8.822

10.  Evaluation of a breast/ovarian cancer genetics referral screening tool in a mammography population.

Authors:  Cecelia A Bellcross; Amy A Lemke; Laura S Pape; Angela L Tess; Lorraine T Meisner
Journal:  Genet Med       Date:  2009-11       Impact factor: 8.822

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  8 in total

1.  Mental Illness and BRCA1/2 Genetic Testing Intention Among Multiethnic Women Undergoing Screening Mammography.

Authors:  Tarsha Jones; Katherine Freeman; Marra Ackerman; Meghna S Trivedi; Thomas Silverman; Peter Shapiro; Rita Kukafka; Katherine D Crew
Journal:  Oncol Nurs Forum       Date:  2020-01-01       Impact factor: 2.172

2.  Increased ease of access to genetic counseling for low-income women with breast cancer using a point of care screening tool.

Authors:  Smita K Rao; Kimberly A Thomas; Rajbir Singh; Eden Biltibo; Philip E Lammers; Georgia L Wiesner
Journal:  J Community Genet       Date:  2021-01-03

3.  Automatic Genetic Risk Assessment Calculation Using Breast Cancer Family History Data from the EHR compared to Self-Report.

Authors:  Margaret Sin; Julia E McGuinness; Meghna S Trivedi; Alejandro Vanegas; Thomas B Silverman; Katherine D Crew; Rita Kukafka
Journal:  AMIA Annu Symp Proc       Date:  2018-12-05

4.  Understanding Factors Associated with Uptake of BRCA1/2 Genetic Testing among Orthodox Jewish Women in the USA Using a Mixed-Methods Approach.

Authors:  Meghna S Trivedi; Hilary Colbeth; Haeseung Yi; Alejandro Vanegas; Rebecca Starck; Wendy K Chung; Paul S Appelbaum; Rita Kukafka; Isaac Schechter; Katherine D Crew
Journal:  Public Health Genomics       Date:  2019-06-04       Impact factor: 2.000

5.  Uptake of genetic testing for germline BRCA1/2 pathogenic variants in a predominantly Hispanic population.

Authors:  Julia E McGuinness; Meghna S Trivedi; Thomas Silverman; Awilda Marte; Jennie Mata; Rita Kukafka; Katherine D Crew
Journal:  Cancer Genet       Date:  2019-04-24

6.  Insights into BRCA1/2 Genetic Counseling from Ethnically Diverse Latina Breast Cancer Survivors.

Authors:  Neha Rajpal; Juliana Muñoz; Beth N Peshkin; Kristi D Graves
Journal:  J Genet Couns       Date:  2017-04-04       Impact factor: 2.537

7.  Blending Insights from Implementation Science and the Social Sciences to Mitigate Inequities in Screening for Hereditary Cancer Syndromes.

Authors:  Laura Senier; Colleen M McBride; Alex T Ramsey; Vence L Bonham; David A Chambers
Journal:  Int J Environ Res Public Health       Date:  2019-10-15       Impact factor: 3.390

8.  Research to reduce inequities in cancer risk services: Insights for remote genetic counseling in a pandemic and beyond.

Authors:  Robin Lee; Miya Frick; Galen Joseph; Claudia Guerra; Susan Stewart; Celia Kaplan; Niharika Dixit; Janice Y Tsoh; Selena Flores; Rena J Pasick
Journal:  J Genet Couns       Date:  2021-10-23       Impact factor: 2.537

  8 in total

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