| Literature DB >> 2778448 |
Y H Hui1, J K Rupprecht, Y M Liu, J E Anderson, D L Smith, C J Chang, J L McLaughlin.
Abstract
Screening of crude extracts of the bark of Annona bullata showed cytotoxic and pesticidal activities. By monitoring with brine-shrimp lethality, two novel, extremely potent acetogenins, bullatacin [1] and bullatacinone [2], were isolated. Spectral and chemical methods identified bullatacin as a diastereomer of asimicin. Bullatacinone represents bullatacin with the lactone cleaved and reformed at the 4-OH. Compounds 1 and 2 show selective cytotoxicities in human tumor cell lines, and certain susceptible cells give ED50 values as low as 10(-12)-10(-15) micrograms/ml. Bullatacin was pesticidal at concentrations as low as 1 ppm, but bullatacinone lacked pesticidal activities. The known compounds liriodenine and (-)-kaur-16-en-19-oic acid were also isolated and were lethal to brine shrimp but were not significantly cytotoxic.Entities:
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Year: 1989 PMID： 2778448 DOI： 10.1021/np50063a002
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050