Literature DB >> 2362910

16 alpha-hydroxy-(-)-kauranoic acid: a selectively cytotoxic diterpene from Annona bullata.

Y H Hui1, C J Chang, D L Smith, J L McLaughlin.   

Abstract

Using brine shrimp lethality to direct fractionation, extracts of the bark of Annona bullata Rich. (Annonaceae) have yielded 16 alpha-hydroxy-(-)-kauranoic acid as a bioactive plant constituent. This previously known diterpene showed significant (ED50 8.25 x 10(-2) micrograms/ml) and selective cytotoxicity against A-549 (lung) cells in our panel of human tumor cells.

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Year:  1990        PMID： 2362910     DOI： 10.1023/a:1015819422479

Source DB:  PubMed          Journal:  Pharm Res        ISSN： 0724-8741            Impact factor:   4.200


  3 in total

1.  Brine shrimp: a convenient general bioassay for active plant constituents.

Authors:  B N Meyer; N R Ferrigni; J E Putnam; L B Jacobsen; D E Nichols; J L McLaughlin
Journal:  Planta Med       Date:  1982-05       Impact factor: 3.352

2.  Modification and evaluation of the potato disc assay and antitumor screening of euphorbiaceae seeds.

Authors:  N R Ferrigni; J E Putnam; B Anderson; L B Jacobsen; D E Nichols; D S Moore; J L McLaughlin; R G Powell; C R Smith
Journal:  J Nat Prod       Date:  1982 Nov-Dec       Impact factor: 4.050

3.  Bullatacin and bullatacinone: two highly potent bioactive acetogenins from Annona bullata.

Authors:  Y H Hui; J K Rupprecht; Y M Liu; J E Anderson; D L Smith; C J Chang; J L McLaughlin
Journal:  J Nat Prod       Date:  1989 May-Jun       Impact factor: 4.050
  3 in total
  1 in total

Review 1.  Medicinal chemistry and pharmacology of genus Tripterygium (Celastraceae).

Authors:  Anita M Brinker; Jun Ma; Peter E Lipsky; Ilya Raskin
Journal:  Phytochemistry       Date:  2007-01-23       Impact factor: 4.072
  1 in total

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