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Literature DB >> 22136523

Antiproliferative acetogenins from a Uvaria sp. from the Madagascar dry forest.

Yumin Dai¹, Liva Harinantenaina, Peggy J Brodie, Martin W Callmander, Richard Randrianaivo, Stephan Rakotonandrasana, Etienne Rakotobe, Vincent E Rasamison, Yongchun Shen, Karen TenDyke, Edward M Suh, David G I Kingston.

Abstract

Investigation of the endemic Madagascan plant Uvaria sp. for antiproliferative activity against the A2780 ovarian cancer cell line led to the isolation of two new acetogenins. The structures of these two compounds were elucidated on the basis of analysis of their 1D and 2D NMR spectra, circular dichroism, and mass spectrometric data, together with chemical modification. The two acetogenins display weak antiproliferative activity against the A2780 ovarian cancer, the A2058 melanoma, and the H522 lung cancer cell lines.

Entities: CellLine Chemical Disease Gene Species

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Year: 2011 PMID： 22136523 PMCID： PMC3243105 DOI： 10.1021/np200697j

Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050

24 in total

1. New annonaceous acetogenins from Rollinia mucosa.

Authors: C C Liaw; F R Chang; Y Y Chen; H F Chiu; M J Wu; Y C Wu
Journal: J Nat Prod Date: 1999-12 Impact factor: 4.050

Review 2. Novel constituents of Uvaria species.

Authors: V S Parmar; O D Tyagi; A Malhotra; S K Singh; K S Bisht; R Jain
Journal: Nat Prod Rep Date: 1994-04 Impact factor: 13.423

3. Novel cytotoxic annonaceous acetogenins from Annona muricata.

Authors: F R Chang; Y C Wu
Journal: J Nat Prod Date: 2001-07 Impact factor: 4.050

4. Structural revisions of some non-adjacent bis-tetrahydrofuran annonaceous acetogenins.

Authors: X P Fang; Z M Gu; M J Rieser; Y H Hui; J L McLaughlin; M Nonfon; F Lieb; H F Moeschler; D Wendisch
Journal: J Nat Prod Date: 1993-07 Impact factor: 4.050

5. Antiplasmodial and antiproliferative pseudoguaianolides of Athroisma proteiforme from the Madagascar Dry Forest.

Authors: Ende Pan; Alexander P Gorka; John N Alumasa; Carla Slebodnick; Liva Harinantenaina; Peggy J Brodie; Paul D Roepe; Richard Randrianaivo; Chris Birkinshaw; David G I Kingston
Journal: J Nat Prod Date: 2011-10-13 Impact factor: 4.050

6. In vitro antitumor SAR of threo/cis/threo/cis/erythro bis-THF acetogenins: correlations with their inhibition of mitochondrial Complex I.

Authors: Inmaculada Royo; Nuria DePedro; Ernesto Estornell; Diego Cortes; Fernando Peláez; José R Tormo
Journal: Oncol Res Date: 2003 Impact factor: 5.574

7. New chemical constituents of Euphorbia quinquecostata and absolute configuration assignment by a convenient Mosher ester procedure carried out in NMR tubes.

Authors: Bao-Ning Su; Eun Jung Park; Zakaria H Mbwambo; Bernard D Santarsiero; Andrew D Mesecar; Harry H S Fong; John M Pezzuto; A Douglas Kinghorn
Journal: J Nat Prod Date: 2002-09 Impact factor: 4.050

Review 3. Modulation of inflammatory pathways, medicinal uses and toxicities of Uvaria species: potential role in the prevention and treatment of inflammation.

Authors: Juriyati Jalil; Ali Attiq; Chiew Chia Hui; Lui Jin Yao; Nurul Aimi Zakaria
Journal: Inflammopharmacology Date: 2020-07-02 Impact factor: 4.473

3 in total

Antiproliferative acetogenins from a Uvaria sp. from the Madagascar dry forest.

1. New annonaceous acetogenins from Rollinia mucosa.

Review 2. Novel constituents of Uvaria species.

3. Novel cytotoxic annonaceous acetogenins from Annona muricata.

4. Structural revisions of some non-adjacent bis-tetrahydrofuran annonaceous acetogenins.

5. Antiplasmodial and antiproliferative pseudoguaianolides of Athroisma proteiforme from the Madagascar Dry Forest.

6. In vitro antitumor SAR of threo/cis/threo/cis/erythro bis-THF acetogenins: correlations with their inhibition of mitochondrial Complex I.

7. New chemical constituents of Euphorbia quinquecostata and absolute configuration assignment by a convenient Mosher ester procedure carried out in NMR tubes.

8. Bullatacin and bullatacinone: two highly potent bioactive acetogenins from Annona bullata.

9. Essential structural features of acetogenins: role of hydroxy groups adjacent to the bis-THF rings.

10. Selective action of acetogenin mitochondrial complex I inhibitors.

1. Antiproliferative Homoisoflavonoids and Bufatrienolides from Urginea depressa.

2. Two antiproliferative saponins of Tarenna grevei from the Madagascar dry forest [1].

Review 3. Modulation of inflammatory pathways, medicinal uses and toxicities of Uvaria species: potential role in the prevention and treatment of inflammation.