Literature DB >> 2347408

Gigantecin: a novel antimitotic and cytotoxic acetogenin, with nonadjacent tetrahydrofuran rings, from Goniothalamus giganteus (Annonaceae).

A Alkofahi1, J K Rupprecht, Y M Liu, C J Chang, D L Smith, J L McLaughlin.   

Abstract

Gigantecin (I), a novel tetrahydroxy-di-tetrahydrofuran fatty acid gamma-lactone (acetogenin), was isolated from an ethanolic extract of the stem bark of Goniothalamus giganteus Hook. f., Thomas (Annonaceae), by means of activity-directed fractionation (brine shrimp lethality test). This new compound is extremely cytotoxic to human tumor cells, inhibits crown gall tumors on potato discs, and is active in an assay designed to detect antimitotic agents (9 ASK).

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Year:  1990        PMID： 2347408     DOI： 10.1007/bf01954260

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  4 in total

1.  Brine shrimp: a convenient general bioassay for active plant constituents.

Authors:  B N Meyer; N R Ferrigni; J E Putnam; L B Jacobsen; D E Nichols; J L McLaughlin
Journal:  Planta Med       Date:  1982-05       Impact factor: 3.352

2.  Modification and evaluation of the potato disc assay and antitumor screening of euphorbiaceae seeds.

Authors:  N R Ferrigni; J E Putnam; B Anderson; L B Jacobsen; D E Nichols; D S Moore; J L McLaughlin; R G Powell; C R Smith
Journal:  J Nat Prod       Date:  1982 Nov-Dec       Impact factor: 4.050

3.  Goniothalamicin and annonacin: bioactive acetogenins from Goniothalamus giganteus (Annonaceae).

Authors:  A Alkofahi; J K Rupprecht; D L Smith; C J Chang; J L McLaughlin
Journal:  Experientia       Date:  1988-01-15

4.  Bullatacin and bullatacinone: two highly potent bioactive acetogenins from Annona bullata.

Authors:  Y H Hui; J K Rupprecht; Y M Liu; J E Anderson; D L Smith; C J Chang; J L McLaughlin
Journal:  J Nat Prod       Date:  1989 May-Jun       Impact factor: 4.050
  4 in total
  3 in total

1.  Goniothalamus species: a source of drugs for the treatment of cancers and bacterial infections?

Authors:  Christophe Wiart
Journal:  Evid Based Complement Alternat Med       Date:  2007-09       Impact factor: 2.629

2.  Total synthesis of annonaceous acetogenins belonging to the non-adjacent bis-THF and non-adjacent THF-THP sub-classes.

Authors:  Ian B Spurr; Richard C D Brown
Journal:  Molecules       Date:  2010-01-21       Impact factor: 4.411

3.  Recent progress on the total synthesis of acetogenins from Annonaceae.

Authors:  Nianguang Li; Zhihao Shi; Yuping Tang; Jianwei Chen; Xiang Li
Journal:  Beilstein J Org Chem       Date:  2008-12-05       Impact factor: 2.883
  3 in total

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