Mohammad Eghtedari1, Jingfei Ma2, Patricia Fox3, Inanc Guvenc4, Wei T Yang5, Basak E Dogan6. 1. Department of Radiology, University of California San Diego, San Diego, CA, USA. 2. Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. 3. Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. 4. Department of Diagnostic Radiology, Medical Park Hospital, Ankara, Turkey. 5. Department of Diagnostic Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. 6. Department of Diagnostic Radiology, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
Abstract
BACKGROUND: To evaluate the effect of b value or the magnetic field strength (B0) on the sensitivity and specificity of quantitative breast diffusion-weighted imaging (DWI). METHODS: A total of 126 patients underwent clinical breast MRI that included pre-contrast DWI imaging using b values of both 1,000 and 1,500 s/mm2 at either 1.5 T (n=86) or 3.0 T (n=40). Quantitative apparent diffusion coefficients (ADC) were measured and compared for 18 benign, 33 malignant lesions, and 126 normal breast tissues. Optimal ADCmean threshold for differentiating benign and malignant lesions was estimated and the effect of b values and B0 were examined using a generalized estimating equations (GEE) model. RESULTS: The optimal ADCmean threshold was 1.235×10-3 mm2/s for b value of 1,000 and 0.934×10-3 mm2/s for b value of 1,500. Using these thresholds, the sensitivities and specificities were 96% and 89% (b value =1,000, B0 =1.5 T), 89% and 98% (b value =1,000, B0 =3.0 T), 88% and 96% (b value =1,500, B0 =1.5 T), and 67% and 100% (b value =1,500, B0 =3.0 T). No significant difference was found between different B0 (P=0.26) or b values (P=0.28). CONCLUSIONS: Better sensitivity is achieved with DWI of b value =1,000 than with b value =1,500. However, b value and B0 do not significantly impact diagnostic performance of DWI when using appropriate thresholds.
BACKGROUND: To evaluate the effect of b value or the magnetic field strength (B0) on the sensitivity and specificity of quantitative breast diffusion-weighted imaging (DWI). METHODS: A total of 126 patients underwent clinical breast MRI that included pre-contrast DWI imaging using b values of both 1,000 and 1,500 s/mm2 at either 1.5 T (n=86) or 3.0 T (n=40). Quantitative apparent diffusion coefficients (ADC) were measured and compared for 18 benign, 33 malignant lesions, and 126 normal breast tissues. Optimal ADCmean threshold for differentiating benign and malignant lesions was estimated and the effect of b values and B0 were examined using a generalized estimating equations (GEE) model. RESULTS: The optimal ADCmean threshold was 1.235×10-3 mm2/s for b value of 1,000 and 0.934×10-3 mm2/s for b value of 1,500. Using these thresholds, the sensitivities and specificities were 96% and 89% (b value =1,000, B0 =1.5 T), 89% and 98% (b value =1,000, B0 =3.0 T), 88% and 96% (b value =1,500, B0 =1.5 T), and 67% and 100% (b value =1,500, B0 =3.0 T). No significant difference was found between different B0 (P=0.26) or b values (P=0.28). CONCLUSIONS: Better sensitivity is achieved with DWI of b value =1,000 than with b value =1,500. However, b value and B0 do not significantly impact diagnostic performance of DWI when using appropriate thresholds.
Entities:
Keywords:
Breast MRI; b value; benign and malignant lesions; diffusion-weighted imaging (DWI); magnetic field strength
Authors: Wolfgang Bogner; Stephan Gruber; Katja Pinker; Günther Grabner; Andreas Stadlbauer; Michael Weber; Ewald Moser; Thomas H Helbich; Siegfried Trattnig Journal: Radiology Date: 2009-07-31 Impact factor: 11.105
Authors: Elisabeth Sartoretti; Sabine Sartoretti-Schefer; Luuk van Smoorenburg; Barbara Eichenberger; Árpád Schwenk; David Czell; Alex Alfieri; Andreas Gutzeit; Manoj Mannil; Christoph A Binkert; Michael Wyss; Thomas Sartoretti Journal: Eur J Radiol Open Date: 2021-09-22