PURPOSE: We evaluated the usefulness of quantitative and visual assessment of diffusion-weighted imaging (DWI) of breast tumors to distinguish malignant from benign tumors. MATERIALS AND METHODS: The DWI findings of 106 breast lesions (15 benign, 91 malignant) were retrospectively analyzed. The mean apparent diffusion coefficient (ADC) value for each lesion was calculated using b values of 250, 500, 750, and 1000 s/mm(2) as a quantitative assessment. We visually evaluated the signal intensity of each breast lesion on the basis of a spinal signal intensity in DWI (b = 1000 s/mm(2)) and compared the mean ADC values using a threshold mean ADC +1.65 × standard deviation (SD) for malignant and benign breast lesions. Obviously strong signal intensity of the lesion relative to that of the spinal cord on DWI signifies malignancy. RESULTS: The mean ADC value for benign lesions (1.50 ± 0.38 × 10(-3) mm(2)/s) was significantly higher than that for malignant lesions (0.98 ± 0.19 × 10(-3) mm(2)/s), with 94.5% sensitivity, 80% specificity, and 92.5% accuracy. Sensitivity for visual assessment was 91.5%, specificity was 33.3%, and total accuracy was 82.5%. CONCLUSION: ADC values, but not visual assessment, may be useful for differentiating benign and malignant breast tumors.
PURPOSE: We evaluated the usefulness of quantitative and visual assessment of diffusion-weighted imaging (DWI) of breast tumors to distinguish malignant from benign tumors. MATERIALS AND METHODS: The DWI findings of 106 breast lesions (15 benign, 91 malignant) were retrospectively analyzed. The mean apparent diffusion coefficient (ADC) value for each lesion was calculated using b values of 250, 500, 750, and 1000 s/mm(2) as a quantitative assessment. We visually evaluated the signal intensity of each breast lesion on the basis of a spinal signal intensity in DWI (b = 1000 s/mm(2)) and compared the mean ADC values using a threshold mean ADC +1.65 × standard deviation (SD) for malignant and benign breast lesions. Obviously strong signal intensity of the lesion relative to that of the spinal cord on DWI signifies malignancy. RESULTS: The mean ADC value for benign lesions (1.50 ± 0.38 × 10(-3) mm(2)/s) was significantly higher than that for malignant lesions (0.98 ± 0.19 × 10(-3) mm(2)/s), with 94.5% sensitivity, 80% specificity, and 92.5% accuracy. Sensitivity for visual assessment was 91.5%, specificity was 33.3%, and total accuracy was 82.5%. CONCLUSION: ADC values, but not visual assessment, may be useful for differentiating benign and malignant breast tumors.
Authors: T Sugahara; Y Korogi; M Kochi; I Ikushima; Y Shigematu; T Hirai; T Okuda; L Liang; Y Ge; Y Komohara; Y Ushio; M Takahashi Journal: J Magn Reson Imaging Date: 1999-01 Impact factor: 4.813
Authors: Pascal A T Baltzer; Matthias Benndorf; Matthias Dietzel; Mieczyslaw Gajda; Oumar Camara; Werner A Kaiser Journal: Eur Radiol Date: 2009-11-20 Impact factor: 5.315
Authors: P Mürtz; M Tsesarskiy; A Kowal; F Träber; J Gieseke; W A Willinek; C C Leutner; A Schmiedel; H H Schild Journal: Eur Radiol Date: 2014-06-05 Impact factor: 5.315
Authors: Jason Ostenson; Akshat C Pujara; Artem Mikheev; Linda Moy; Sungheon G Kim; Amy N Melsaether; Komal Jhaveri; Sylvia Adams; David Faul; Christopher Glielmi; Christian Geppert; Thorsten Feiweier; Kimberly Jackson; Gene Y Cho; Fernando E Boada; Eric E Sigmund Journal: Magn Reson Med Date: 2016-10-25 Impact factor: 4.668