Literature DB >> 27704392

Ancestry Testing and the Practice of Genetic Counseling.

Brianne E Kirkpatrick1, Misha D Rashkin2.   

Abstract

Ancestry testing is a home DNA test with many dimensions; in some cases, the implications and outcomes of testing cross over into the health sphere. Common reasons for seeking ancestry testing include determining an estimate of customer's ethnic background, identifying genetic relatives, and securing a raw DNA data file that can be used for other purposes. As the ancestry test marketplace continues to grow, and third-party vendors empower the general public to analyze their own genetic material, the role of the genetic counselor is likely to evolve dramatically. Roles of the genetic counselor may include assisting clients with the interpretation of and adaptation to these results, as well as advising the companies involved in this sector on the ethical, legal, and social issues associated with testing. This paper reviews the history, fundamentals, intended uses, and unintended consequences of ancestry genetic testing. It also discusses the types of information in an ancestry testing result, situations that might involve a clinical genetic counselor, and the benefits, limitations, and functions that ancestry genetic testing can play in a clinical genetics setting.

Keywords:  Ancestry; Databases; Direct to consumer; Genetic counseling; Personal genomics; Third-party tool

Mesh:

Year:  2016        PMID: 27704392     DOI: 10.1007/s10897-016-0014-2

Source DB:  PubMed          Journal:  J Genet Couns        ISSN: 1059-7700            Impact factor:   2.537


  56 in total

1.  The prospect of genome-guided preventive medicine: a need and opportunity for genetic counselors.

Authors:  Julianne M O'Daniel
Journal:  J Genet Couns       Date:  2010-05-04       Impact factor: 2.537

2.  Direct-to-consumer personal genomic testing: a case study and practical recommendations for “genomic counseling”.

Authors:  Amy C Sturm; Kandamurugu Manickam
Journal:  J Genet Couns       Date:  2012-06       Impact factor: 2.537

3.  Analysis of mitochondrial genome diversity identifies new and ancient maternal lineages in Cambodian aborigines.

Authors:  Xiaoming Zhang; Xuebin Qi; Zhaohui Yang; Bun Serey; Tuot Sovannary; Long Bunnath; Hong Seang Aun; Ham Samnom; Hui Zhang; Qiang Lin; Mannis van Oven; Hong Shi; Bing Su
Journal:  Nat Commun       Date:  2013       Impact factor: 14.919

4.  The familiality of pelvic organ prolapse in the Utah Population Database.

Authors:  Peggy A Norton; Kristina Allen-Brady; Lisa A Cannon-Albright
Journal:  Int Urogynecol J       Date:  2012-08-14       Impact factor: 2.894

5.  ACOG Committee Opinion No. 409: Direct-to-consumer marketing of genetic testing.

Authors: 
Journal:  Obstet Gynecol       Date:  2008-06       Impact factor: 7.661

6.  Molecular anthropology in the genomic era.

Authors:  Giovanni Destro-Bisol; Mark A Jobling; Jorge Rocha; John Novembre; Martin B Richards; Connie Mulligan; Chiara Batini; Franz Manni
Journal:  J Anthropol Sci       Date:  2010

7.  Creation of a national resource with linked genealogy and phenotypic data: the Veterans Genealogy Project.

Authors:  Lisa A Cannon-Albright; Sue Dintelman; Tim Maness; Steve Backus; Alun Thomas; Laurence J Meyer
Journal:  Genet Med       Date:  2013-01-17       Impact factor: 8.822

8.  Genome-wide genotype and sequence-based reconstruction of the 140,000 year history of modern human ancestry.

Authors:  Daniel Shriner; Fasil Tekola-Ayele; Adebowale Adeyemo; Charles N Rotimi
Journal:  Sci Rep       Date:  2014-08-13       Impact factor: 4.379

9.  A panel of ancestry informative markers for the complex five-way admixed South African coloured population.

Authors:  Michelle Daya; Lize van der Merwe; Ushma Galal; Marlo Möller; Muneeb Salie; Emile R Chimusa; Joshua M Galanter; Paul D van Helden; Brenna M Henn; Chris R Gignoux; Eileen Hoal
Journal:  PLoS One       Date:  2013-12-20       Impact factor: 3.240

10.  An old problem in a new age: Revisiting the clinical dilemma of misattributed paternity.

Authors:  Laura Hercher; Leila Jamal
Journal:  Appl Transl Genom       Date:  2016-02-01
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  10 in total

1.  Third-Party Genetic Interpretation Tools: A Mixed-Methods Study of Consumer Motivation and Behavior.

Authors:  Sarah C Nelson; Deborah J Bowen; Stephanie M Fullerton
Journal:  Am J Hum Genet       Date:  2019-06-13       Impact factor: 11.025

2.  Impacts of personal DNA ancestry testing.

Authors:  Caryn Kseniya Rubanovich; Riley Taitingfong; Cynthia Triplett; Ondrej Libiger; Nicholas J Schork; Jennifer K Wagner; Cinnamon S Bloss
Journal:  J Community Genet       Date:  2020-08-13

3.  Paternity testing under the cloak of recreational genetics.

Authors:  Nathalie Moray; Katherina E Pink; Pascal Borry; Maarten Hd Larmuseau
Journal:  Eur J Hum Genet       Date:  2017-03-08       Impact factor: 4.246

4.  "Bridge to the Literature"? Third-Party Genetic Interpretation Tools and the Views of Tool Developers.

Authors:  Sarah C Nelson; Stephanie M Fullerton
Journal:  J Genet Couns       Date:  2018-02-07       Impact factor: 2.537

5.  Family secrets: Experiences and outcomes of participating in direct-to-consumer genetic relative-finder services.

Authors:  Christi J Guerrini; Jill O Robinson; Cinnamon C Bloss; Whitney Bash Brooks; Stephanie M Fullerton; Brianne Kirkpatrick; Sandra Soo-Jin Lee; Mary Majumder; Stacey Pereira; Olivia Schuman; Amy L McGuire
Journal:  Am J Hum Genet       Date:  2022-02-24       Impact factor: 11.043

6.  Communicating 5-Year Risk of Alzheimer's Disease Dementia: Development and Evaluation of Materials that Incorporate Multiple Genetic and Biomarker Research Results.

Authors:  Jessica Mozersky; Sarah Hartz; Erin Linnenbringer; Lillie Levin; Marissa Streitz; Kristin Stock; Krista Moulder; John C Morris
Journal:  J Alzheimers Dis       Date:  2021       Impact factor: 4.472

7.  Regulation of Internet-based Genetic Testing: Challenges for Australia and Other Jurisdictions.

Authors:  Jane Tiller; Paul Lacaze
Journal:  Front Public Health       Date:  2018-02-15

Review 8.  Mitochondria in Mycobacterium Infection: From the Immune System to Mitochondrial Haplogroups.

Authors:  Felipe Gouvea de Souza; Giovanna C Cavalcante
Journal:  Int J Mol Sci       Date:  2022-08-23       Impact factor: 6.208

9.  Consumer use and response to online third-party raw DNA interpretation services.

Authors:  Catharine Wang; Tiernan J Cahill; Andrew Parlato; Blake Wertz; Qiankun Zhong; Tricia Norkunas Cunningham; James J Cummings
Journal:  Mol Genet Genomic Med       Date:  2017-11-02       Impact factor: 2.183

10.  Australians' views and experience of personal genomic testing: survey findings from the Genioz study.

Authors:  Jacqueline Savard; Chriselle Hickerton; Rigan Tytherleigh; Bronwyn Terrill; Erin Turbitt; Ainsley J Newson; Brenda Wilson; Kathleen Gray; Clara Gaff; Anna Middleton; Elaine Stackpoole; Sylvia A Metcalfe
Journal:  Eur J Hum Genet       Date:  2019-01-21       Impact factor: 4.246

  10 in total

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