OBJECTIVE: The pathophysiology of obsessive-compulsive disorder (OCD) involves increased activity in corticostriatal circuits connecting the anterior cingulate cortex with other brain regions. The error-related negativity (ERN) is a negative deflection in the event-related potential after an incorrect response that is believed to reflect anterior cingulate cortex activity. This study examined the relation of the ERN to OCD symptom dimensions and other childhood symptom dimensions. METHOD: The ERN, correct response negativity, and accuracy were measured during a flanker task to assess performance monitoring in 80 youth with a lifetime diagnosis of OCD and 80 matched healthy comparison participants ranging from 8 to 18 years old. The relation of the ERN to OCD symptom dimension scores and Child Behavior Checklist Syndrome Scale scores was examined in multiple linear regression analyses. RESULTS: Accuracy was significantly decreased and ERN amplitude was significantly increased in patients compared with controls. ERN amplitude in patients was significantly correlated with accuracy, but not with OCD symptom dimensions, severity, comorbidity, or treatment. In a multiple linear regression analysis using age, accuracy, OCD, and Child Behavior Checklist Syndrome Scale scores as predictors of ERN amplitude, the ERN had significant associations only with Withdrawn/Depressed Scale scores and accuracy. CONCLUSION: An enlarged ERN is a neural correlate of pediatric OCD that is independent of OCD symptom expression and severity. The finding of lower accuracy in pediatric cases requires replication. The relation between an enhanced ERN and withdrawn/depressed behaviors warrants further research in youth with OCD and other internalizing disorders.
OBJECTIVE: The pathophysiology of obsessive-compulsive disorder (OCD) involves increased activity in corticostriatal circuits connecting the anterior cingulate cortex with other brain regions. The error-related negativity (ERN) is a negative deflection in the event-related potential after an incorrect response that is believed to reflect anterior cingulate cortex activity. This study examined the relation of the ERN to OCD symptom dimensions and other childhood symptom dimensions. METHOD: The ERN, correct response negativity, and accuracy were measured during a flanker task to assess performance monitoring in 80 youth with a lifetime diagnosis of OCD and 80 matched healthy comparison participants ranging from 8 to 18 years old. The relation of the ERN to OCD symptom dimension scores and Child Behavior Checklist Syndrome Scale scores was examined in multiple linear regression analyses. RESULTS: Accuracy was significantly decreased and ERN amplitude was significantly increased in patients compared with controls. ERN amplitude in patients was significantly correlated with accuracy, but not with OCD symptom dimensions, severity, comorbidity, or treatment. In a multiple linear regression analysis using age, accuracy, OCD, and Child Behavior Checklist Syndrome Scale scores as predictors of ERN amplitude, the ERN had significant associations only with Withdrawn/Depressed Scale scores and accuracy. CONCLUSION: An enlarged ERN is a neural correlate of pediatric OCD that is independent of OCD symptom expression and severity. The finding of lower accuracy in pediatric cases requires replication. The relation between an enhanced ERN and withdrawn/depressed behaviors warrants further research in youth with OCD and other internalizing disorders.
Authors: Ronald C Kessler; Patricia Berglund; Olga Demler; Robert Jin; Kathleen R Merikangas; Ellen E Walters Journal: Arch Gen Psychiatry Date: 2005-06
Authors: James J Hudziak; Robert R Althoff; Catherine Stanger; C E M van Beijsterveldt; Elliot C Nelson; Gregory L Hanna; Dorret I Boomsma; Richard D Todd Journal: J Child Psychol Psychiatry Date: 2006-02 Impact factor: 8.982
Authors: Gregory L Hanna; Yanni Liu; Yona E Isaacs; Angela M Ayoub; Alice Brosius; Zachary Salander; Paul D Arnold; William J Gehring Journal: Depress Anxiety Date: 2018-05-07 Impact factor: 6.505
Authors: Alexandra R Tabachnick; Emilio A Valadez; Erin N Palmwood; Lindsay Zajac; Robert F Simons; Mary Dozier Journal: Psychophysiology Date: 2018-08-10 Impact factor: 4.016
Authors: Gregory L Hanna; Yanni Liu; Haley E Rough; Mihir Surapaneni; Barbara S Hanna; Paul D Arnold; William J Gehring Journal: Child Psychiatry Hum Dev Date: 2020-10
Authors: Darci T Butcher; Cheryl Cytrynbaum; Andrei L Turinsky; Michelle T Siu; Michal Inbar-Feigenberg; Roberto Mendoza-Londono; David Chitayat; Susan Walker; Jerry Machado; Oana Caluseriu; Lucie Dupuis; Daria Grafodatskaya; William Reardon; Brigitte Gilbert-Dussardier; Alain Verloes; Frederic Bilan; Jeff M Milunsky; Raveen Basran; Blake Papsin; Tracy L Stockley; Stephen W Scherer; Sanaa Choufani; Michael Brudno; Rosanna Weksberg Journal: Am J Hum Genet Date: 2017-05-04 Impact factor: 11.025
Authors: M T Siu; D T Butcher; A L Turinsky; C Cytrynbaum; D J Stavropoulos; S Walker; O Caluseriu; M Carter; Y Lou; R Nicolson; S Georgiades; P Szatmari; E Anagnostou; S W Scherer; S Choufani; M Brudno; R Weksberg Journal: Clin Epigenetics Date: 2019-07-16 Impact factor: 6.551
Authors: Sanaa Choufani; William T Gibson; Andrei L Turinsky; Brian H Y Chung; Tianren Wang; Kopal Garg; Alessandro Vitriolo; Ana S A Cohen; Sharri Cyrus; Sarah Goodman; Eric Chater-Diehl; Jack Brzezinski; Michael Brudno; Luk Ho Ming; Susan M White; Sally Ann Lynch; Carol Clericuzio; I Karen Temple; Frances Flinter; Vivienne McConnell; Tom Cushing; Lynne M Bird; Miranda Splitt; Bronwyn Kerr; Stephen W Scherer; Jerry Machado; Eri Imagawa; Nobuhiko Okamoto; Naomichi Matsumoto; Guiseppe Testa; Maria Iascone; Romano Tenconi; Oana Caluseriu; Roberto Mendoza-Londono; David Chitayat; Cheryl Cytrynbaum; Katrina Tatton-Brown; Rosanna Weksberg Journal: Am J Hum Genet Date: 2020-04-02 Impact factor: 11.025