Gregory L Hanna1, Yanni Liu1, Yona E Isaacs1, Angela M Ayoub1, Alice Brosius2, Zachary Salander3, Paul D Arnold4, William J Gehring2. 1. Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA. 2. Department of Psychology, University of Michigan, Ann Arbor, MI, USA. 3. Department of Psychological and Brain Sciences, University of Massachusetts, Amherst, MA, USA. 4. Department of Psychiatry, University of Calgary, Calgary, CA, USA.
Abstract
BACKGROUND: The error-related negativity (ERN) is a negative deflection in the event-related potential following a mistake that is often increased in patients with obsessive-compulsive disorder (OCD). The relationship of the ERN to comorbid major depressive disorder (MDD) has not been examined in adolescents with OCD. This study compared ERN amplitudes in OCD patients with MDD (OCD + MDD), OCD patients without MDD (OCD - MDD), MDD patients, and healthy controls (HC). METHOD: The ERN, correct response negativity, and accuracy were measured during a flanker task to assess performance monitoring in 53 adolescents with a lifetime diagnosis of OCD, 36 adolescents with a lifetime diagnosis of MDD, and 89 age-matched HC of 13-18 years. Fourteen OCD patients had a history of MDD. RESULTS: ERN amplitude was significantly increased in OCD patients compared to HC and significantly correlated in OCD patients with age at OCD symptom onset, particularly in the OCD - MDD patients. The ERN was significantly enlarged in OCD + MDD patients compared to HC, but not in MDD patients compared to HC. There was a trend for an increased ERN amplitude in OCD - MDD patients compared to HC. OCD patients were significantly less accurate than either MDD patients or HC. CONCLUSIONS: An enlarged ERN is a neural correlate of adolescent OCD that is associated with age at OCD symptom onset. Adolescents with OCD may have impaired cognitive control on a flanker task. Follow-up studies with larger samples may determine whether an enlarged ERN in adolescents with OCD is associated with a higher risk for MDD.
BACKGROUND: The error-related negativity (ERN) is a negative deflection in the event-related potential following a mistake that is often increased in patients with obsessive-compulsive disorder (OCD). The relationship of the ERN to comorbid major depressive disorder (MDD) has not been examined in adolescents with OCD. This study compared ERN amplitudes in OCDpatients with MDD (OCD + MDD), OCDpatients without MDD (OCD - MDD), MDDpatients, and healthy controls (HC). METHOD: The ERN, correct response negativity, and accuracy were measured during a flanker task to assess performance monitoring in 53 adolescents with a lifetime diagnosis of OCD, 36 adolescents with a lifetime diagnosis of MDD, and 89 age-matched HC of 13-18 years. Fourteen OCDpatients had a history of MDD. RESULTS: ERN amplitude was significantly increased in OCDpatients compared to HC and significantly correlated in OCDpatients with age at OCD symptom onset, particularly in the OCD - MDDpatients. The ERN was significantly enlarged in OCD + MDDpatients compared to HC, but not in MDDpatients compared to HC. There was a trend for an increased ERN amplitude in OCD - MDDpatients compared to HC. OCDpatients were significantly less accurate than either MDDpatients or HC. CONCLUSIONS: An enlarged ERN is a neural correlate of adolescent OCD that is associated with age at OCD symptom onset. Adolescents with OCD may have impaired cognitive control on a flanker task. Follow-up studies with larger samples may determine whether an enlarged ERN in adolescents with OCD is associated with a higher risk for MDD.
Authors: Cecile D Ladouceur; John S Slifka; Ronald E Dahl; Boris Birmaher; David A Axelson; Neal D Ryan Journal: Dev Cogn Neurosci Date: 2012-02-08 Impact factor: 6.464
Authors: Emily R Stern; Yanni Liu; William J Gehring; James J Lister; Gang Yin; Jun Zhang; Kate D Fitzgerald; Joseph A Himle; James L Abelson; Stephan F Taylor Journal: Psychophysiology Date: 2010-03-08 Impact factor: 4.016
Authors: Amitai Abramovitch; Jonathan S Abramowitz; Andrew Mittelman; Abigail Stark; Kesley Ramsey; Daniel A Geller Journal: J Child Psychol Psychiatry Date: 2015-04-13 Impact factor: 8.982
Authors: Didier Schrijvers; Ellen R A de Bruijn; Yvonne Maas; Carmen De Grave; Bernard G C Sabbe; Wouter Hulstijn Journal: Cortex Date: 2007-12-23 Impact factor: 4.027
Authors: Gregory L Hanna; Melisa Carrasco; Shannon M Harbin; Jenna K Nienhuis; Christina E LaRosa; Poyu Chen; Kate D Fitzgerald; William J Gehring Journal: J Am Acad Child Adolesc Psychiatry Date: 2012-07-25 Impact factor: 8.829
Authors: Kate D Fitzgerald; Hans S Schroder; Meryl Rueppel; Kristin A Mannella Journal: Cogn Affect Behav Neurosci Date: 2021-12-29 Impact factor: 3.526
Authors: Gregory L Hanna; Yanni Liu; Haley E Rough; Mihir Surapaneni; Barbara S Hanna; Paul D Arnold; William J Gehring Journal: Child Psychiatry Hum Dev Date: 2020-10