Literature DB >> 27652322

A link between TP53 polymorphisms and metabolism.

Che-Pei Kung1, Subhasree Basu1, Maureen E Murphy1.   

Abstract

Besides being a critical tumor suppressor, the TP53 gene also plays a role in metabolism and recent studies in humans have implicated the codon 72 polymorphism of TP53 in this role. Using a humanized knock-in mouse model for these TP53 variants, we show that this polymorphism has a significant impact on the metabolic response to a high-fat diet.

Entities:  

Keywords:  Diabetes; Npc1l1; Tnf; inflammation; lipid metabolism; obesity; p53 polymorphism

Year:  2016        PMID： 27652322      PMCID： PMC4972101          DOI： 10.1080/23723556.2016.1173769

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

1.  Diabetes mellitus: a "thrifty" genotype rendered detrimental by "progress"?

Authors:  J V NEEL
Journal:  Am J Hum Genet       Date:  1962-12       Impact factor: 11.025

Review 2.  Polymorphic variants in the p53 pathway.

Authors:  M E Murphy
Journal:  Cell Death Differ       Date:  2006-06       Impact factor: 15.828

3.  Winter temperature and UV are tightly linked to genetic changes in the p53 tumor suppressor pathway in Eastern Asia.

Authors:  Hong Shi; Si-jie Tan; Hua Zhong; Wenwei Hu; Arnold Levine; Chun-jie Xiao; Yi Peng; Xue-bin Qi; Wei-hua Shou; Run-lin Z Ma; Yi Li; Bing Su; Xin Lu
Journal:  Am J Hum Genet       Date:  2009-04-02       Impact factor: 11.025

4.  The p53 family: guardians of maternal reproduction.

Authors:  Arnold J Levine; Richard Tomasini; Frank D McKeon; Tak W Mak; Gerry Melino
Journal:  Nat Rev Mol Cell Biol       Date:  2011-04       Impact factor: 94.444

Review 5.  Rare and common genetic events in type 2 diabetes: what should biologists know?

Authors:  Amélie Bonnefond; Philippe Froguel
Journal:  Cell Metab       Date:  2015-01-29       Impact factor: 27.287

Review 6.  The first 30 years of p53: growing ever more complex.

Authors:  Arnold J Levine; Moshe Oren
Journal:  Nat Rev Cancer       Date:  2009-10       Impact factor: 60.716

Review 7.  Obesity and cancer--mechanisms underlying tumour progression and recurrence.

Authors:  Jiyoung Park; Thomas S Morley; Min Kim; Deborah J Clegg; Philipp E Scherer
Journal:  Nat Rev Endocrinol       Date:  2014-06-17       Impact factor: 43.330

8.  The P72R Polymorphism of p53 Predisposes to Obesity and Metabolic Dysfunction.

Authors:  Che-Pei Kung; Julia I-Ju Leu; Subhasree Basu; Sakina Khaku; Frederick Anokye-Danso; Qin Liu; Donna L George; Rexford S Ahima; Maureen E Murphy
Journal:  Cell Rep       Date:  2016-03-03       Impact factor: 9.423

9.  Studies of the association of Arg72Pro of tumor suppressor protein p53 with type 2 diabetes in a combined analysis of 55,521 Europeans.

Authors:  Kristoffer Sølvsten Burgdorf; Niels Grarup; Johanne Marie Justesen; Marie Neergaard Harder; Daniel Rinse Witte; Torben Jørgensen; Annelli Sandbæk; Torsten Lauritzen; Sten Madsbad; Torben Hansen; Oluf Pedersen
Journal:  PLoS One       Date:  2011-01-20       Impact factor: 3.240

10.  Comprehensive association study of type 2 diabetes and related quantitative traits with 222 candidate genes.

Authors:  Kyle J Gaulton; Cristen J Willer; Yun Li; Laura J Scott; Karen N Conneely; Anne U Jackson; William L Duren; Peter S Chines; Narisu Narisu; Lori L Bonnycastle; Jingchun Luo; Maurine Tong; Andrew G Sprau; Elizabeth W Pugh; Kimberly F Doheny; Timo T Valle; Gonçalo R Abecasis; Jaakko Tuomilehto; Richard N Bergman; Francis S Collins; Michael Boehnke; Karen L Mohlke
Journal:  Diabetes       Date:  2008-08-04       Impact factor: 9.461
  10 in total
  6 in total

1.  Effect of the p53 P72R Polymorphism on Mutant TP53 Allele Selection in Human Cancer.

Authors:  Cristabelle De Souza; Jill Madden; Devin C Koestler; Dennis Minn; Dennis J Montoya; Kay Minn; Alan G Raetz; Zheng Zhu; Wen-Wu Xiao; Neeki Tahmassebi; Harikumara Reddy; Nina Nelson; Anthony N Karnezis; Jeremy Chien
Journal:  J Natl Cancer Inst       Date:  2021-09-04       Impact factor: 13.506

2.  The association between TP53 rs1625895 polymorphism and the risk of sarcopenic obesity in Iranian older adults: a case-control study.

Authors:  Nima Montazeri-Najafabady; Mohammad Hossein Dabbaghmanesh; Nasrin Nasimi; Zahra Sohrabi; Nazanin Chatrabnous
Journal:  BMC Musculoskelet Disord       Date:  2021-05-13       Impact factor: 2.562

3.  Importance of TP53 codon 72 and intron 3 duplication 16 bp polymorphisms and their haplotypes in susceptibility to sarcopenia in Iranian older adults.

Authors:  Nima Montazeri-Najafabady; Mohammad Hossein Dabbaghmanesh; Nasrin Nasimi; Zahra Sohrabi; Alireza Estedlal; Naeimehossadat Asmarian
Journal:  BMC Geriatr       Date:  2022-02-05       Impact factor: 3.921

4.  Tumor Suppressor Par-4 Regulates Complement Factor C3 and Obesity.

Authors:  Nathalia Araujo; James Sledziona; Sunil K Noothi; Ravshan Burikhanov; Nikhil Hebbar; Saptadwipa Ganguly; Tripti Shrestha-Bhattarai; Beibei Zhu; Wendy S Katz; Yi Zhang; Barry S Taylor; Jinze Liu; Li Chen; Heidi L Weiss; Daheng He; Chi Wang; Andrew J Morris; Lisa A Cassis; Mariana Nikolova-Karakashian; Prabhakar R Nagareddy; Olle Melander; B Mark Evers; Philip A Kern; Vivek M Rangnekar
Journal:  Front Oncol       Date:  2022-03-29       Impact factor: 5.738

Review 5.  p53 as a Dichotomous Regulator of Liver Disease: The Dose Makes the Medicine.

Authors:  Jelena Krstic; Markus Galhuber; Tim J Schulz; Michael Schupp; Andreas Prokesch
Journal:  Int J Mol Sci       Date:  2018-03-20       Impact factor: 6.208

Review 6.  p53 Functions in Adipose Tissue Metabolism and Homeostasis.

Authors:  Jelena Krstic; Isabel Reinisch; Michael Schupp; Tim J Schulz; Andreas Prokesch
Journal:  Int J Mol Sci       Date:  2018-09-04       Impact factor: 5.923
  6 in total

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