| Literature DB >> 19344876 |
Hong Shi1, Si-jie Tan, Hua Zhong, Wenwei Hu, Arnold Levine, Chun-jie Xiao, Yi Peng, Xue-bin Qi, Wei-hua Shou, Run-lin Z Ma, Yi Li, Bing Su, Xin Lu.
Abstract
The tumor suppressor p53 is a master sensor of stress. Two human-specific polymorphisms, p53 codon 72 and MDM2 SNP309, influence the activities of p53. There is a tight association between cold winter temperature and p53 Arg72 and between low UV intensity and MDM2 SNP309 G/G in a cohort of 4029 individuals across Eastern Asia that suggests causative selection. Moreover, the two polymorphisms are not coselected. Haplotype-based selection analysis further suggests that this is a striking example of two functional polymorphisms being strongly selected for in human populations in response to environmental stresses.Entities:
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Year: 2009 PMID： 19344876 PMCID： PMC2667983 DOI： 10.1016/j.ajhg.2009.03.009
Source DB: PubMed Journal: Am J Hum Genet ISSN： 0002-9297 Impact factor: 11.025