| Literature DB >> 21427767 |
Arnold J Levine1, Richard Tomasini, Frank D McKeon, Tak W Mak, Gerry Melino.
Abstract
The p53 family of proteins consists of p53, p63 and p73, which are transcription factors that affect both cancer and development. It is now emerging that these proteins also regulate maternal reproduction. Whereas p63 is important for maturation of the egg, p73 ensures normal mitosis in the developing blastocyst. p53 subsequently regulates implantation of the embryo through transcriptional control of leukaemia inhibitory factor. Elucidating the cell biological basis of how these factors regulate female fertility may lead to new approaches to the control of human maternal reproduction.Entities:
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Year: 2011 PMID： 21427767 DOI： 10.1038/nrm3086
Source DB: PubMed Journal: Nat Rev Mol Cell Biol ISSN： 1471-0072 Impact factor: 94.444