Literature DB >> 27652316

Functional versus non-functional intratumor heterogeneity in cancer.

Marc J Williams1, Benjamin Werner2, Trevor A Graham3, Andrea Sottoriva2.   

Abstract

Next-generation sequencing data from human cancers are often difficult to interpret within the context of tumor evolution. We developed a mathematical model describing the accumulation of mutations under neutral evolutionary dynamics and showed that 323/904 cancers (∼30%) from multiple types were consistent with the neutral model of tumor evolution.

Entities:  

Keywords:  Cancer genome; intratumor heterogeneity; mathematical model; mutation rate; neutral expansion; site-frequency spectrum

Year:  2016        PMID： 27652316      PMCID： PMC4972105          DOI： 10.1080/23723556.2016.1162897

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  8 in total

Review 1.  A genetic model for colorectal tumorigenesis.

Authors:  E R Fearon; B Vogelstein
Journal:  Cell       Date:  1990-06-01       Impact factor: 41.582

2.  Observation of Gravitational Waves from a Binary Black Hole Merger.

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A R Williamson; J L Willis; B Willke; M H Wimmer; L Winkelmann; W Winkler; C C Wipf; A G Wiseman; H Wittel; G Woan; J Worden; J L Wright; G Wu; J Yablon; I Yakushin; W Yam; H Yamamoto; C C Yancey; M J Yap; H Yu; M Yvert; A Zadrożny; L Zangrando; M Zanolin; J-P Zendri; M Zevin; F Zhang; L Zhang; M Zhang; Y Zhang; C Zhao; M Zhou; Z Zhou; X J Zhu; M E Zucker; S E Zuraw; J Zweizig
Journal:  Phys Rev Lett       Date:  2016-02-11       Impact factor: 9.161

3.  POPULATION GENETICS OF NEUTRAL MUTATIONS IN EXPONENTIALLY GROWING CANCER CELL POPULATIONS.

Authors:  Rick Durrett
Journal:  Ann Appl Probab       Date:  2013       Impact factor: 1.872

4.  Inferring clonal expansion and cancer stem cell dynamics from DNA methylation patterns in colorectal cancers.

Authors:  Kimberly D Siegmund; Paul Marjoram; Yen-Jung Woo; Simon Tavaré; Darryl Shibata
Journal:  Proc Natl Acad Sci U S A       Date:  2009-03-04       Impact factor: 11.205

5.  Comparative lesion sequencing provides insights into tumor evolution.

Authors:  Siân Jones; Wei-Dong Chen; Giovanni Parmigiani; Frank Diehl; Niko Beerenwinkel; Tibor Antal; Arne Traulsen; Martin A Nowak; Christopher Siegel; Victor E Velculescu; Kenneth W Kinzler; Bert Vogelstein; Joseph Willis; Sanford D Markowitz
Journal:  Proc Natl Acad Sci U S A       Date:  2008-03-12       Impact factor: 11.205

6.  Extremely high genetic diversity in a single tumor points to prevalence of non-Darwinian cell evolution.

Authors:  Shaoping Ling; Zheng Hu; Zuyu Yang; Fang Yang; Yawei Li; Pei Lin; Ke Chen; Lili Dong; Lihua Cao; Yong Tao; Lingtong Hao; Qingjian Chen; Qiang Gong; Dafei Wu; Wenjie Li; Wenming Zhao; Xiuyun Tian; Chunyi Hao; Eric A Hungate; Daniel V T Catenacci; Richard R Hudson; Wen-Hsiung Li; Xuemei Lu; Chung-I Wu
Journal:  Proc Natl Acad Sci U S A       Date:  2015-11-11       Impact factor: 11.205

7.  A Big Bang model of human colorectal tumor growth.

Authors:  Andrea Sottoriva; Haeyoun Kang; Zhicheng Ma; Trevor A Graham; Matthew P Salomon; Junsong Zhao; Paul Marjoram; Kimberly Siegmund; Michael F Press; Darryl Shibata; Christina Curtis
Journal:  Nat Genet       Date:  2015-02-09       Impact factor: 38.330

8.  Identification of neutral tumor evolution across cancer types.

Authors:  Marc J Williams; Benjamin Werner; Chris P Barnes; Trevor A Graham; Andrea Sottoriva
Journal:  Nat Genet       Date:  2016-01-18       Impact factor: 38.330
  8 in total
  3 in total

Review 1.  Genetic and non-genetic clonal diversity in cancer evolution.

Authors:  James R M Black; Nicholas McGranahan
Journal:  Nat Rev Cancer       Date:  2021-03-16       Impact factor: 60.716

Review 2.  Population genetics of clonally transmissible cancers.

Authors:  Máire Ní Leathlobhair; Richard E Lenski
Journal:  Nat Ecol Evol       Date:  2022-07-25       Impact factor: 19.100

3.  Comparative Molecular Life History of Spontaneous Canine and Human Gliomas.

Authors:  Samirkumar B Amin; Kevin J Anderson; C Elizabeth Boudreau; Emmanuel Martinez-Ledesma; Emre Kocakavuk; Kevin C Johnson; Floris P Barthel; Frederick S Varn; Cynthia Kassab; Xiaoyang Ling; Hoon Kim; Mary Barter; Ching C Lau; Chew Yee Ngan; Margaret Chapman; Jennifer W Koehler; James P Long; Andrew D Miller; C Ryan Miller; Brian F Porter; Daniel R Rissi; Christina Mazcko; Amy K LeBlanc; Peter J Dickinson; Rebecca A Packer; Amanda R Taylor; John H Rossmeisl; Kevin D Woolard; Amy B Heimberger; Jonathan M Levine; Roel G W Verhaak
Journal:  Cancer Cell       Date:  2020-02-10       Impact factor: 31.743
  3 in total

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