Literature DB >> 23471293

POPULATION GENETICS OF NEUTRAL MUTATIONS IN EXPONENTIALLY GROWING CANCER CELL POPULATIONS.

Rick Durrett1.   

Abstract

In order to analyze data from cancer genome sequencing projects, we need to be able to distinguish causative, or "driver," mutations from "passenger" mutations that have no selective effect. Toward this end, we prove results concerning the frequency of neutural mutations in exponentially growing multitype branching processes that have been widely used in cancer modeling. Our results yield a simple new population genetics result for the site frequency spectrum of a sample from an exponentially growing population.

Entities:  

Keywords:  Exponentially growing population; cancer model; multitype branching process; site frequency spectrum

Year:  2013        PMID： 23471293      PMCID： PMC3588108          DOI： 10.1214/11-aap824

Source DB:  PubMed          Journal:  Ann Appl Probab            Impact factor:   1.872


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Authors: 
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