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Literature DB >> 2760990

Phenotypic hiding: the carryover of mutations in RNA viruses as shown by detection of mar mutants in influenza virus.

Abstract

When influenza virus monoclonal antibody-resistant (mar) mutants are selected by incubation in vitro with excess antibody, 90 to 99% of the mutants are not detectable. This observation may be explained by encapsidation of mar mutant RNAs within phenotypically wild-type envelopes. This phenotypic hiding can be revealed by selection of mar mutants in vivo after virus uncoating. Using experimental procedures appropriate to detect all viable mar mutants in a virus population, we determined precisely the mutation rates to the mar genotype by the fluctuation test for two nonoverlapping monoclonal antibodies.

Entities: Species

Mesh：

Substances：
Antibodies, Monoclonal

Year: 1989 PMID： 2760990 PMCID： PMC251017 DOI： 10.1128/JVI.63.9.4107-4109.1989

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

27 in total

1. An antigen-binding assay to determine the specificity of monoclonal antibodies against influenza virus and mapping of epitopes.

Authors: J A Lopez; M Guillen; A Sanchez-Fauquier; J A Melero
Journal: J Virol Methods Date: 1986-06 Impact factor: 2.014

2. Marked differences in the antigenic structure of human respiratory syncytial virus F and G glycoproteins.

Authors: B García-Barreno; C Palomo; C Peñas; T Delgado; P Perez-Breña; J A Melero
Journal: J Virol Date: 1989-02 Impact factor: 5.103

3. Conservation and variation in the hemagglutinins of Hong Kong subtype influenza viruses during antigenic drift.

Authors: G W Both; M J Sleigh
Journal: J Virol Date: 1981-09 Impact factor: 5.103

4. Structural identification of the antibody-binding sites of Hong Kong influenza haemagglutinin and their involvement in antigenic variation.

Authors: D C Wiley; I A Wilson; J J Skehel
Journal: Nature Date: 1981-01-29 Impact factor: 49.962

Review 5. The mutation rate and variability of eukaryotic viruses: an analytical review.

Authors: D B Smith; S C Inglis
Journal: J Gen Virol Date: 1987-11 Impact factor: 3.891

6. The antigenic structure of the influenza virus A/PR/8/34 hemagglutinin (H1 subtype).

Authors: A J Caton; G G Brownlee; J W Yewdell; W Gerhard
Journal: Cell Date: 1982-12 Impact factor: 41.582

Review 7. Rapid evolution of RNA genomes.

Authors: J Holland; K Spindler; F Horodyski; E Grabau; S Nichol; S VandePol
Journal: Science Date: 1982-03-26 Impact factor: 47.728

8. Sequence variation in the gene for the immunogenic capsid protein VP1 of foot-and-mouth disease virus type A.

Authors: G N Weddell; D G Yansura; D J Dowbenko; M E Hoatlin; M J Grubman; D M Moore; D G Kleid
Journal: Proc Natl Acad Sci U S A Date: 1985-05 Impact factor: 11.205

9. Antigenic structure of influenza virus haemagglutinin defined by hybridoma antibodies.

Authors: W Gerhard; J Yewdell; M E Frankel; R Webster
Journal: Nature Date: 1981-04-23 Impact factor: 49.962

10. Antigenic determinants of vesicular stomatitis virus: analysis with antigenic variants.

Authors: L Lefrancois; D S Lyles
Journal: J Immunol Date: 1983-01 Impact factor: 5.422

18 in total

1. Density-dependent selection in vesicular stomatitis virus.

Authors: Isabel S Novella; Daniel D Reissig; Claus O Wilke
Journal: J Virol Date: 2004-06 Impact factor: 5.103

2. Quantitation of relative fitness and great adaptability of clonal populations of RNA viruses.

Authors: J J Holland; J C de la Torre; D K Clarke; E Duarte
Journal: J Virol Date: 1991-06 Impact factor: 5.103

3. Mutation frequencies at defined single codon sites in vesicular stomatitis virus and poliovirus can be increased only slightly by chemical mutagenesis.

Authors: J J Holland; E Domingo; J C de la Torre; D A Steinhauer
Journal: J Virol Date: 1990-08 Impact factor: 5.103

Phenotypic hiding: the carryover of mutations in RNA viruses as shown by detection of mar mutants in influenza virus.

1. An antigen-binding assay to determine the specificity of monoclonal antibodies against influenza virus and mapping of epitopes.

2. Marked differences in the antigenic structure of human respiratory syncytial virus F and G glycoproteins.

3. Conservation and variation in the hemagglutinins of Hong Kong subtype influenza viruses during antigenic drift.

4. Structural identification of the antibody-binding sites of Hong Kong influenza haemagglutinin and their involvement in antigenic variation.

Review 5. The mutation rate and variability of eukaryotic viruses: an analytical review.

6. The antigenic structure of the influenza virus A/PR/8/34 hemagglutinin (H1 subtype).

Review 7. Rapid evolution of RNA genomes.

8. Sequence variation in the gene for the immunogenic capsid protein VP1 of foot-and-mouth disease virus type A.

9. Antigenic structure of influenza virus haemagglutinin defined by hybridoma antibodies.

10. Antigenic determinants of vesicular stomatitis virus: analysis with antigenic variants.

1. Density-dependent selection in vesicular stomatitis virus.

2. Quantitation of relative fitness and great adaptability of clonal populations of RNA viruses.

3. Mutation frequencies at defined single codon sites in vesicular stomatitis virus and poliovirus can be increased only slightly by chemical mutagenesis.

4. Fitness alteration of foot-and-mouth disease virus mutants: measurement of adaptability of viral quasispecies.

5. Competition-colonization dynamics in an RNA virus.

6. Biological activities of 'noninfectious' influenza A virus particles.

7. Exponential fitness gains of RNA virus populations are limited by bottleneck effects.

8. Virus mutation frequencies can be greatly underestimated by monoclonal antibody neutralization of virions.

9. Heterogeneity of the mutation rates of influenza A viruses: isolation of mutator mutants.

10. Genetic trans-complementation establishes a new model for influenza virus RNA transcription and replication.