Francesco Soria1,2, Shahrokh F Shariat1,3,4,5, Seth P Lerner6, Hans-Martin Fritsche7, Michael Rink8, Wassim Kassouf9, Philippe E Spiess10, Yair Lotan4, Dingwei Ye11, Mario I Fernández12, Eiji Kikuchi13, Daher C Chade14, Marko Babjuk15, Arthur P Grollman16, George N Thalmann17. 1. Department of Urology, Medical University of Vienna, Vienna, Austria. 2. Division of Urology, Department of Surgical Sciences, San Giovanni Battista Hospital, University of Studies of Torino, Turin, Italy. 3. Karl Landsteiner Institute of Urology and Andrology, Vienna, Austria. 4. Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX, USA. 5. Department of Urology, Weill Cornell Medical College, New York, NY, USA. 6. Scott Department of Urology, Baylor College of Medicine, Houston, TX, USA. 7. Department of Urology, Caritas St. Josef Medical Centre, University of Regensburg, Regensburg, Germany. 8. Department of Urology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. 9. Department of Surgery (Urology), McGill University, Montreal, QC, Canada. 10. Department of Genitourinary Oncology, Moffitt Cancer Center, Tampa, FL, USA. 11. Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, China. 12. Department of Urology, Clinica Alemana, Santiago, Chile. 13. Department of Urology, Keio University School of Medicine, Tokyo, Japan. 14. Urology Department, University of Sao Paulo Medical School and Institute of Cancer, São Paulo, Brazil. 15. Department of Urology, Faculty Hospital Motol, Second Faculty of Medicine, Charles University in Praha, Prague, Czech Republic. 16. Department of Pharmacological Sciences and Department of Medicine, Stony Brook University, Stony Brook, NY, USA. 17. Department of Urology, Bern University Hospital, Bern, Switzerland. george.thalmann@insel.ch.
Abstract
PURPOSE: Upper-tract urothelial carcinoma (UTUC) is a relatively uncommon disease with limited available evidence on specific topics. The purpose of this article was to review the previous literature to summarize the current knowledge about UTUC epidemiology, diagnosis, preoperative evaluation and prognostic assessment. METHODS: Using MEDLINE, a non-systematic review was performed including articles between January 2000 and February 2016. English language original articles, reviews and editorials were selected based on their clinical relevance. RESULTS: UTUC accounts for 5-10 % of all urothelial cancers, with an increasing incidence. UTUC and bladder cancer share some common risk factors, even if they are two different entities regarding practical, biological and clinical characteristics. Aristolochic acid plays an important role in UTUC pathogenesis in certain regions. It is further estimated that approximately 10 % of UTUC are part of the hereditary non-polyposis colorectal cancer spectrum disease. UTUC diagnosis remains mainly based on imaging and endoscopy, but development of new technologies is rapidly changing the diagnosis algorithm. To help the decision-making process regarding surgical treatment, extent of lymphadenectomy and selection of neoadjuvant systemic therapies, predictive tools based on preoperative patient and tumor characteristics have been developed. CONCLUSIONS: Awareness regarding epidemiology, diagnosis, preoperative evaluation and prognostic assessment changes is essential to correctly diagnose and manage UTUC patients, thereby potentially improving their outcomes.
PURPOSE:Upper-tract urothelial carcinoma (UTUC) is a relatively uncommon disease with limited available evidence on specific topics. The purpose of this article was to review the previous literature to summarize the current knowledge about UTUC epidemiology, diagnosis, preoperative evaluation and prognostic assessment. METHODS: Using MEDLINE, a non-systematic review was performed including articles between January 2000 and February 2016. English language original articles, reviews and editorials were selected based on their clinical relevance. RESULTS: UTUC accounts for 5-10 % of all urothelial cancers, with an increasing incidence. UTUC and bladder cancer share some common risk factors, even if they are two different entities regarding practical, biological and clinical characteristics. Aristolochic acid plays an important role in UTUC pathogenesis in certain regions. It is further estimated that approximately 10 % of UTUC are part of the hereditary non-polyposis colorectal cancer spectrum disease. UTUC diagnosis remains mainly based on imaging and endoscopy, but development of new technologies is rapidly changing the diagnosis algorithm. To help the decision-making process regarding surgical treatment, extent of lymphadenectomy and selection of neoadjuvant systemic therapies, predictive tools based on preoperative patient and tumor characteristics have been developed. CONCLUSIONS: Awareness regarding epidemiology, diagnosis, preoperative evaluation and prognostic assessment changes is essential to correctly diagnose and manage UTUC patients, thereby potentially improving their outcomes.
Authors: Ricardo L Favaretto; Shahrokh F Shariat; Caroline Savage; Guilherme Godoy; Daher C Chade; Matthew Kaag; Bernard H Bochner; Jonathan Coleman; Guido Dalbagni Journal: BJU Int Date: 2011-06-01 Impact factor: 5.588
Authors: Giovanni Lughezzani; Maximilian Burger; Vitaly Margulis; Surena F Matin; Giacomo Novara; Morgan Roupret; Shahrokh F Shariat; Christopher G Wood; Richard Zigeuner Journal: Eur Urol Date: 2012-02-23 Impact factor: 20.096
Authors: Paul H Chung; Laura-Maria Krabbe; Oussama M Darwish; Mary E Westerman; Aditya Bagrodia; Bishoy A Gayed; Ahmed Q Haddad; Payal Kapur; Arthur I Sagalowsky; Yair Lotan; Vitaly Margulis Journal: Urol Oncol Date: 2014-07-09 Impact factor: 3.498
Authors: Jamie C Messer; John D Terrell; Michael P Herman; Casey K Ng; Douglas S Scherr; Benjamin Scoll; Stephen A Boorjian; Robert G Uzzo; Mark Wille; Scott E Eggener; Steven M Lucas; Yair Lotan; Shahrokh F Shariat; Jay D Raman Journal: Urol Oncol Date: 2011-09-09 Impact factor: 3.498
Authors: Kazumasa Matsumoto; Giacomo Novara; Amit Gupta; Vitaly Margulis; Thomas J Walton; Marco Roscigno; Casey Ng; Eiji Kikuchi; Richard Zigeuner; Wassim Kassouf; Hans-Martin Fritsche; Vincenzo Ficarra; Guido Martignoni; Stefan Tritschler; Joaquin Carballido Rodriguez; Christian Seitz; Alon Weizer; Mesut Remzi; Jay D Raman; Christian Bolenz; Karim Bensalah; Theresa M Koppie; Pierre I Karakiewicz; Christopher G Wood; Francesco Montorsi; Masatsugu Iwamura; Shahrokh F Shariat Journal: BJU Int Date: 2011-04-20 Impact factor: 5.588
Authors: Wolfgang Otto; Shahrokh F Shariat; Hans-Martin Fritsche; Amit Gupta; Kazumasa Matsumoto; Wassim Kassouf; Guido Martignoni; Thomas J Walton; Stefan Tritschler; Shiro Baba; Patrick J Bastian; Juan I Martínez-Salamanca; Christian Seitz; Armin Pycha; Maximilian Burger; Pierre I Karakiewicz; Vincenzo Ficarra; Giacomo Novara Journal: World J Urol Date: 2011-01-20 Impact factor: 4.226
Authors: Mesut Remzi; Andrea Haitel; Vitaly Margulis; Pierre Karakiewicz; Pierre Karakiewizc; Francesco Montorsi; Eiji Kikuchi; Richard Zigeuner; Alon Weizer; Christian Bolenz; Karim Bensalah; Nazareno Suardi; Jay D Raman; Yair Lotan; Matthias Waldert; Casey K Ng; Mario Fernández; Theresa M Koppie; Philipp Ströbel; Wareef Kabbani; Masaru Murai; Cord Langner; Marco Roscigno; Jeffrey Wheat; Charles C Guo; Christopher G Wood; Shahrokh F Shariat Journal: BJU Int Date: 2008-10-16 Impact factor: 5.588
Authors: Jean V Joseph; Ralph Brasacchio; Chunkit Fung; Jay Reeder; Kevin Bylund; Deepak Sahasrabudhe; Shu Yuan Yeh; Ahmed Ghazi; Patrick Fultz; Deborah Rubens; Guan Wu; Eric Singer; Edward Schwarz; Supriya Mohile; James Mohler; Dan Theodorescu; Yi Fen Lee; Paul Okunieff; David McConkey; Hani Rashid; Chawnshang Chang; Yves Fradet; Khurshid Guru; Janet Kukreja; Gerald Sufrin; Yair Lotan; Howard Bailey; Katia Noyes; Seymour Schwartz; Kathy Rideout; Gennady Bratslavsky; Steven C Campbell; Ithaar Derweesh; Per-Anders Abrahamsson; Mark Soloway; Leonard Gomella; Dragan Golijanin; Robert Svatek; Thomas Frye; Seth Lerner; Ganesh Palapattu; George Wilding; Michael Droller; Donald Trump Journal: Bladder Cancer Date: 2018-10-03
Authors: Adithya Balasubramanian; Michael J Metcalfe; Gavin Wagenheim; Lianchun Xiao; John Papadopoulos; Neema Navai; John W Davis; Jose A Karam; Ashish M Kamat; Christopher G Wood; Colin P Dinney; Surena F Matin Journal: World J Urol Date: 2018-05-26 Impact factor: 4.226
Authors: Joseph Brito; Borivoj Golijanin; Ohad Kott; Anna Moshnikova; Catrina Mueller-Leonhard; Boris Gershman; Oleg A Andreev; Yana K Reshetnyak; Ali Amin; Dragan Golijanin Journal: Urology Date: 2019-01-16 Impact factor: 2.649
Authors: Marco Serafino Grande; Davide Campobasso; Raffaele Inzillo; Matteo Moretti; Francesco Facchini; Jean Emmanuel Kwe; Antonio Frattini Journal: Indian J Urol Date: 2021-04-01