Literature DB >> 27600581

Visit-to-Visit Blood Pressure Variability and Mortality and Cardiovascular Outcomes Among Older Adults: The Health, Aging, and Body Composition Study.

Chenkai Wu1, Michael G Shlipak2,3, Robert S Stawski4, Carmen A Peralta2,3, Bruce M Psaty, Tamara B Harris5, Suzanne Satterfield6, Eric J Shiroma7, Anne B Newman8, Michelle C Odden9.   

Abstract

BACKGROUND: Level of blood pressure (BP) is strongly associated with cardiovascular (CV) events and mortality. However, it is questionable whether mean BP can fully capture BP-related vascular risk. Increasing attention has been given to the value of visit-to-visit BP variability.
METHODS: We examined the association of visit-to-visit BP variability with mortality, incident myocardial infarction (MI), and incident stroke among 1,877 well-functioning elders in the Health, Aging, and Body Composition Study. We defined visit-to-visit diastolic BP (DBP) and systolic BP (SBP) variability as the root-mean-square error of person-specific linear regression of BP as a function of time. Alternatively, we counted the number of considerable BP increases and decreases (separately; 10mm Hg for DBP and 20mm Hg for SBP) between consecutive visits for each individual.
RESULTS: Over an average follow-up of 8.5 years, 623 deaths (207 from CV disease), 153 MIs, and 156 strokes occurred. The median visit-to-visit DBP and SBP variability was 4.96 mmHg and 8.53 mmHg, respectively. After multivariable adjustment, visit-to-visit DBP variability was related to higher all-cause (hazard ratio (HR) = 1.18 per 1 SD, 95% confidence interval (CI) = 1.01-1.37) and CV mortality (HR = 1.35, 95% CI = 1.05-1.73). Additionally, individuals having more considerable decreases of DBP (≥10mm Hg between 2 consecutive visits) had higher risk of all-cause (HR = 1.13, 95% CI = 0.99-1.28) and CV mortality (HR = 1.30, 95% CI = 1.05-1.61); considerable increases of SBP (≥20mm Hg) were associated with higher risk of all-cause (HR = 1.18, 95% CI = 1.03-1.36) and CV mortality (HR = 1.37, 95% CI = 1.08-1.74).
CONCLUSIONS: Visit-to-visit DBP variability and considerable changes in DBP and SBP were risk factors for mortality in the elderly. © American Journal of Hypertension, Ltd 2016. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Entities:  

Keywords:  aged.; blood pressure; blood pressure variability; hypertension; mortality; myocardial infarction; stroke

Mesh:

Year:  2016        PMID: 27600581      PMCID: PMC5225946          DOI: 10.1093/ajh/hpw106

Source DB:  PubMed          Journal:  Am J Hypertens        ISSN: 0895-7061            Impact factor:   2.689


  31 in total

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Journal:  Arch Neurol       Date:  2010-05

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6.  Body weight dynamics and their association with physical function and mortality in older adults: the Cardiovascular Health Study.

Authors:  Alice M Arnold; Anne B Newman; Mary Cushman; Jingzhong Ding; Stephen Kritchevsky
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7.  Visit-to-Visit Variability of Blood Pressure and Coronary Heart Disease, Stroke, Heart Failure, and Mortality: A Cohort Study.

Authors:  Paul Muntner; Jeff Whittle; Amy I Lynch; Lisandro D Colantonio; Lara M Simpson; Paula T Einhorn; Emily B Levitan; Paul K Whelton; William C Cushman; Gail T Louis; Barry R Davis; Suzanne Oparil
Journal:  Ann Intern Med       Date:  2015-09-01       Impact factor: 25.391

8.  Relationship between longitudinal changes in blood pressure and stroke incidence.

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Review 10.  Blood pressure variability and cardiovascular disease: systematic review and meta-analysis.

Authors:  Sarah L Stevens; Sally Wood; Constantinos Koshiaris; Kathryn Law; Paul Glasziou; Richard J Stevens; Richard J McManus
Journal:  BMJ       Date:  2016-08-09
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7.  Exploring the Dynamics of Week-to-Week Blood Pressure in Nursing Home Residents Before Death.

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8.  Prognostic importance of long-term SBP variability in high-risk hypertension.

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9.  Addressing Diabetes and Poorly Controlled Hypertension: Pragmatic mHealth Self-Management Intervention.

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10.  Refining determinants of associations of visit-to-visit blood pressure variability with cardiovascular risk: results from the Action to Control Cardiovascular Risk in Diabetes Trial.

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