Literature DB >> 2757440

Effect of surgical blood loss and volume replacement on antibiotic pharmacokinetics.

D Sue1, T A Salazar, K Turley, B J Guglielmo.   

Abstract

Antibiotic prophylaxis is used widely to prevent postoperative infection associated with cardiac operations. The influence of perioperative blood loss on antibiotic pharmacokinetics has not been well studied. Plasma cefazolin sodium samples from 8 patients undergoing a cardiac operation were collected postoperatively and analyzed. The results suggest that blood loss has a minimal effect on the elimination of cefazolin and that therapeutic concentrations are maintained without altering the dosage regimen.

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Year:  1989        PMID： 2757440     DOI： 10.1016/0003-4975(89)90020-9

Source DB:  PubMed          Journal:  Ann Thorac Surg        ISSN： 0003-4975            Impact factor:   4.330


  6 in total

1.  Pharmacokinetics and protein binding of cefazolin in morbidly obese patients.

Authors:  Simone van Kralingen; Margot Taks; Jeroen Diepstraten; Ewoudt M van de Garde; Eric P van Dongen; Marinus J Wiezer; Bert van Ramshorst; Bart Vlaminckx; Vera H Deneer; Catherijne A Knibbe
Journal:  Eur J Clin Pharmacol       Date:  2011-04-16       Impact factor: 2.953

2.  A prospective randomized study to assess the optimal duration of intravenous antimicrobial prophylaxis in elective gastric cancer surgery.

Authors:  Norihiro Haga; Hideyuki Ishida; Toru Ishiguro; Kensuke Kumamoto; Keiichiro Ishibashi; Yoshitaka Tsuji; Tatsuya Miyazaki
Journal:  Int Surg       Date:  2012 Apr-Jun

3.  Physiological modeling for indirect evaluation of drug tissular pharmacokinetics under non-steady-state conditions: an example of antimicrobial prophylaxis during liver surgery.

Authors:  Franck Lagneau; Jean Marty; Pascale Beyne; Michel Tod
Journal:  J Pharmacokinet Pharmacodyn       Date:  2005-02       Impact factor: 2.745

4.  Microbiological efficacy and pharmacokinetics of prophylactic antibiotics in liver transplant patients.

Authors:  P M Arnow; K Furmaga; J P Flaherty; D George
Journal:  Antimicrob Agents Chemother       Date:  1992-10       Impact factor: 5.191

5.  Comparative Pharmacokinetics of Gallic Acid After Oral Administration of Gallic Acid Monohydrate in Normal and Isoproterenol-Induced Myocardial Infarcted Rats.

Authors:  Zhe Yu; Fan Song; Yu-Chen Jin; Wei-Min Zhang; Ya Zhang; En-Jun Liu; Dan Zhou; Lin-Lin Bi; Qian Yang; Hua Li; Bang-Le Zhang; Si-Wang Wang
Journal:  Front Pharmacol       Date:  2018-04-06       Impact factor: 5.810

6.  Potentially clinically relevant concentrations of Cefazolin, Midazolam, Propofol, and Sufentanil in auto-transfused blood in congenital cardiac surgery.

Authors:  Gerda A Zeilmaker-Roest; Annewil van Saet; Joost van Rosmalen; Soma Bahmany; Antony van Dijk; Enno D Wildschut; Dick Tibboel; Ad J J C Bogers
Journal:  J Cardiothorac Surg       Date:  2018-06-08       Impact factor: 1.637
  6 in total

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