Literature DB >> 23102084

A prospective randomized study to assess the optimal duration of intravenous antimicrobial prophylaxis in elective gastric cancer surgery.

Norihiro Haga1, Hideyuki Ishida, Toru Ishiguro, Kensuke Kumamoto, Keiichiro Ishibashi, Yoshitaka Tsuji, Tatsuya Miyazaki.   

Abstract

The duration of antimicrobial prophylaxis in gastric cancer surgery is not yet established. This prospective randomized study was performed to confirm the noninferiority of single-dose versus multiple-dose antimicrobial prophylaxis in terms of the incidence of surgical-site infection in gastric cancer surgery. Three hundred twenty-five patients undergoing elective resection for gastric cancer were randomized to receive only single-dose cefazolin (1 g) during surgery (single-dose group) or an additional 5 doses every 12 hours postoperatively (multiple-dose group). The overall incidence of surgical-site infections was 9.1% in the single-dose group and 6.2% in the multiple-dose group [difference (95% confidence interval): -2.9% (-5.9%-0.0%)]. Multivariate logistic regression analysis identified blood loss, being overweight, and advanced age as significant independent risk factors for surgical-site infection. Single-dose antimicrobial prophylaxis seemed to be acceptable, and choosing multiple-dose prophylaxis may have little impact on the prevention of surgical-site infections in elective gastric cancer surgery.

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Year:  2012        PMID： 23102084      PMCID： PMC3723203          DOI： 10.9738/CC91.1

Source DB:  PubMed          Journal:  Int Surg        ISSN： 0020-8868


  26 in total

1.  Surgical antibiotic prophylaxis in smaller hospitals.

Authors:  Noleen J Bennett; Ann L Bull; David R Dunt; Philip L Russo; Denis W Spelman; Michael J Richards
Journal:  ANZ J Surg       Date:  2006-08       Impact factor: 1.872

2.  Prolonged antibiotic prophylaxis longer than 24 hours does not decrease surgical site infection after elective gastric and colorectal surgery.

Authors:  Taketoshi Suehiro; Teijiro Hirashita; Shinichiro Araki; Takashi Matsumata; Soichi Tsutsumi; Erito Mochiki; Hiroyuki Kato; Takayuki Asao; Hiroyuki Kuwano
Journal:  Hepatogastroenterology       Date:  2008 Sep-Oct

Review 3.  Drain versus no-drain after gastrectomy for patients with advanced gastric cancer: systematic review and meta-analysis.

Authors:  Hai Peng Liu; You Cheng Zhang; Yu Long Zhang; Lan Ning Yin; Jun Wang
Journal:  Dig Surg       Date:  2011-05-04       Impact factor: 2.588

Review 4.  Abdominal drainage versus no drainage post gastrectomy for gastric cancer.

Authors:  Zhen Wang; Junqiang Chen; Ka Su; Zhiyong Dong
Journal:  Cochrane Database Syst Rev       Date:  2011-08-10

5.  Short-term intravenous antimicrobial prophylaxis in combination with preoperative oral antibiotics on surgical site infection and methicillin-resistant Staphylococcus aureus infection in elective colon cancer surgery: results of a prospective randomized trial.

Authors:  Keiichiro Ishibashi; Kouki Kuwabara; Toru Ishiguro; Tomonori Ohsawa; Norimichi Okada; Tatsuya Miyazaki; Masaru Yokoyama; Hideyuki Ishida
Journal:  Surg Today       Date:  2009-12-08       Impact factor: 2.549

6.  Age as an independent risk factor for surgical site infections in a large gastrointestinal surgery cohort in Japan.

Authors:  M Utsumi; J Shimizu; A Miyamoto; K Umeshita; T Kobayashi; M Monden; K Makimoto
Journal:  J Hosp Infect       Date:  2010-07       Impact factor: 3.926

7.  Antibiotic prophylaxis in high-risk biliary operations: multicenter trial of single preoperative ceftriaxone versus multidose cefazolin.

Authors:  J M Kellum; S Gargano; S L Gorbach; C Talcof; L E Curtis; B Weiner; M McCoobery; J S Tan; T Kelly; D Wagner
Journal:  Am J Surg       Date:  1984-10-19       Impact factor: 2.565

Review 8.  Assessing obesity: classification and epidemiology.

Authors:  J C Seidell; K M Flegal
Journal:  Br Med Bull       Date:  1997       Impact factor: 4.291

9.  Surgical site infection risk factors identified by multivariate analysis for patient undergoing laparoscopic, open colon, and gastric surgery.

Authors:  Eiko Imai; Masakazu Ueda; Kent Kanao; Tetsuro Kubota; Hirotoshi Hasegawa; Kazuyuki Omae; Masaki Kitajima
Journal:  Am J Infect Control       Date:  2008-10-03       Impact factor: 2.918

10.  Multicenter phase II study of antimicrobial prophylaxis in low-risk patients undergoing distal gastrectomy for gastric cancer.

Authors:  Hiroshi Imamura; Hiroshi Furukawa; Shohei Iijima; Seichi Sugihara; Toshimasa Tsujinaka; Hideaki Tsukuma; Toshio Shimokawa
Journal:  Gastric Cancer       Date:  2006       Impact factor: 7.370
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  5 in total

1.  The Japan Society for Surgical Infection: guidelines for the prevention, detection, and management of gastroenterological surgical site infection, 2018.

Authors:  Hiroki Ohge; Toshihiko Mayumi; Seiji Haji; Yuichi Kitagawa; Masahiro Kobayashi; Motomu Kobayashi; Toru Mizuguchi; Yasuhiko Mohri; Fumie Sakamoto; Junzo Shimizu; Katsunori Suzuki; Motoi Uchino; Chizuru Yamashita; Masahiro Yoshida; Koichi Hirata; Yoshinobu Sumiyama; Shinya Kusachi
Journal:  Surg Today       Date:  2020-12-15       Impact factor: 2.549

2.  Surgical Antimicrobial Prophylaxis in Abdominal Surgery for Neonates and Paediatrics: A RAND/UCLA Appropriateness Method Consensus Study.

Authors:  Sonia Bianchini; Erika Rigotti; Sara Monaco; Laura Nicoletti; Cinzia Auriti; Elio Castagnola; Giorgio Conti; Luisa Galli; Mario Giuffrè; Stefania La Grutta; Laura Lancella; Andrea Lo Vecchio; Giuseppe Maglietta; Nicola Petrosillo; Carlo Pietrasanta; Nicola Principi; Simonetta Tesoro; Elisabetta Venturini; Giorgio Piacentini; Mario Lima; Annamaria Staiano; Susanna Esposito
Journal:  Antibiotics (Basel)       Date:  2022-02-21

Review 3.  Antimicrobial Prophylaxis Reduces the Rate of Surgical Site Infection in Upper Gastrointestinal Surgery: A Systematic Review.

Authors:  Luigi Marano; Ludovico Carbone; Gianmario Edoardo Poto; Natale Calomino; Alessandro Neri; Riccardo Piagnerelli; Andrea Fontani; Luigi Verre; Vinno Savelli; Franco Roviello; Daniele Marrelli
Journal:  Antibiotics (Basel)       Date:  2022-02-10

4.  Extended Perioperative Antibiotic Coverage in Conjunction with Intraoperative Bile Cultures Decreases Infectious Complications after Pancreaticoduodenectomy.

Authors:  Amir H Fathi; Terence Jackson; Mehdi Barati; Babak Eghbalieh; Kelly A Siegel; Christopher T Siegel
Journal:  HPB Surg       Date:  2016-04-11

5.  Changes in bacterial number at different sites of oral cavity during perioperative oral care management in gastrointestinal cancer patients: preliminary study.

Authors:  Tomoko Kawano; Hideo Shigeishi; Eri Fukada; Takamichi Yanagisawa; Nobukazu Kuroda; Toshinobu Takemoto; Masaru Sugiyama
Journal:  J Appl Oral Sci       Date:  2018-06-18       Impact factor: 2.698
  5 in total

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