Nitin Shivappa1,2,3, James R Hébert1,2,3, Antonella Zucchetto4, Maurizio Montella5, Massimo Libra6, Werner Garavello7, Marta Rossi8, Carlo La Vecchia8, Diego Serraino4. 1. a South Carolina Statewide Cancer Prevention and Control Program, University of South Carolina , Columbia , South Carolina , USA. 2. b Department of Epidemiology and Biostatistics , Arnold School of Public Health, University of South Carolina , Columbia , South Carolina , USA. 3. c Connecting Health Innovations LLC , Columbia , South Carolina , USA. 4. d Epidemiology and Biostatistics Unit, CRO Aviano National Cancer Institute , Aviano , Italy. 5. e Department of Epidemiology , 'Fondazione G. Pascale', Istituto Nazionale Tumori , Naples , Italy. 6. f Department of Biomedical and Biotechnological Sciences , University of Catania , Catania , Italy. 7. g Department of Surgery and Translational Medicine , University of Milano-Bicocca , Milan , Italy. 8. h Department of Clinical Sciences and Community Health , Università degli Studi di Milano , Milan , Italy.
Abstract
PURPOSE: Components of diet can modulate inflammation and therefore may have an important role in the development of nasopharyngeal carcinoma (NPC). Little is known about the inflammatory potential of diet in relation to nasopharyngeal carcinogenesis. METHODS: Data from an Italian multicenter case-control study conducted between 1992 and 2008 and including 198 cases with incident, histologically confirmed NPC, and 594 controls hospitalized for acute nonneoplastic diseases were used to estimate the relation between a dietary inflammatory index (DII) and the risk of NPC. The DII was computed based on the intake of selected dietary factors assessed by a validated 78-item food frequency questionnaire. Logistic regression models were used to estimate odds ratios (ORs) adjusted for study center, place of living, sex, age, year of interview, education, tobacco smoking, alcohol drinking, and energy intake using the residual method. RESULTS: Subjects with higher DII scores had an increased risk of NPC, with each DII point increasing risk by nearly 20% [OR: 1.19; 95% confidence interval (CI): 1.05-1.36]. Compared to subjects in the lowest DII tertile, those in the highest tertile had >60% higher risk of NPC (OR: 1.64; 95% CI: 1.06-2.55; Ptrend = 0.04). CONCLUSION: These results indicate that inflammatory potential of diet plays a role in NPC.
PURPOSE: Components of diet can modulate inflammation and therefore may have an important role in the development of nasopharyngeal carcinoma (NPC). Little is known about the inflammatory potential of diet in relation to nasopharyngeal carcinogenesis. METHODS: Data from an Italian multicenter case-control study conducted between 1992 and 2008 and including 198 cases with incident, histologically confirmed NPC, and 594 controls hospitalized for acute nonneoplastic diseases were used to estimate the relation between a dietary inflammatory index (DII) and the risk of NPC. The DII was computed based on the intake of selected dietary factors assessed by a validated 78-item food frequency questionnaire. Logistic regression models were used to estimate odds ratios (ORs) adjusted for study center, place of living, sex, age, year of interview, education, tobacco smoking, alcohol drinking, and energy intake using the residual method. RESULTS: Subjects with higher DII scores had an increased risk of NPC, with each DII point increasing risk by nearly 20% [OR: 1.19; 95% confidence interval (CI): 1.05-1.36]. Compared to subjects in the lowest DII tertile, those in the highest tertile had >60% higher risk of NPC (OR: 1.64; 95% CI: 1.06-2.55; Ptrend = 0.04). CONCLUSION: These results indicate that inflammatory potential of diet plays a role in NPC.
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Authors: Nitin Shivappa; James R Hébert; Ernst R Rietzschel; Marc L De Buyzere; Michel Langlois; Evi Debruyne; Ascensión Marcos; Inge Huybrechts Journal: Br J Nutr Date: 2015-02-02 Impact factor: 3.718
Authors: Adrian D Wood; Anna A Strachan; Frank Thies; Lorna S Aucott; David M Reid; Antonia C Hardcastle; Alexandra Mavroeidi; William G Simpson; Garry G Duthie; Helen M Macdonald Journal: Br J Nutr Date: 2014-10-28 Impact factor: 3.718
Authors: S Franceschi; E Negri; S Salvini; A Decarli; M Ferraroni; R Filiberti; A Giacosa; R Talamini; O Nanni; G Panarello Journal: Eur J Cancer Date: 1993 Impact factor: 9.162
Authors: Michael D Wirth; James Burch; Nitin Shivappa; John M Violanti; Cecil M Burchfiel; Desta Fekedulegn; Michael E Andrew; Tara A Hartley; Diane B Miller; Anna Mnatsakanova; Luenda E Charles; Susan E Steck; Thomas G Hurley; John E Vena; James R Hébert Journal: J Occup Environ Med Date: 2014-09 Impact factor: 2.162
Authors: Nitin Shivappa; Antonella Zucchetto; Maurizio Montella; Diego Serraino; Susan E Steck; Carlo La Vecchia; James R Hébert Journal: Br J Nutr Date: 2015-06-08 Impact factor: 3.718
Authors: Nitin Shivappa; Susan E Steck; Thomas G Hurley; James R Hussey; Yunsheng Ma; Ira S Ockene; Fred Tabung; James R Hébert Journal: Public Health Nutr Date: 2013-10-10 Impact factor: 4.022
Authors: Nitin Shivappa; James R Hébert; Valentina Rosato; Werner Garavello; Diego Serraino; Carlo La Vecchia Journal: Int J Cancer Date: 2017-05-09 Impact factor: 7.396
Authors: Angela L Mazul; Nitin Shivappa; James R Hébert; Susan E Steck; Nidia Rodriguez-Ormaza; Mark Weissler; Andrew F Olshan; Jose P Zevallos Journal: Int J Cancer Date: 2018-07-26 Impact factor: 7.396
Authors: Catherine M Phillips; Ling-Wei Chen; Barbara Heude; Jonathan Y Bernard; Nicholas C Harvey; Liesbeth Duijts; Sara M Mensink-Bout; Kinga Polanska; Giulia Mancano; Matthew Suderman; Nitin Shivappa; James R Hébert Journal: Nutrients Date: 2019-08-12 Impact factor: 5.717