Nitin Shivappa1,2, James R Hébert1,2, Mohsen Karamati3, Seyedeh-Elaheh Shariati-Bafghi3, Bahram Rashidkhani4. 1. Cancer Prevention and Control Program, University of South Carolina, Columbia, SC, 29208, USA. 2. Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC, 29208, USA. 3. Department of Nutrition Sciences, Varastegan Institute for Medical Sciences, Mashhad, Iran. 4. Community Nutrition Department, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute (WHO Collaborating Center), Shahid Beheshti University of Medical Sciences, Tehran, Iran. rashidkhani@yahoo.com.
Abstract
PURPOSE: Diet has been shown to be associated with bone mineral density (BMD); however, the inflammatory potential of diet in modulating BMD has not yet been studied. METHODS: We examined the association between a newly developed dietary inflammatory index (DII) and BMD in a sample of postmenopausal Iranian women. In this cross-sectional study, 160 postmenopausal women aged 50-85 years were studied and their femoral neck and lumbar spine BMDs were measured by dual-energy X-ray absorptiometry. The DII was computed based on dietary intake assessed using a previously validated, 168-item semiquantitative food frequency questionnaire. Logistic and linear regression models were fit to derive beta estimates and odds ratios (ORs), with DII fit as continuous and as a dichotomous variable. RESULTS: After adjusting for potential confounders, women with higher DII scores were more likely to have BMD below the median in the lumbar spine with the DII being used as both a continuous variable [ORcontinuous 1.64, 95 % confidence interval (CI) 1.11-2.43, p value = 0.01; one-unit increase corresponding to ≈17 % of its range in the current study] and a categorical variable (ORDII>-0.06/≤ 2.30, 95 % CI 1.05-5.07, p value = 0.04). Similar associations were observed when lumbar spine BMD was used as a continuous outcome. No significant association was observed with BMD in femoral neck, although the direction was along expected lines. CONCLUSION: These data suggest a pro-inflammatory diet, as indicated by increasing DII score, may be a risk factor for lower BMD in lumbar spine in postmenopausal Iranian women.
PURPOSE: Diet has been shown to be associated with bone mineral density (BMD); however, the inflammatory potential of diet in modulating BMD has not yet been studied. METHODS: We examined the association between a newly developed dietary inflammatory index (DII) and BMD in a sample of postmenopausal Iranian women. In this cross-sectional study, 160 postmenopausal women aged 50-85 years were studied and their femoral neck and lumbar spine BMDs were measured by dual-energy X-ray absorptiometry. The DII was computed based on dietary intake assessed using a previously validated, 168-item semiquantitative food frequency questionnaire. Logistic and linear regression models were fit to derive beta estimates and odds ratios (ORs), with DII fit as continuous and as a dichotomous variable. RESULTS: After adjusting for potential confounders, women with higher DII scores were more likely to have BMD below the median in the lumbar spine with the DII being used as both a continuous variable [ORcontinuous 1.64, 95 % confidence interval (CI) 1.11-2.43, p value = 0.01; one-unit increase corresponding to ≈17 % of its range in the current study] and a categorical variable (ORDII>-0.06/≤ 2.30, 95 % CI 1.05-5.07, p value = 0.04). Similar associations were observed when lumbar spine BMD was used as a continuous outcome. No significant association was observed with BMD in femoral neck, although the direction was along expected lines. CONCLUSION: These data suggest a pro-inflammatory diet, as indicated by increasing DII score, may be a risk factor for lower BMD in lumbar spine in postmenopausal Iranian women.
Entities:
Keywords:
Bone mineral density; Dietary inflammatory index; Inflammation; Iran; Postmenopausal women
Authors: Nitin Shivappa; Anna E Prizment; Cindy K Blair; David R Jacobs; Susan E Steck; James R Hébert Journal: Cancer Epidemiol Biomarkers Prev Date: 2014-08-25 Impact factor: 4.254
Authors: Nitin Shivappa; James R Hébert; Ernst R Rietzschel; Marc L De Buyzere; Michel Langlois; Evi Debruyne; Ascensión Marcos; Inge Huybrechts Journal: Br J Nutr Date: 2015-02-02 Impact factor: 3.718
Authors: Isolde Sommer; Arja T Erkkilä; Ritva Järvinen; Jaakko Mursu; Joonas Sirola; Jukka S Jurvelin; Heikki Kröger; Marjo Tuppurainen Journal: Public Health Nutr Date: 2012-07-17 Impact factor: 4.022
Authors: Michael D Wirth; James Burch; Nitin Shivappa; John M Violanti; Cecil M Burchfiel; Desta Fekedulegn; Michael E Andrew; Tara A Hartley; Diane B Miller; Anna Mnatsakanova; Luenda E Charles; Susan E Steck; Thomas G Hurley; John E Vena; James R Hébert Journal: J Occup Environ Med Date: 2014-09 Impact factor: 2.162
Authors: Nitin Shivappa; Susan E Steck; Thomas G Hurley; James R Hussey; Yunsheng Ma; Ira S Ockene; Fred Tabung; James R Hébert Journal: Public Health Nutr Date: 2013-10-10 Impact factor: 4.022
Authors: Nitin Shivappa; Susan E Steck; Thomas G Hurley; James R Hussey; James R Hébert Journal: Public Health Nutr Date: 2013-08-14 Impact factor: 4.022
Authors: Sabrina E Noel; Kelsey M Mangano; Josiemer Mattei; John L Griffith; Bess Dawson-Hughes; Sherman Bigornia; Katherine L Tucker Journal: Am J Clin Nutr Date: 2020-06-01 Impact factor: 7.045
Authors: Tonya Orchard; Vedat Yildiz; Susan E Steck; James R Hébert; Yunsheng Ma; Jane A Cauley; Wenjun Li; Yasmin Mossavar-Rahmani; Karen C Johnson; Maryam Sattari; Meryl LeBoff; Jean Wactawski-Wende; Rebecca D Jackson Journal: J Bone Miner Res Date: 2017-02-21 Impact factor: 6.741
Authors: Nitin Shivappa; Cindy K Blair; Anna E Prizment; David R Jacobs; Susan E Steck; James R Hébert Journal: Eur J Nutr Date: 2015-07-01 Impact factor: 5.614
Authors: Alexis Sokol; Michael D Wirth; Marta Manczuk; Nitin Shivappa; Katarzyna Zatonska; Thomas G Hurley; James R Hébert Journal: Nutr Res Date: 2016-04-19 Impact factor: 3.315
Authors: Nitin Shivappa; James R Hébert; Antonella Zucchetto; Maurizio Montella; Massimo Libra; Werner Garavello; Marta Rossi; Carlo La Vecchia; Diego Serraino Journal: Nutr Cancer Date: 2016-08-26 Impact factor: 2.900