Chuyang Lin1,2, Su-Mei Cao1,3, Ellen T Chang4,5, Zhiwei Liu6, Yonglin Cai7,8, Zhe Zhang9,10, Guomin Chen11, Qi-Hong Huang12, Shang-Hang Xie1,3, Yu Zhang3, Jingping Yun3, Wei-Hua Jia3, Yuming Zheng7,8, Jian Liao13, Yufeng Chen6, Longde Lin10, Qing Liu1,3, Ingemar Ernberg14, Guangwu Huang9,10, Yi Zeng11, Yi-Xin Zeng3,15, Hans-Olov Adami6,16, Weimin Ye1,3,6. 1. Department of Cancer Prevention Center, Sun Yat-Sen University Cancer Center, Guangzhou, China. 2. School of Public Health, Sun Yat-Sen University, Guangzhou, China. 3. State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, and Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-Sen University Cancer Center, Guangzhou, China. 4. Center for Health Sciences, Exponent, Inc, Menlo Park, California. 5. Stanford Cancer Institute, Stanford, California. 6. Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden. 7. Department of Clinical Laboratory, Wuzhou Red Cross Hospital, Wuzhou, China. 8. Wuzhou Health System Key Laboratory for Nasopharyngeal Carcinoma Etiology and Molecular Mechanism, Wuzhou, China. 9. Department of Otolaryngology-Head and Neck Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning, China. 10. Key Laboratory of High-Incidence-Tumor Prevention and Treatment (Guangxi Medical University), Ministry of Education, Nanning, China. 11. State Key Laboratory for Infectious Diseases Prevention and Control, Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China. 12. Sihui Cancer Institute, Sihui, China. 13. Cangwu Institute for Nasopharyngeal Carcinoma Control and Prevention, Wuzhou, China. 14. Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden. 15. Beijing Hospital, Beijing, China. 16. Clinical Effectiveness Research Group, Institute of Health and Society, University of Oslo, Oslo, Norway.
Abstract
BACKGROUND: An association between a nonmedicinal herbal diet and nasopharyngeal carcinoma (NPC) has often been hypothesized but never thoroughly investigated. METHODS: This study enrolled a total of 2469 patients with incident NPC and 2559 population controls from parts of Guangdong and Guangxi Provinces in southern China between 2010 and 2014. Questionnaire information was collected on the intake of traditional herbal tea and herbal soup as well as the specific herbal plants used in soups and other potentially confounding lifestyle factors. Multivariate logistic regression models were used to estimate odds ratios (ORs) with 95% confidence intervals (CIs) for the NPC risk in association with herbal tea and soup intake. RESULTS: Ever consumption of herbal tea was not associated with NPC risk (OR, 1.03; 95% CI, 0.91-1.17). An inverse association was observed for NPC among ever drinkers of herbal soup (OR, 0.78; 95% CI, 0.67-0.90) but without any monotonic trend with an increasing frequency or duration of herbal soup consumption. Inverse associations with NPC risk were detected with 9 herbal plants used in herbal soup, including Ziziphus jujuba, Fructus lycii, Codonopsis pilosula, Astragalus membranaceus, Semen coicis, Smilax glabra, Phaseolus calcaratus, Morinda officinalis, and Atractylodes macrocephala (OR range, 0.31-0.79). CONCLUSIONS: Consuming herbal soups including specific plants, but not herbal tea, was inversely associated with NPC. If replicated, these results might provide potential for NPC prevention in endemic areas.
BACKGROUND: An association between a nonmedicinal herbal diet and nasopharyngeal carcinoma (NPC) has often been hypothesized but never thoroughly investigated. METHODS: This study enrolled a total of 2469 patients with incident NPC and 2559 population controls from parts of Guangdong and Guangxi Provinces in southern China between 2010 and 2014. Questionnaire information was collected on the intake of traditional herbal tea and herbal soup as well as the specific herbal plants used in soups and other potentially confounding lifestyle factors. Multivariate logistic regression models were used to estimate odds ratios (ORs) with 95% confidence intervals (CIs) for the NPC risk in association with herbal tea and soup intake. RESULTS: Ever consumption of herbal tea was not associated with NPC risk (OR, 1.03; 95% CI, 0.91-1.17). An inverse association was observed for NPC among ever drinkers of herbal soup (OR, 0.78; 95% CI, 0.67-0.90) but without any monotonic trend with an increasing frequency or duration of herbal soup consumption. Inverse associations with NPC risk were detected with 9 herbal plants used in herbal soup, including Ziziphus jujuba, Fructus lycii, Codonopsis pilosula, Astragalus membranaceus, Semen coicis, Smilax glabra, Phaseolus calcaratus, Morinda officinalis, and Atractylodes macrocephala (OR range, 0.31-0.79). CONCLUSIONS: Consuming herbal soups including specific plants, but not herbal tea, was inversely associated with NPC. If replicated, these results might provide potential for NPC prevention in endemic areas.
Authors: S R Zhuang; H F Chiu; S L Chen; J H Tsai; M Y Lee; H S Lee; Y C Shen; Y Y Yan; G T Shane; C-K Wang Journal: Br J Nutr Date: 2011-08-25 Impact factor: 3.718
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