Literature DB >> 2753855

Methylation of 23S rRNA caused by tlrA (ermSF), a tylosin resistance determinant from Streptomyces fradiae.

M Zalacain1, E Cundliffe.   

Abstract

Ribosomes from Streptomyces griseofuscus expressing tlrA, a resistance gene isolated from the tylosin producer Streptomyces fradiae, are resistant to macrolide and lincosamide antibiotics in vitro. The tlrA product was found to be a methylase that introduces two methyl groups into a single base within 23S rRNA, generating N6,N6-dimethyladenine at position 2058. This activity is therefore similar to the ermE resistance mechanism in Saccharopolyspora erythraea (formerly Streptomyces erythraeus).

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Year:  1989        PMID： 2753855      PMCID： PMC210198          DOI： 10.1128/jb.171.8.4254-4260.1989

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  24 in total

1.  RNA molecular weight determinations by gel electrophoresis under denaturing conditions, a critical reexamination.

Authors:  H Lehrach; D Diamond; J M Wozney; H Boedtker
Journal:  Biochemistry       Date:  1977-10-18       Impact factor: 3.162

2.  Sites of action of two ribosomal RNA methylases responsible for resistance to aminoglycosides.

Authors:  A A Beauclerk; E Cundliffe
Journal:  J Mol Biol       Date:  1987-02-20       Impact factor: 5.469

3.  Structural analysis of RNA using chemical and enzymatic probing monitored by primer extension.

Authors:  S Stern; D Moazed; H F Noller
Journal:  Methods Enzymol       Date:  1988       Impact factor: 1.600

4.  Alteration of 23 S ribosomal RNA and erythromycin-induced resistance to lincomycin and spiramycin in Staphylococcus aureus.

Authors:  C J Lai; B Weisblum; S R Fahnestock; M Nomura
Journal:  J Mol Biol       Date:  1973-02-15       Impact factor: 5.469

5.  Reconstitution of 50 S ribosomal subunits from Bacillus stearothermophilus.

Authors:  S Fahnestock; V Erdmann; M Nomura
Journal:  Methods Enzymol       Date:  1974       Impact factor: 1.600

Review 6.  On the nature of antibiotic binding sites in ribosomes.

Authors:  E Cundliffe
Journal:  Biochimie       Date:  1987-08       Impact factor: 4.079

7.  Cloning and expression of a tylosin resistance gene from a tylosin-producing strain of Streptomyces fradiae.

Authors:  V A Birmingham; K L Cox; J L Larson; S E Fishman; C L Hershberger; E T Seno
Journal:  Mol Gen Genet       Date:  1986-09

8.  Use of a fractionated coupled transcription-translation system in the study of ribosomal resistance mechanisms in antibiotic-producing Streptomyces.

Authors:  M J Calcutt; E Cundliffe
Journal:  J Gen Microbiol       Date:  1989-05

9.  Cloning and analysis of the promoter region of the erythromycin resistance gene (ermE) of Streptomyces erythraeus.

Authors:  M J Bibb; G R Janssen; J M Ward
Journal:  Gene       Date:  1985       Impact factor: 3.688

10.  Translational attenuation control of ermSF, an inducible resistance determinant encoding rRNA N-methyltransferase from Streptomyces fradiae.

Authors:  S Kamimiya; B Weisblum
Journal:  J Bacteriol       Date:  1988-04       Impact factor: 3.490
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  23 in total

1.  Negative in vitro selection identifies the rRNA recognition motif for ErmE methyltransferase.

Authors:  A K Nielsen; S Douthwaite; B Vester
Journal:  RNA       Date:  1999-08       Impact factor: 4.942

Review 2.  Nomenclature for macrolide and macrolide-lincosamide-streptogramin B resistance determinants.

Authors:  M C Roberts; J Sutcliffe; P Courvalin; L B Jensen; J Rood; H Seppala
Journal:  Antimicrob Agents Chemother       Date:  1999-12       Impact factor: 5.191

3.  Role of glycosylation and deglycosylation in biosynthesis of and resistance to oleandomycin in the producer organism, Streptomyces antibioticus.

Authors:  C Vilches; C Hernandez; C Mendez; J A Salas
Journal:  J Bacteriol       Date:  1992-01       Impact factor: 3.490

Review 4.  Avoidance of suicide in antibiotic-producing microbes.

Authors:  Eric Cundliffe; Arnold L Demain
Journal:  J Ind Microbiol Biotechnol       Date:  2010-05-06       Impact factor: 3.346

5.  The Streptomyces peucetius drrC gene encodes a UvrA-like protein involved in daunorubicin resistance and production.

Authors:  N Lomovskaya; S K Hong; S U Kim; L Fonstein; K Furuya; R C Hutchinson
Journal:  J Bacteriol       Date:  1996-06       Impact factor: 3.490

6.  Resistance to the macrolide antibiotic tylosin is conferred by single methylations at 23S rRNA nucleotides G748 and A2058 acting in synergy.

Authors:  Mingfu Liu; Stephen Douthwaite
Journal:  Proc Natl Acad Sci U S A       Date:  2002-11-04       Impact factor: 11.205

7.  Domain V of 23S rRNA contains all the structural elements necessary for recognition by the ErmE methyltransferase.

Authors:  B Vester; S Douthwaite
Journal:  J Bacteriol       Date:  1994-11       Impact factor: 3.490

8.  23S rRNA domain V, a fragment that can be specifically methylated in vitro by the ErmSF (TlrA) methyltransferase.

Authors:  D Kovalic; R B Giannattasio; H J Jin; B Weisblum
Journal:  J Bacteriol       Date:  1994-11       Impact factor: 3.490

9.  The macrolide-lincosamide-streptogramin B resistance phenotypes characterized by using a specifically deleted, antibiotic-sensitive strain of Streptomyces lividans.

Authors:  J L Pernodet; S Fish; M H Blondelet-Rouault; E Cundliffe
Journal:  Antimicrob Agents Chemother       Date:  1996-03       Impact factor: 5.191

10.  Microbial conversion of avermectins by Saccharopolyspora erythraea: glycosylation at C-4' and C-4''.

Authors:  M Schulman; P Doherty; B Arison
Journal:  Antimicrob Agents Chemother       Date:  1993-09       Impact factor: 5.191
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