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Literature DB >> 8239577

Microbial conversion of avermectins by Saccharopolyspora erythraea: glycosylation at C-4' and C-4''.

Abstract

Avermectins and ivermectins are glycosylated at C-4'' and C-4' by both growing and resting cells of Saccharopolyspora erythraea. The reaction is catalyzed by a glycosyltransferase which is constitutive. The enzyme uses UDP-glucose as the glycosyl donor and avermectin or ivermectin mono- and disaccharides as acceptors. Avermectin and ivermectin aglycones and erythromycin A are not substrates for the enzyme.

Entities: Chemical Species

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Year: 1993 PMID： 8239577 PMCID： PMC188062 DOI： 10.1128/AAC.37.9.1737

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

22 in total

1. S-adenosylmethionine:erythromycin C O-methyltransferase.

Authors: J W Corcoran
Journal: Methods Enzymol Date: 1975 Impact factor: 1.600

2. Structure of a phosphorylated derivative of oleandomycin, obtained by reaction of oleandomycin with an extract of an erythromycin-resistant strain of Escherichia coli.

Authors: K O'Hara; T Kanda; M Kono
Journal: J Antibiot (Tokyo) Date: 1988-06 Impact factor: 2.649

3. Avermectins, new family of potent anthelmintic agents: isolation and chromatographic properties.

Authors: T W Miller; L Chaiet; D J Cole; L J Cole; J E Flor; R T Goegelman; V P Gullo; H Joshua; A J Kempf; W R Krellwitz; R L Monaghan; R E Ormond; K E Wilson; G Albers-Schönberg; I Putter
Journal: Antimicrob Agents Chemother Date: 1979-03 Impact factor: 5.191

4. Insecticidal activity of the anti-parasitic avermectins.

Authors: D A Ostlind; S Cifelli; R Lang
Journal: Vet Rec Date: 1979-08-25 Impact factor: 2.695

5. Microbial conversion of avermectins by Saccharopolyspora erythrea: hydroxylation at C28.

Authors: M Schulman; P Doherty; D Zink; B Arison
Journal: J Antibiot (Tokyo) Date: 1993-06 Impact factor: 2.649

Review 6. Translational attenuation: the regulation of bacterial resistance to the macrolide-lincosamide-streptogramin B antibiotics.

Authors: D Dubnau
Journal: CRC Crit Rev Biochem Date: 1984

Microbial conversion of avermectins by Saccharopolyspora erythraea: glycosylation at C-4' and C-4''.

1. S-adenosylmethionine:erythromycin C O-methyltransferase.

2. Structure of a phosphorylated derivative of oleandomycin, obtained by reaction of oleandomycin with an extract of an erythromycin-resistant strain of Escherichia coli.

3. Avermectins, new family of potent anthelmintic agents: isolation and chromatographic properties.

4. Insecticidal activity of the anti-parasitic avermectins.

5. Microbial conversion of avermectins by Saccharopolyspora erythrea: hydroxylation at C28.

Review 6. Translational attenuation: the regulation of bacterial resistance to the macrolide-lincosamide-streptogramin B antibiotics.

7. Site of action of a ribosomal RNA methylase responsible for resistance to erythromycin and other antibiotics.

8. Avermectins, new family of potent anthelmintic agents: efficacy of the B1a component.

9. Avermectins, new family of potent anthelmintic agents: producing organism and fermentation.

10. Demethylavermectins. Biosynthesis, isolation and characterization.

1. New tenvermectin analogs obtained by microbial conversion with Saccharopolyspora erythraea.

2. Inactivation of the macrolide antibiotics erythromycin, midecamycin, and rokitamycin by pathogenic Nocardia species.

3. Midecamycin Is Inactivated by Several Different Sugar Moieties at Its Inactivation Site.