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Literature DB >> 27517224

Early clinical experience with cimetidine in duodenal ulcer patients.

Abstract

Nineteen patients with duodenal ulcer have been treated with cimetidine 1.2 G daily for six weeks. All experienced striking symptomatic improvement. Measurement of gastric secretion showed that tolerance to cimetidine had not developed after six weeks treatment. No significant side effects were noted. Cimetidine appears to be a safe and effective means of controlling duodenal ulcer symptoms. Controlled trials are indicated.

Entities: Chemical Disease Species

Year: 1976 PMID： 27517224 DOI： 10.1007/BF02938940

Source DB: PubMed Journal: Ir J Med Sci ISSN： 0021-1265 Impact factor: 1.568

18 in total

1. Pharmacological evaluation of cimetidine, a new histamine H2-receptor antagonist, in healthy man.

Authors: W L Burland; W A Duncan; T Hesselbo; J G Mills; P C Sharpe; S J Haggie; J H Wyllie
Journal: Br J Clin Pharmacol Date: 1975-12 Impact factor: 4.335

2. Inhibition of nocturnal acid secretion in duodenal ulcer by one oral dose of metiamide.

Authors: G J Milton-Thompson; J G Williams; D J Jenkins; J J Misiewicz
Journal: Lancet Date: 1974-04-20 Impact factor: 79.321

3. Positioning of subject and of nasogastric tube during a gastric secretion study.

Authors: M A Hassan; M Hobsley
Journal: Br Med J Date: 1970-02-21

4. Metiamide in the Zollinger-Ellison syndrome.

Authors: E L Blair; E R Grund; I T Miller; J D Redd; D J Sanders; M H Thompson; C W Venables
Journal: Am J Dig Dis Date: 1975-12

5. Letter: Neutropenia associated with metiamide.

Authors: J A Forrest; D J Shearman; R Spence; L R Celestin
Journal: Lancet Date: 1975-02-15 Impact factor: 79.321

6. Metiamide, an H2-receptor blocker, as inhibitor of basal and meal-stimulated gastric acid secretion in patients with duodenal ulcer.

Authors: M Mainardi; V Maxwell; R A Sturdevant; J I Isenberg
Journal: N Engl J Med Date: 1974-08-22 Impact factor: 91.245

Early clinical experience with cimetidine in duodenal ulcer patients.

1. Pharmacological evaluation of cimetidine, a new histamine H2-receptor antagonist, in healthy man.

2. Inhibition of nocturnal acid secretion in duodenal ulcer by one oral dose of metiamide.

3. Positioning of subject and of nasogastric tube during a gastric secretion study.

4. Metiamide in the Zollinger-Ellison syndrome.

5. Letter: Neutropenia associated with metiamide.

6. Metiamide, an H2-receptor blocker, as inhibitor of basal and meal-stimulated gastric acid secretion in patients with duodenal ulcer.

7. Letter: Reversal of metiamide-induced agranulocytosis during treatment with cimetidine.

8. Relief of duodenal ulcer sysmptons by oral metiamide.

9. 24-hour control of intragastric acidity by cimetidine in duodenal-ulcer patients.

10. Effect of histamine H2-receptor blockade on vagally induced gastric secretion in man.

1. Role of cimetidine in relapse--prevention of duodenal ulcers healed by cimetidine.