| Literature DB >> 53554 |
R E Pounder, J G Williams, G J Milton-Thompson, J J Misiewicz.
Abstract
The effects of two dose regimens of cimetidine on 24 h intragastric acidity were investigated in six patients with duodenal ulcer. They received placebo capsules on the first day and cimetidine on the second day. Cimetidine 0-8 g/day decreased 24 h mean H+ activity by 55% but 1-6 g/day decreased it by 67%, the difference being due to a greater nocturnal decrease in the high-dose group. Intragastric pH remained below 2-0 for much of the treatment day but similar values were found in four post-vagotomy patients. Cimetidine 0-8-1-6 g/day results in a decrease of intragastric acidity that is compatible with successful medical treatment of duodenal ulceration.Entities:
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Year: 1975 PMID： 53554 DOI： 10.1016/s0140-6736(75)90434-1
Source DB: PubMed Journal: Lancet ISSN： 0140-6736 Impact factor: 79.321