Literature DB >> 4153330

Effect of histamine H2-receptor blockade on vagally induced gastric secretion in man.

D C Carter, J A Forrest, M Werner, R C Heading, J Park, D J Shearman.   

Abstract

Metiamide, an antagonist of histamine H(2) receptors, was administered intravenously to normal subjects and to patients with a peptic ulcer during vagal stimulation with a constant infusion of insulin. In normal and peptic-ulcer subjects there were reductions of 70% and 71% respectively in gastric-acid output compared with control tests on the same subjects. The decreased acid output resulted from a reduction in both volume of secretion and acid concentration. Metiamide is therefore a potent inhibitor of vagally-induced gastric acid secretion.

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Year:  1974        PMID： 4153330      PMCID： PMC1611532          DOI： 10.1136/bmj.3.5930.554

Source DB:  PubMed          Journal:  Br Med J        ISSN： 0007-1447


  4 in total

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Authors:  J W Black; W A Duncan; C J Durant; C R Ganellin; E M Parsons
Journal:  Nature       Date:  1972-04-21       Impact factor: 49.962

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Authors:  A S Ash; H O Schild
Journal:  Br J Pharmacol Chemother       Date:  1966-08

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Authors:  S J Konturek; J Oleksy; A Wysocki
Journal:  Am J Dig Dis       Date:  1968-09

4.  Positioning of subject and of nasogastric tube during a gastric secretion study.

Authors:  M A Hassan; M Hobsley
Journal:  Br Med J       Date:  1970-02-21
  4 in total
  10 in total

1.  Pharmacological evaluation of cimetidine, a new histamine H2-receptor antagonist, in healthy man.

Authors:  W L Burland; W A Duncan; T Hesselbo; J G Mills; P C Sharpe; S J Haggie; J H Wyllie
Journal:  Br J Clin Pharmacol       Date:  1975-12       Impact factor: 4.335

2.  Early clinical experience with metiamide, a histamine H2-receptor antagonist, in patients with duodenal ulcer.

Authors:  M H Thompson; J D Reed; G Dale; C W Venables
Journal:  Am J Dig Dis       Date:  1975-12

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Authors:  P E O'Brien; D C Carter
Journal:  Gut       Date:  1975-06       Impact factor: 23.059

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Authors:  R E Pounder; J G Williams; G J Milton-Thompson; J J Misiewicz
Journal:  Br Med J       Date:  1975-05-10

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Authors:  C G Clark; J H Wyllie
Journal:  World J Surg       Date:  1977-01       Impact factor: 3.352

6.  The effects of somatostatin and metiamide on tachyphylaxis of pentagastrin stimulated gastric acid and pepsin secretion in the conscious cat.

Authors:  M Albinus; E L Blair; B H Hirst; J D Reed; A V Schally; B Shaw
Journal:  J Physiol       Date:  1977-04       Impact factor: 5.182

7.  The interaction of histamine with gastrin and carbamylcholine on oxygen uptake by isolated mammalian parietal cells.

Authors:  A H Soll
Journal:  J Clin Invest       Date:  1978-02       Impact factor: 14.808

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Authors:  S C Bajaj; B I Hirschowitz
Journal:  Am J Dig Dis       Date:  1976-07

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Authors:  N S Broughton; J F Morris
Journal:  Br J Pharmacol       Date:  1982-08       Impact factor: 8.739

10.  Early clinical experience with cimetidine in duodenal ulcer patients.

Authors:  J F Groarke; O FitzGerald
Journal:  Ir J Med Sci       Date:  1976-12       Impact factor: 1.568
  10 in total

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