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Literature DB >> 1106187

Metiamide in the Zollinger-Ellison syndrome.

E L Blair, E R Grund, I T Miller, J D Redd, D J Sanders, M H Thompson, C W Venables.

Abstract

The histamine H2-receptor antagonist metiamide is an inhibitor of endogenous and stimulated gastric-acid secretion. It appears to have therapeutic possibilities in duodenal-ulcer disease. Three patients exhibiting the Zollinger-Ellison syndrome have been treated with this drug for six months or more. Rapid symptomatic improvement occurred in each case, followed by ulcer healing. There were also reductions in gastric secretion and consistent changes in the fasting serum-gastrin concentration. On patient relapsed temporarily during therapy. There have been no side effects. It is concluded that, in the short term, metiamide is of benefit in the Zollinger-Ellison syndrome.

Entities: Chemical Disease Gene Species

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Year: 1975 PMID： 1106187 DOI： 10.1007/bf01070755

Source DB: PubMed Journal: Am J Dig Dis ISSN： 0002-9211

15 in total

Metiamide in the Zollinger-Ellison syndrome.

1. Nutrition following total gastrectomy, with particular reference to fat and protein assimilation.

2. Definition and antagonism of histamine H 2 -receptors.

3. Inhibition of nocturnal acid secretion in duodenal ulcer by one oral dose of metiamide.

4. The effect of histamine (H2-) receptor blockade on vagally-induced gastric secretion in man.

5. Immunochemical studies with synthetic human gastrin.

6. Preparation of 125 I-labelled synthetic human gastrin I for radioimmunoanalysis.

7. The value of a combined pentagastrin-insulin test in studies of stomal ulceration.

8. Early clinical experience with metiamide, a histamine H2-receptor antagonist, in patients with duodenal ulcer.

9. Letter: Metiamide in Zollinger-Ellison syndrome.

10. Gastric response to metiamide.

1. Nocturnal metiamide treatment in the management of healed duodenal ulceration.

2. Histamine H2-receptor antagonists and gastric acid secretion -- a progress report.

3. Gastrointestinal ulceration in the guinea pig in response to dimaprit, histamine, and H1- and H2-blocking agents.

4. Results of surgical management in 92 consecutive patients with Zollinger-Ellison syndrome.

5. Early clinical experience with cimetidine in duodenal ulcer patients.