Xiaoyan Yu1,2,3, Lu Liu1,2,3, Wai Chen4,5, Qingjiu Cao1,2, Florian Daniel Zepf4,5, Gongjun Ji6, Zhaomin Wu1,2, Li An1,2, Peng Wang1,2, Qiujin Qian1,2, Yufeng Zang7, Li Sun1,2, Yufeng Wang1,2. 1. Peking University Sixth Hospital/Institute of Mental Health, Beijing, China. 2. National Clinical Research Center for Mental Disorders & Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing, China. 3. Joint first authors. 4. Centre & Discipline of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy; School of Psychiatry and Clinical Neurosciences & School of Paediatrics and Child Health, The University of Western Australia, Perth, WA, Australia. 5. Specialised Child and Adolescent Mental Health Services, Department of Health in Western Australia, Perth, WA, Australia. 6. Laboratory of Cognitive Neuropsychology, Department of Medical Psychology, Anhui Medical University, Hefei, China. 7. Center for Cognition and Brain Disorders and the Affiliated Hospital, Hangzhou Normal University; Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou, China.
Abstract
Objective: This study evaluated the functional networks of amygdala subregions (basolateral [BLA], centromedial [CMA], and superficial amygdala [SFA]) in ADHD and their association with emotional lability (EL) symptoms. Method: Resting-state functional connectivity (RSFC) of amygdala subregions and their correlations with EL scores were evaluated in 35 drug-naïve boys with ADHD and 30 age-matched healthy controls (HC). Results: Compared with HC, altered RSFC were detected differently for each amygdala subregion in ADHD: altered RSFC of BLA with the thalamus and vermis; aberrant RSFC of CMA with the superior temporal gyrus/pole and insula, precuneus and cerebellum; reduced RSFC of SFA with dorsal frontoparietal cortices. Within ADHD, higher EL scores were associated with reduced negative RSFC of SFA with the dorsolateral prefrontal cortex and inferior parietal lobe. Conclusion: Diffuse alterations of amygdala subregion-based networks are associated with ADHD, and the weaker SFA-frontoparietal networks might be involved in the hypothesized top-down effortful regulation of emotion.
Objective: This study evaluated the functional networks of amygdala subregions (basolateral [BLA], centromedial [CMA], and superficial amygdala [SFA]) in ADHD and their association with emotional lability (EL) symptoms. Method: Resting-state functional connectivity (RSFC) of amygdala subregions and their correlations with EL scores were evaluated in 35 drug-naïve boys with ADHD and 30 age-matched healthy controls (HC). Results: Compared with HC, altered RSFC were detected differently for each amygdala subregion in ADHD: altered RSFC of BLA with the thalamus and vermis; aberrant RSFC of CMA with the superior temporal gyrus/pole and insula, precuneus and cerebellum; reduced RSFC of SFA with dorsal frontoparietal cortices. Within ADHD, higher EL scores were associated with reduced negative RSFC of SFA with the dorsolateral prefrontal cortex and inferior parietal lobe. Conclusion: Diffuse alterations of amygdala subregion-based networks are associated with ADHD, and the weaker SFA-frontoparietal networks might be involved in the hypothesized top-down effortful regulation of emotion.
Authors: Martine Hoogman; Ryan Muetzel; Joao P Guimaraes; Elena Shumskaya; Maarten Mennes; Marcel P Zwiers; Neda Jahanshad; Gustavo Sudre; Thomas Wolfers; Eric A Earl; Juan Carlos Soliva Vila; Yolanda Vives-Gilabert; Sabin Khadka; Stephanie E Novotny; Catharina A Hartman; Dirk J Heslenfeld; Lizanne J S Schweren; Sara Ambrosino; Bob Oranje; Patrick de Zeeuw; Tiffany M Chaim-Avancini; Pedro G P Rosa; Marcus V Zanetti; Charles B Malpas; Gregor Kohls; Georg G von Polier; Jochen Seitz; Joseph Biederman; Alysa E Doyle; Anders M Dale; Theo G M van Erp; Jeffery N Epstein; Terry L Jernigan; Ramona Baur-Streubel; Georg C Ziegler; Kathrin C Zierhut; Anouk Schrantee; Marie F Høvik; Astri J Lundervold; Clare Kelly; Hazel McCarthy; Norbert Skokauskas; Ruth L O'Gorman Tuura; Anna Calvo; Sara Lera-Miguel; Rosa Nicolau; Kaylita C Chantiluke; Anastasia Christakou; Alasdair Vance; Mara Cercignani; Matt C Gabel; Philip Asherson; Sarah Baumeister; Daniel Brandeis; Sarah Hohmann; Ivanei E Bramati; Fernanda Tovar-Moll; Andreas J Fallgatter; Bernd Kardatzki; Lena Schwarz; Anatoly Anikin; Alexandr Baranov; Tinatin Gogberashvili; Dmitry Kapilushniy; Anastasia Solovieva; Hanan El Marroun; Tonya White; Georgii Karkashadze; Leyla Namazova-Baranova; Thomas Ethofer; Paulo Mattos; Tobias Banaschewski; David Coghill; Kerstin J Plessen; Jonna Kuntsi; Mitul A Mehta; Yannis Paloyelis; Neil A Harrison; Mark A Bellgrove; Tim J Silk; Ana I Cubillo; Katya Rubia; Luisa Lazaro; Silvia Brem; Susanne Walitza; Thomas Frodl; Mariam Zentis; Francisco X Castellanos; Yuliya N Yoncheva; Jan Haavik; Liesbeth Reneman; Annette Conzelmann; Klaus-Peter Lesch; Paul Pauli; Andreas Reif; Leanne Tamm; Kerstin Konrad; Eileen Oberwelland Weiss; Geraldo F Busatto; Mario R Louza; Sarah Durston; Pieter J Hoekstra; Jaap Oosterlaan; Michael C Stevens; J Antoni Ramos-Quiroga; Oscar Vilarroya; Damien A Fair; Joel T Nigg; Paul M Thompson; Jan K Buitelaar; Stephen V Faraone; Philip Shaw; Henning Tiemeier; Janita Bralten; Barbara Franke Journal: Am J Psychiatry Date: 2019-04-24 Impact factor: 18.112
Authors: Prerona Mukherjee; Veronika Vilgis; Shawn Rhoads; Rajpreet Chahal; Catherine Fassbender; Ellen Leibenluft; J Faye Dixon; Murat Pakyurek; Wouter van den Bos; Stephen P Hinshaw; Amanda E Guyer; Julie B Schweitzer Journal: J Atten Disord Date: 2021-11-02 Impact factor: 3.256
Authors: Tammo Viering; Pieter J Hoekstra; Alexandra Philipsen; Jilly Naaijen; Andrea Dietrich; Catharina A Hartman; Jan K Buitelaar; Andrea Hildebrandt; Carsten Gießing; Christiane M Thiel Journal: Sci Rep Date: 2021-07-22 Impact factor: 4.379