Literature DB >> 27466037

Prenatal genetic counselling for psychiatric disorders.

Angela Inglis1,2, Emily Morris1,2, Jehannine Austin1,2.   

Abstract

Psychiatric disorders like schizophrenia, bipolar disorder, depression, anxiety, and obsessive-compulsive disorder are common disorders with complex aetiology. They can exact a heavy toll on the individual with the condition and can have significant impact on family members too. Accordingly, psychiatric disorders can arise as a concern in the prenatal context - couples may be interested in learning about the chance for their child to develop the illness that manifests in the family and may be interested in discussing options for prenatal testing. However, the complex nature of these conditions can present challenges for clinicians who seek to help families with these issues. We established the world's first specialist genetic counselling service of its kind in Vancouver, Canada, in 2012, and to date, have provided counselling for ~500 families and have demonstrated increases in patients' empowerment and self efficacy after genetic counselling. We draw on our accumulated clinical experience to outline the process by which we approach prenatal genetic counselling for psychiatric disorders to assist other clinicians in providing thoughtful, comprehensive support to couples seeking out this service.
© 2016 John Wiley & Sons, Ltd. © 2016 John Wiley & Sons, Ltd.

Entities:  

Mesh:

Year:  2016        PMID: 27466037      PMCID: PMC5247258          DOI: 10.1002/pd.4878

Source DB:  PubMed          Journal:  Prenat Diagn        ISSN: 0197-3851            Impact factor:   3.050


  65 in total

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2.  The Schizophrenia Polygenic Risk Score: To What Does It Predispose in Adolescence?

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3.  High frequencies of de novo CNVs in bipolar disorder and schizophrenia.

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Journal:  Neuron       Date:  2011-12-22       Impact factor: 17.173

4.  Attitudes of medical genetics practitioners and psychiatrists toward communicating with patients about genetic risk for psychiatric disorders.

Authors:  Yi Zhou Zhou; Alex Wilde; Bettina Meiser; Philip B Mitchell; Kristine Barlow-Stewart; Peter R Schofield
Journal:  Psychiatr Genet       Date:  2014-06       Impact factor: 2.458

5.  The Genetic Counseling Outcome Scale: a new patient-reported outcome measure for clinical genetics services.

Authors:  M McAllister; A M Wood; G Dunn; S Shiloh; C Todd
Journal:  Clin Genet       Date:  2011-02-14       Impact factor: 4.438

Review 6.  Consensus statement: chromosomal microarray is a first-tier clinical diagnostic test for individuals with developmental disabilities or congenital anomalies.

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Journal:  Am J Hum Genet       Date:  2010-05-14       Impact factor: 11.025

7.  Familiality of the puerperal trigger in bipolar disorder: results of a family study.

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Journal:  Am J Psychiatry       Date:  2001-06       Impact factor: 18.112

8.  Models for the joint effect of genotype and environment on liability to psychiatric illness.

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Review 9.  Economic impact of early detection and early intervention of psychosis.

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10.  Mood disorders and parity - a clue to the aetiology of the postpartum trigger.

Authors:  Arianna Di Florio; Lisa Jones; Liz Forty; Katherine Gordon-Smith; Emma Robertson Blackmore; Jess Heron; Nick Craddock; Ian Jones
Journal:  J Affect Disord       Date:  2014-01       Impact factor: 4.839

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  6 in total

1.  Views of the importance of psychiatric genetic research by potential volunteers from stakeholder groups.

Authors:  Laura Weiss Roberts; Tenzin Tsungmey; Jane Paik Kim; Melinda Hantke
Journal:  J Psychiatr Res       Date:  2018-09-19       Impact factor: 4.791

Review 2.  Clinical evaluation of patients with a neuropsychiatric risk copy number variant.

Authors:  Samuel Jra Chawner; Cameron J Watson; Michael J Owen
Journal:  Curr Opin Genet Dev       Date:  2021-01-15       Impact factor: 4.665

3.  Genetics and genetic counseling in psychiatry: Results from an opinion survey of professionals and users.

Authors:  Lourdes Martorell; Annabel Sanfeliu; Ana Blázquez; Elia Lojo; Maria José Cortés; Joan de Pablo; Elisabet Vilella
Journal:  Mol Genet Genomic Med       Date:  2019-06-29       Impact factor: 2.183

4.  Perceptions of causal attribution and attitudes to genetic testing among people with schizophrenia and their first-degree relatives.

Authors:  Melissa B R Cullen; Bettina Meiser; Kristine Barlow-Stewart; Melissa Green; Paul S Appelbaum; Vaughan J Carr; Murray J Cairns; M S Lebowitz; Rajneesh Kaur
Journal:  Eur J Hum Genet       Date:  2022-05-16       Impact factor: 5.351

5.  A cross-sectional study of the relationship between CYP2D6 and CYP2C19 variations and depression symptoms, for women taking SSRIs during pregnancy.

Authors:  Catriona Hippman; Caitlin Slomp; Emily Morris; Rolan Batallones; Angela Inglis; Prescilla Carrion; Ursula Brain; Michelle Higginson; Galen E B Wright; Lynda G Balneaves; Deirdre Ryan; Corey Nislow; Colin J D Ross; Andrea Gaedigk; Tim F Oberlander; Jehannine Austin
Journal:  Arch Womens Ment Health       Date:  2021-07-07       Impact factor: 3.633

Review 6.  Evidence-Based Genetic Counseling for Psychiatric Disorders: A Road Map.

Authors:  Jehannine C Austin
Journal:  Cold Spring Harb Perspect Med       Date:  2020-06-01       Impact factor: 5.159

  6 in total

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