Sean M Hamlet1,2, Christopher M Haggerty2,3, Jonathan D Suever2,3, Gregory J Wehner2,4, Kristin N Andres2, David K Powell4, Xiaodong Zhong5, Brandon K Fornwalt2,3,4,6,7. 1. Department of Electrical and Computer Engineering, University of Kentucky, Lexington, Kentucky, USA. 2. Department of Pediatrics, University of Kentucky, Lexington, KY, USA. 3. Institute for Advanced Application, Geisinger Health System, Danville, Pennsylvania, USA. 4. Department of Biomedical Engineering, University of Kentucky, Lexington, Kentucky, USA. 5. MR R&D Collaborations, Siemens Healthcare, Atlanta, GA, USA. 6. Department of Physiology, University of Kentucky, Lexington, Kentucky, USA. 7. Department of Medicine, University of Kentucky, Lexington, Kentucky, USA.
Abstract
PURPOSE: To determine the optimal respiratory navigator gating configuration for the quantification of left ventricular strain using spiral cine displacement encoding with stimulated echoes (DENSE) MRI. MATERIALS AND METHODS: Two-dimensional spiral cine DENSE was performed on a 3 Tesla MRI using two single-navigator configurations (retrospective, prospective) and a combined "dual-navigator" configuration in 10 healthy adults and 20 healthy children. The adults also underwent breathhold DENSE as a reference standard for comparisons. Peak left ventricular strains, signal-to-noise ratio (SNR), and navigator efficiency were compared. Subjects also underwent dual-navigator gating with and without visual feedback to determine the effect on navigator efficiency. RESULTS: There were no differences in circumferential, radial, and longitudinal strains between navigator-gated and breathhold DENSE (P = 0.09-0.95) (as confidence intervals, retrospective: [-1.0%-1.1%], [-7.4%-2.0%], [-1.0%-1.2%]; prospective: [-0.6%-2.7%], [-2.8%-8.3%], [-0.3%-2.9%]; dual: [-1.6%-0.5%], [-8.3%-3.2%], [-0.8%-1.9%], respectively). The dual configuration maintained SNR compared with breathhold acquisitions (16 versus 18, P = 0.06). SNR for the prospective configuration was lower than for the dual navigator in adults (P = 0.004) and children (P < 0.001). Navigator efficiency was higher (P < 0.001) for both retrospective (54%) and prospective (56%) configurations compared with the dual configuration (35%). Visual feedback improved the dual configuration navigator efficiency to 55% (P < 0.001). CONCLUSION: When quantifying left ventricular strains using spiral cine DENSE MRI, a dual navigator configuration results in the highest SNR in adults and children. In adults, a retrospective configuration has good navigator efficiency without a substantial drop in SNR. Prospective gating should be avoided because it has the lowest SNR. Visual feedback represents an effective option to maintain navigator efficiency while using a dual navigator configuration. LEVEL OF EVIDENCE: 2 J. Magn. Reson. Imaging 2017;45:786-794.
PURPOSE: To determine the optimal respiratory navigator gating configuration for the quantification of left ventricular strain using spiral cine displacement encoding with stimulated echoes (DENSE) MRI. MATERIALS AND METHODS: Two-dimensional spiral cine DENSE was performed on a 3 Tesla MRI using two single-navigator configurations (retrospective, prospective) and a combined "dual-navigator" configuration in 10 healthy adults and 20 healthy children. The adults also underwent breathhold DENSE as a reference standard for comparisons. Peak left ventricular strains, signal-to-noise ratio (SNR), and navigator efficiency were compared. Subjects also underwent dual-navigator gating with and without visual feedback to determine the effect on navigator efficiency. RESULTS: There were no differences in circumferential, radial, and longitudinal strains between navigator-gated and breathhold DENSE (P = 0.09-0.95) (as confidence intervals, retrospective: [-1.0%-1.1%], [-7.4%-2.0%], [-1.0%-1.2%]; prospective: [-0.6%-2.7%], [-2.8%-8.3%], [-0.3%-2.9%]; dual: [-1.6%-0.5%], [-8.3%-3.2%], [-0.8%-1.9%], respectively). The dual configuration maintained SNR compared with breathhold acquisitions (16 versus 18, P = 0.06). SNR for the prospective configuration was lower than for the dual navigator in adults (P = 0.004) and children (P < 0.001). Navigator efficiency was higher (P < 0.001) for both retrospective (54%) and prospective (56%) configurations compared with the dual configuration (35%). Visual feedback improved the dual configuration navigator efficiency to 55% (P < 0.001). CONCLUSION: When quantifying left ventricular strains using spiral cine DENSE MRI, a dual navigator configuration results in the highest SNR in adults and children. In adults, a retrospective configuration has good navigator efficiency without a substantial drop in SNR. Prospective gating should be avoided because it has the lowest SNR. Visual feedback represents an effective option to maintain navigator efficiency while using a dual navigator configuration. LEVEL OF EVIDENCE: 2 J. Magn. Reson. Imaging 2017;45:786-794.
Authors: Khaled Z Abd-Elmoniem; Chika C Obele; Christopher T Sibley; Jatin R Matta; Roderic I Pettigrew; Ahmed M Gharib Journal: J Comput Assist Tomogr Date: 2011 May-Jun Impact factor: 1.826
Authors: Daniel A Auger; Xiaodong Zhong; Frederick H Epstein; Bruce S Spottiswoode Journal: J Cardiovasc Magn Reson Date: 2012-01-11 Impact factor: 5.364
Authors: Sean M Hamlet; Christopher M Haggerty; Jonathan D Suever; Gregory J Wehner; Jonathan D Grabau; Kristin N Andres; Moriel H Vandsburger; David K Powell; Vincent L Sorrell; Brandon K Fornwalt Journal: J Cardiovasc Magn Reson Date: 2016-09-06 Impact factor: 5.364
Authors: Johannes T Kowallick; Pablo Lamata; Shazia T Hussain; Shelby Kutty; Michael Steinmetz; Jan M Sohns; Martin Fasshauer; Wieland Staab; Christina Unterberg-Buchwald; Boris Bigalke; Joachim Lotz; Gerd Hasenfuß; Andreas Schuster Journal: PLoS One Date: 2014-10-06 Impact factor: 3.240
Authors: Sean M Hamlet; Christopher M Haggerty; Jonathan D Suever; Gregory J Wehner; Jonathan D Grabau; Kristin N Andres; Moriel H Vandsburger; David K Powell; Vincent L Sorrell; Brandon K Fornwalt Journal: J Cardiovasc Magn Reson Date: 2016-09-06 Impact factor: 5.364