| Literature DB >> 27432226 |
Siddhartha P Kar1, Jonathan Beesley2, Ali Amin Al Olama3, Kyriaki Michailidou3, Jonathan Tyrer4, ZSofia Kote-Jarai5, Kate Lawrenson6, Sara Lindstrom7, Susan J Ramus6, Deborah J Thompson3, Adam S Kibel8, Agnieszka Dansonka-Mieszkowska9, Agnieszka Michael10, Aida K Dieffenbach11, Aleksandra Gentry-Maharaj12, Alice S Whittemore13, Alicja Wolk14, Alvaro Monteiro15, Ana Peixoto16, Andrzej Kierzek10, Angela Cox17, Anja Rudolph18, Anna Gonzalez-Neira19, Anna H Wu6, Annika Lindblom20, Anthony Swerdlow21, Argyrios Ziogas22, Arif B Ekici23, Barbara Burwinkel24, Beth Y Karlan25, Børge G Nordestgaard26, Carl Blomqvist27, Catherine Phelan15, Catriona McLean28, Celeste Leigh Pearce29, Celine Vachon30, Cezary Cybulski31, Chavdar Slavov32, Christa Stegmaier33, Christiane Maier34, Christine B Ambrosone35, Claus K Høgdall36, Craig C Teerlink37, Daehee Kang38, Daniel C Tessier39, Daniel J Schaid40, Daniel O Stram6, Daniel W Cramer41, David E Neal42, Diana Eccles43, Dieter Flesch-Janys44, Digna R Velez Edwards45, Dominika Wokozorczyk31, Douglas A Levine46, Drakoulis Yannoukakos47, Elinor J Sawyer48, Elisa V Bandera49, Elizabeth M Poole50, Ellen L Goode30, Elza Khusnutdinova51, Estrid Høgdall52, Fengju Song53, Fiona Bruinsma54, Florian Heitz55, Francesmary Modugno56, Freddie C Hamdy57, Fredrik Wiklund58, Graham G Giles59, Håkan Olsson60, Hans Wildiers61, Hans-Ulrich Ulmer62, Hardev Pandha10, Harvey A Risch63, Hatef Darabi58, Helga B Salvesen64, Heli Nevanlinna65, Henrik Gronberg58, Hermann Brenner66, Hiltrud Brauch67, Hoda Anton-Culver22, Honglin Song4, Hui-Yi Lim68, Iain McNeish69, Ian Campbell70, Ignace Vergote71, Jacek Gronwald31, Jan Lubiński31, Janet L Stanford72, Javier Benítez19, Jennifer A Doherty73, Jennifer B Permuth15, Jenny Chang-Claude18, Jenny L Donovan74, Joe Dennis3, Joellen M Schildkraut75, Johanna Schleutker76, John L Hopper77, Jolanta Kupryjanczyk9, Jong Y Park15, Jonine Figueroa78, Judith A Clements79, Julia A Knight80, Julian Peto81, Julie M Cunningham82, Julio Pow-Sang15, Jyotsna Batra79, Kamila Czene58, Karen H Lu83, Kathleen Herkommer84, Kay-Tee Khaw85, Keitaro Matsuo86, Kenneth Muir87, Kenneth Offitt88, Kexin Chen53, Kirsten B Moysich89, Kristiina Aittomäki90, Kunle Odunsi91, Lambertus A Kiemeney92, Leon F A G Massuger93, Liesel M Fitzgerald54, Linda S Cook94, Lisa Cannon-Albright95, Maartje J Hooning96, Malcolm C Pike97, Manjeet K Bolla3, Manuel Luedeke34, Manuel R Teixeira98, Marc T Goodman99, Marjanka K Schmidt100, Marjorie Riggan101, Markus Aly102, Mary Anne Rossing72, Matthias W Beckmann103, Matthieu Moisse104, Maureen Sanderson105, Melissa C Southey106, Michael Jones107, Michael Lush3, Michelle A T Hildebrandt108, Ming-Feng Hou109, Minouk J Schoemaker107, Montserrat Garcia-Closas110, Natalia Bogdanova111, Nazneen Rahman112, Nhu D Le113, Nick Orr114, Nicolas Wentzensen78, Nora Pashayan115, Paolo Peterlongo116, Pascal Guénel117, Paul Brennan118, Paula Paulo16, Penelope M Webb119, Per Broberg120, Peter A Fasching103, Peter Devilee121, Qin Wang3, Qiuyin Cai122, Qiyuan Li123, Radka Kaneva124, Ralf Butzow125, Reidun Kristin Kopperud64, Rita K Schmutzler126, Robert A Stephenson127, Robert J MacInnis128, Robert N Hoover78, Robert Winqvist129, Roberta Ness130, Roger L Milne128, Ruth C Travis131, Sara Benlloch3, Sara H Olson97, Shannon K McDonnell40, Shelley S Tworoger50, Sofia Maia16, Sonja Berndt78, Soo Chin Lee132, Soo-Hwang Teo133, Stephen N Thibodeau40, Stig E Bojesen134, Susan M Gapstur135, Susanne Krüger Kjær136, Tanja Pejovic137, Teuvo L J Tammela138, Thilo Dörk139, Thomas Brüning140, Tiina Wahlfors141, Tim J Key131, Todd L Edwards142, Usha Menon12, Ute Hamann62, Vanio Mitev124, Veli-Matti Kosma143, Veronica Wendy Setiawan6, Vessela Kristensen144, Volker Arndt145, Walther Vogel146, Wei Zheng122, Weiva Sieh13, William J Blot147, Wojciech Kluzniak31, Xiao-Ou Shu122, Yu-Tang Gao148, Fredrick Schumacher6, Matthew L Freedman149, Andrew Berchuck101, Alison M Dunning4, Jacques Simard150, Christopher A Haiman6, Amanda Spurdle151, Thomas A Sellers15, David J Hunter7, Brian E Henderson6, Peter Kraft7, Stephen J Chanock78, Fergus J Couch82, Per Hall58, Simon A Gayther6, Douglas F Easton152, Georgia Chenevix-Trench2, Rosalind Eeles153, Paul D P Pharoah152, Diether Lambrechts104.
Abstract
UNLABELLED: Breast, ovarian, and prostate cancers are hormone-related and may have a shared genetic basis, but this has not been investigated systematically by genome-wide association (GWA) studies. Meta-analyses combining the largest GWA meta-analysis data sets for these cancers totaling 112,349 cases and 116,421 controls of European ancestry, all together and in pairs, identified at P < 10(-8) seven new cross-cancer loci: three associated with susceptibility to all three cancers (rs17041869/2q13/BCL2L11; rs7937840/11q12/INCENP; rs1469713/19p13/GATAD2A), two breast and ovarian cancer risk loci (rs200182588/9q31/SMC2; rs8037137/15q26/RCCD1), and two breast and prostate cancer risk loci (rs5013329/1p34/NSUN4; rs9375701/6q23/L3MBTL3). Index variants in five additional regions previously associated with only one cancer also showed clear association with a second cancer type. Cell-type-specific expression quantitative trait locus and enhancer-gene interaction annotations suggested target genes with potential cross-cancer roles at the new loci. Pathway analysis revealed significant enrichment of death receptor signaling genes near loci with P < 10(-5) in the three-cancer meta-analysis. SIGNIFICANCE: We demonstrate that combining large-scale GWA meta-analysis findings across cancer types can identify completely new risk loci common to breast, ovarian, and prostate cancers. We show that the identification of such cross-cancer risk loci has the potential to shed new light on the shared biology underlying these hormone-related cancers. Cancer Discov; 6(9); 1052-67. ©2016 AACR.This article is highlighted in the In This Issue feature, p. 932. ©2016 American Association for Cancer Research.Entities:
Mesh：
Year: 2016 PMID： 27432226 PMCID： PMC5010513 DOI： 10.1158/2159-8290.CD-15-1227
Source DB: PubMed Journal: Cancer Discov ISSN： 2159-8274 Impact factor: 39.397