| Literature DB >> 28346442 |
Catherine M Phelan1,2, Karoline B Kuchenbaecker3,4, Jonathan P Tyrer5, Siddhartha P Kar5, Kate Lawrenson6, Stacey J Winham7, Joe Dennis5, Ailith Pirie5, Marjorie J Riggan8, Ganna Chornokur1, Madalene A Earp9, Paulo C Lyra1, Janet M Lee10, Simon Coetzee10, Jonathan Beesley11, Lesley McGuffog12, Penny Soucy13, Ed Dicks5, Andrew Lee12, Daniel Barrowdale12, Julie Lecarpentier12, Goska Leslie12, Cora M Aalfs14, Katja K H Aben15,16, Marcia Adams17, Julian Adlard18, Irene L Andrulis19,20, Hoda Anton-Culver21,22, Natalia Antonenkova23, Gerasimos Aravantinos24, Norbert Arnold25, Banu K Arun26, Brita Arver27, Jacopo Azzollini28, Judith Balmaña29, Susana N Banerjee30, Laure Barjhoux31, Rosa B Barkardottir32,33, Yukie Bean34,35, Matthias W Beckmann36, Alicia Beeghly-Fadiel37,38,39,40, Javier Benitez41,42, Marina Bermisheva43, Marcus Q Bernardini44, Michael J Birrer45, Line Bjorge46,47, Amanda Black48, Kenneth Blankstein49, Marinus J Blok50, Clara Bodelon48, Natalia Bogdanova51, Anders Bojesen52, Bernardo Bonanni53, Åke Borg54, Angela R Bradbury55, James D Brenton56, Carole Brewer57, Louise Brinton48, Per Broberg58, Angela Brooks-Wilson59, Fiona Bruinsma60, Joan Brunet61, Bruno Buecher62, Ralf Butzow63, Saundra S Buys64, Trinidad Caldes65, Maria A Caligo66, Ian Campbell67,68, Rikki Cannioto69, Michael E Carney70, Terence Cescon49, Salina B Chan71, Jenny Chang-Claude72,73, Stephen Chanock48, Xiao Qing Chen11, Yoke-Eng Chiew74,75, Jocelyne Chiquette76, Wendy K Chung77, Kathleen B M Claes78, Thomas Conner64, Linda S Cook79, Jackie Cook80, Daniel W Cramer81, Julie M Cunningham82, Aimee A D'Aloisio83, Mary B Daly84, Francesca Damiola31, Sakaeva Dina Damirovna85, Agnieszka Dansonka-Mieszkowska86, Fanny Dao87, Rosemarie Davidson88, Anna DeFazio74,75, Capucine Delnatte89, Kimberly F Doheny17, Orland Diez90,91, Yuan Chun Ding92, Jennifer Anne Doherty93, Susan M Domchek55, Cecilia M Dorfling94, Thilo Dörk95, Laure Dossus96, Mercedes Duran97, Matthias Dürst98, Bernd Dworniczak99, Diana Eccles100, Todd Edwards37,38,39,40, Ros Eeles101, Ursula Eilber72, Bent Ejlertsen102, Arif B Ekici103, Steve Ellis12, Mingajeva Elvira85, Kevin H Eng104, Christoph Engel105, D Gareth Evans106, Peter A Fasching36,107, Sarah Ferguson44, Sandra Fert Ferrer108, James M Flanagan109, Zachary C Fogarty7, Renée T Fortner72, Florentia Fostira110, William D Foulkes111, George Fountzilas112, Brooke L Fridley113, Tara M Friebel114, Eitan Friedman115,116, Debra Frost12, Patricia A Ganz117, Judy Garber118, María J García41,42, Vanesa Garcia-Barberan65, Andrea Gehrig119, Aleksandra Gentry-Maharaj120, Anne-Marie Gerdes121, Graham G Giles60,122,123, Rosalind Glasspool124, Gord Glendon125, Andrew K Godwin126, David E Goldgar127, Teodora Goranova56, Martin Gore128, Mark H Greene129, Jacek Gronwald130, Stephen Gruber131, Eric Hahnen132, Christopher A Haiman133, Niclas Håkansson134, Ute Hamann135, Thomas V O Hansen136, Patricia A Harrington5, Holly R Harris134, Jan Hauke132, Alexander Hein36, Alex Henderson137, Michelle A T Hildebrandt138, Peter Hillemanns139, Shirley Hodgson140, Claus K Høgdall141, Estrid Høgdall142,143, Frans B L Hogervorst144, Helene Holland11, Maartje J Hooning145, Karen Hosking5, Ruea-Yea Huang146, Peter J Hulick147, Jillian Hung74,75, David J Hunter148, David G Huntsman149,150, Tomasz Huzarski130, Evgeny N Imyanitov151, Claudine Isaacs152, Edwin S Iversen153, Louise Izatt154, Angel Izquierdo61, Anna Jakubowska130, Paul James155,156, Ramunas Janavicius157,158, Mats Jernetz159, Allan Jensen142, Uffe Birk Jensen160, Esther M John161, Sharon Johnatty11, Michael E Jones162, Päivi Kannisto159, Beth Y Karlan6, Anthony Karnezis149,150, Karin Kast163, Catherine J Kennedy74,75, Elza Khusnutdinova43, Lambertus A Kiemeney15, Johanna I Kiiski164, Sung-Won Kim165, Susanne K Kjaer141,142, Martin Köbel166, Reidun K Kopperud46,47, Torben A Kruse167, Jolanta Kupryjanczyk86, Ava Kwong168,169,170, Yael Laitman115,116, Diether Lambrechts171,172, Nerea Larrañaga173,174, Melissa C Larson7, Conxi Lazaro175, Nhu D Le176, Loic Le Marchand177, Jong Won Lee178, Shashikant B Lele179, Arto Leminen164, Dominique Leroux180, Jenny Lester6, Fabienne Lesueur181,182, Douglas A Levine87, Dong Liang183, Clemens Liebrich184, Jenna Lilyquist185, Loren Lipworth37,38,40, Jolanta Lissowska186, Karen H Lu187, Jan Lubinński130, Craig Luccarini5, Lene Lundvall188, Phuong L Mai129, Gustavo Mendoza-Fandiño1, Siranoush Manoukian28, Leon F A G Massuger15, Taymaa May44, Sylvie Mazoyer189, Jessica N McAlpine190, Valerie McGuire191, John R McLaughlin192, Iain McNeish193, Hanne Meijers-Heijboer194, Alfons Meindl195, Usha Menon120, Arjen R Mensenkamp196, Melissa A Merritt197, Roger L Milne60,122, Gillian Mitchell155,156, Francesmary Modugno198,199,200, Joanna Moes-Sosnowska86, Melissa Moffitt35,201, Marco Montagna202, Kirsten B Moysich69, Anna Marie Mulligan20,203, Jacob Musinsky204, Katherine L Nathanson55, Lotte Nedergaard205, Roberta B Ness206, Susan L Neuhausen92, Heli Nevanlinna164, Dieter Niederacher207, Robert L Nussbaum208,209, Kunle Odunsi179, Edith Olah210, Olufunmilayo I Olopade211, Håkan Olsson58,212, Curtis Olswold185, David M O'Malley213, Kai-Ren Ong214, N Charlotte Onland-Moret215, Nicholas Orr216, Sandra Orsulic6, Ana Osorio41, Domenico Palli217, Laura Papi218, Tjoung-Won Park-Simon139, James Paul219, Celeste L Pearce133,220, Inge Søkilde Pedersen221, Petra H M Peeters215, Bernard Peissel28, Ana Peixoto222, Tanja Pejovic35,201, Liisa M Pelttari164, Jennifer B Permuth1, Paolo Peterlongo223, Lidia Pezzani28, Georg Pfeiler224, Kelly-Anne Phillips122,156,225, Marion Piedmonte226, Malcolm C Pike133,227, Anna M Piskorz56, Samantha R Poblete179, Timea Pocza210, Elizabeth M Poole228, Bruce Poppe78, Mary E Porteous229, Fabienne Prieur230, Darya Prokofyeva85, Elizabeth Pugh17, Miquel Angel Pujana231, Pascal Pujol232, Paolo Radice233, Johanna Rantala234, Christine Rappaport-Fuerhauser224, Gad Rennert235,236, Kerstin Rhiem132, Patricia Rice49, Andrea Richardson237, Mark Robson238, Gustavo C Rodriguez239, Cristina Rodríguez-Antona42,240, Jane Romm17, Matti A Rookus241, Mary Anne Rossing242, Joseph H Rothstein191, Anja Rudolph72, Ingo B Runnebaum98, Helga B Salvesen46,47, Dale P Sandler243, Minouk J Schoemaker162, Leigha Senter244, V Wendy Setiawan133, Gianluca Severi245,246,247,248, Priyanka Sharma249, Tameka Shelford17, Nadeem Siddiqui250, Lucy E Side251, Weiva Sieh191, Christian F Singer224, Hagay Sobol252, Honglin Song5, Melissa C Southey253, Amanda B Spurdle11, Zsofia Stadler238, Doris Steinemann254, Dominique Stoppa-Lyonnet62, Lara E Sucheston-Campbell255, Grzegorz Sukiennicki130, Rebecca Sutphen256, Christian Sutter257, Anthony J Swerdlow162,258, Csilla I Szabo259, Lukasz Szafron86, Yen Y Tan224, Jack A Taylor243, Muy-Kheng Tea224, Manuel R Teixeira222,260, Soo-Hwang Teo261,262, Kathryn L Terry81,263, Pamela J Thompson264, Liv Cecilie Vestrheim Thomsen46,47, Darcy L Thull265, Laima Tihomirova266, Anna V Tinker267, Marc Tischkowitz111,268, Silvia Tognazzo202, Amanda Ewart Toland269, Alicia Tone44, Britton Trabert48, Ruth C Travis270, Antonia Trichopoulou271,272, Nadine Tung273, Shelley S Tworoger228,263, Anne M van Altena274, David Van Den Berg133, Annemarie H van der Hout275, Rob B van der Luijt276, Mattias Van Heetvelde78, Els Van Nieuwenhuysen277, Elizabeth J van Rensburg94, Adriaan Vanderstichele277, Raymonda Varon-Mateeva278, Ana Vega279,280, Digna Velez Edwards38,40,281, Ignace Vergote277, Robert A Vierkant7, Joseph Vijai204, Athanassios Vratimos110, Lisa Walker282, Christine Walsh6, Dorothea Wand283, Shan Wang-Gohrke284, Barbara Wappenschmidt132, Penelope M Webb285, Clarice R Weinberg286, Jeffrey N Weitzel287, Nicolas Wentzensen48, Alice S Whittemore191,288, Juul T Wijnen289, Lynne R Wilkens177, Alicja Wolk134, Michelle Woo149,150, Xifeng Wu138, Anna H Wu133, Hannah Yang48, Drakoulis Yannoukakos110, Argyrios Ziogas22, Kristin K Zorn265, Steven A Narod290, Douglas F Easton4,5, Christopher I Amos291, Joellen M Schildkraut292, Susan J Ramus293,294, Laura Ottini295, Marc T Goodman264,296, Sue K Park297,298,299, Linda E Kelemen300, Harvey A Risch301, Mads Thomassen167, Kenneth Offit204, Jacques Simard13, Rita Katharina Schmutzler132, Dennis Hazelett302, Alvaro N Monteiro1, Fergus J Couch82, Andrew Berchuck8, Georgia Chenevix-Trench11, Ellen L Goode9, Thomas A Sellers1, Simon A Gayther10, Antonis C Antoniou4,5, Paul D P Pharoah4,5.
Abstract
To identify common alleles associated with different histotypes of epithelial ovarian cancer (EOC), we pooled data from multiple genome-wide genotyping projects totaling 25,509 EOC cases and 40,941 controls. We identified nine new susceptibility loci for different EOC histotypes: six for serous EOC histotypes (3q28, 4q32.3, 8q21.11, 10q24.33, 18q11.2 and 22q12.1), two for mucinous EOC (3q22.3 and 9q31.1) and one for endometrioid EOC (5q12.3). We then performed meta-analysis on the results for high-grade serous ovarian cancer with the results from analysis of 31,448 BRCA1 and BRCA2 mutation carriers, including 3,887 mutation carriers with EOC. This identified three additional susceptibility loci at 2q13, 8q24.1 and 12q24.31. Integrated analyses of genes and regulatory biofeatures at each locus predicted candidate susceptibility genes, including OBFC1, a new candidate susceptibility gene for low-grade and borderline serous EOC.Entities:
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Year: 2017 PMID： 28346442 PMCID： PMC5612337 DOI： 10.1038/ng.3826
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330