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Literature DB >> 27413101

At the Interface of Chemical and Biological Synthesis: An Expanded Genetic Code.

Abstract

The ability to site-specifically incorporate noncanonical amino acids (ncAAs) with novel structures into proteins in living cells affords a powerful tool to investigate and manipulate protein structure and function. More than 200 ncAAs with diverse biological, chemical, and physical properties have been genetically encoded in response to nonsense or frameshift codons in both prokaryotic and eukaryotic organisms with high fidelity and efficiency. In this review, recent advances in the technology and its application to problems in protein biochemistry, cellular biology, and medicine are highlighted.

Entities: Chemical

Mesh：

Substances：
Amino Acids
Proteins

Year: 2016 PMID： 27413101 PMCID： PMC5008073 DOI： 10.1101/cshperspect.a023945

Source DB: PubMed Journal: Cold Spring Harb Perspect Biol ISSN： 1943-0264 Impact factor: 10.005

123 in total

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Authors: J Christopher Anderson; Peter G Schultz
Journal: Biochemistry Date: 2003-08-19 Impact factor: 3.162

2. Interpretation of p-cyanophenylalanine fluorescence in proteins in terms of solvent exposure and contribution of side-chain quenchers: a combined fluorescence, IR and molecular dynamics study.

Authors: Humeyra Taskent-Sezgin; Juah Chung; Vadim Patsalo; Shigeki J Miyake-Stoner; Andrew M Miller; Scott H Brewer; Ryan A Mehl; David F Green; Daniel P Raleigh; Isaac Carrico
Journal: Biochemistry Date: 2009-09-29 Impact factor: 3.162

3. Exploring the potential impact of an expanded genetic code on protein function.

Authors: Han Xiao; Fariborz Nasertorabi; Sei-Hyun Choi; Gye Won Han; Sean A Reed; Raymond C Stevens; Peter G Schultz
Journal: Proc Natl Acad Sci U S A Date: 2015-05-18 Impact factor: 11.205

4. A fluorescent reporter of the phosphorylation status of the substrate protein STAT3.

Authors: Vanessa K Lacey; Angela R Parrish; Shuliang Han; Zhouxin Shen; Steven P Briggs; Yuguo Ma; Lei Wang
Journal: Angew Chem Int Ed Engl Date: 2011-07-29 Impact factor: 15.336

5. A convenient method for genetic incorporation of multiple noncanonical amino acids into one protein in Escherichia coli.

Authors: Ying Huang; William K Russell; Wei Wan; Pei-Jing Pai; David H Russell; Wenshe Liu
Journal: Mol Biosyst Date: 2010-02-15

6. A genetically encoded metabolically stable analogue of phosphotyrosine in Escherichia coli.

Authors: Jianming Xie; Lubica Supekova; Peter G Schultz
Journal: ACS Chem Biol Date: 2007-07-09 Impact factor: 5.100

7. Efficient synthesis and in vivo incorporation of acridon-2-ylalanine, a fluorescent amino acid for lifetime and Förster resonance energy transfer/luminescence resonance energy transfer studies.

Authors: Lee C Speight; Anand K Muthusamy; Jacob M Goldberg; John B Warner; Rebecca F Wissner; Taylor S Willi; Bradley F Woodman; Ryan A Mehl; E James Petersson
Journal: J Am Chem Soc Date: 2013-12-04 Impact factor: 15.419

8. RF1 knockout allows ribosomal incorporation of unnatural amino acids at multiple sites.

Authors: David B F Johnson; Jianfeng Xu; Zhouxin Shen; Jeffrey K Takimoto; Matthew D Schultz; Robert J Schmitz; Zheng Xiang; Joseph R Ecker; Steven P Briggs; Lei Wang
Journal: Nat Chem Biol Date: 2011-09-18 Impact factor: 15.040

Review 9. Unnatural amino acid incorporation in E. coli: current and future applications in the design of therapeutic proteins.

Authors: Kim Wals; Huib Ovaa
Journal: Front Chem Date: 2014-04-01 Impact factor: 5.221

10. Evolved orthogonal ribosomes enhance the efficiency of synthetic genetic code expansion.

Authors: Kaihang Wang; Heinz Neumann; Sew Y Peak-Chew; Jason W Chin
Journal: Nat Biotechnol Date: 2007-06-24 Impact factor: 54.908

42 in total

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2. Systematic Evaluation of Soluble Protein Expression Using a Fluorescent Unnatural Amino Acid Reveals No Reliable Predictors of Tolerability.

Authors: Zachary M Hostetler; John J Ferrie; Marc R Bornstein; Itthipol Sungwienwong; E James Petersson; Rahul M Kohli
Journal: ACS Chem Biol Date: 2018-09-20 Impact factor: 5.100

Review 3. General lack of structural characterization of chemically synthesized long peptides.

Authors: Jean A Boutin; André L Tartar; Alain van Dorsselaer; Hubert Vaudry
Journal: Protein Sci Date: 2019-03-25 Impact factor: 6.725

4. An in vitro tag-and-modify protein sample generation method for single-molecule fluorescence resonance energy transfer.

Authors: Kambiz M Hamadani; Jesse Howe; Madeleine K Jensen; Peng Wu; Jamie H D Cate; Susan Marqusee
Journal: J Biol Chem Date: 2017-07-28 Impact factor: 5.157